Multicentric Castleman's disease with abundant IgG4-positive cells: A clinical and pathological analysis of six cases

Journal of Clinical Pathology

Volumn 63, Issue 12, 2010, Pages 1084-1089

  Sato, Yasuharu ^a   Kojima, Masaru ^b   Takata, Katsuyoshi ^a   Morito, Toshiaki ^c   Mizobuchi, Kohichi ^c   Tanaka, Takehiro ^a   Inoue, Dai ^d   Shiomi, Hideyuki ^e   Iwao, Haruka ^f   Yoshino, Tadashi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c KAGAWA ROSAI HOSPITAL   (Japan)

^d KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; INTERLEUKIN 6; STEROID; TOCILIZUMAB;

ADULT; AGED; ANEMIA; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; DIFFERENTIAL DIAGNOSIS; EOSINOPHIL; FEMALE; GENE REARRANGEMENT; GERMINAL CENTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERGAMMAGLOBULINEMIA; HYPOALBUMINEMIA; HYPOCHOLESTEROLEMIA; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN HEAVY CHAIN GENE; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBOCYTOSIS;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; C-REACTIVE PROTEIN; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GIANT LYMPH NODE HYPERPLASIA; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-6; LYMPH NODES; LYMPHATIC DISEASES; MALE; MIDDLE AGED;

EID: 78649631982     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2010.082958     Document Type: Article

References (30)

1. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph-node hyperplasia resembling thymoma. Cancer 1956;9:822-30.
2. Flendrig JA, Schillings PHM. Benign giant lymphoma: the clinical signs and symptoms. Folia Med Neerl 1969;12:119-20.
3. Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972;29:670-83.
4. Frizzera G, Peterson BA, Bayrd ED, et al. A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol 1985;3:1202-16.
5. Nishimoto N, Kanakura Y, Aozasa K, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 2005;106:2627-32.
6. Kojima M, Nakamura S, Shimizu K, et al. Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. Int J Surg Pathol 2004;12:25-30.
7. Kojima M, Nakamura N, Tsukamoto N, et al. Clinical implications of idiopathic multicentric Castleman disease among Japanese: a report of 28 cases. Int J Surg Pathol 2008;16:391-8.
8. Sato Y, Kojima M, Takata K, et al. Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease. Mod Pathol 2009;22:589-99.
9. Cheuk W, Yuen HKL, Chu SYY, et al. Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol 2008;32:671-81.
10. Sato Y, Ichimura K, Tanaka T, et al. Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas. J Clin Pathol 2008;61:377-81.
11. Sato Y, Nakamura N, Nakamura S, et al. Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas. Mod Pathol 2006;19:1578-84.
12. Boulanger E, Fuentes V, Meignin V, et al. Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy. Ann Hematol 2006;85:833-40.
13. Kojima M, Miyawaki S, Takada S, et al. Lymphoplasmacytic infiltrate of regional lymph nodes in Küttner's tumor (chronic sclerosing sialadenitis). A report of 3 cases. Int J Surg Pathol 2008;16:263-8.
14. Frizzera G, Massarelli G, Banks PM, et al. A systemic lymphoproliferative disorder with morphologic features of Castleman's disease. Pathological findings in 15 patients. Am J Surg Pathol 1983;7:211-31.
15. Ye B, Gao SG, Li W, et al. A retrospective study of unicentric and multicentric Castleman's disease: a report of 52 patients. Med Oncol Published Online First: 24 November 2009. doi:10.1007/s12032-009-9355-0.
16. Sato Y, Notohara K, Kojima M, et al. IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 2010;60:247-58.
17. Yoshizaki K, Matsuda T, Nishimoto N, et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 1989;74:1360-7.
18. Kurosawa S, Akiyama N, Ohwada A, et al. Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. Jpn J Clin Oncol 2009;39:682-5.
19. Masaki Y, Dong L, Kurose N, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis 2009;68:1310-15.
20. McGhee JR, Beagley KW, Eldridge JH, et al. Interleukin cascade for the regulation of IgA synthesis and immune responses. Protides Biol Fluids 1989;36:183-91.
21. Jabara HH, Ahern DJ, Vercelli D, et al. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J Immunol 1991;147:1557-60.
22. Jenmalm MC, Björkstén B, Macaubas C, et al. Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses. Pediatr Allergy Immunol 1999;10:168-77.
23. Kawano Y, Noma T, Kou K, et al. Regulation of human IgG subclass production by cytokines: human IgG subclass production enhanced differentially by interleukin-6. Immunology 1995;84:278-84.
24. Bertolini JN, Benson EM. The role of human interleukin-6 in B-cell isotype regulation and differentiation. Cell Immunol 1990;125:197-209.
25. Ishida F, Kitano K, Kobayashi H, et al. Elevated IgG4 levels in a case with multicentric Castleman's disease. Br J Haematol 1997;99:981-2.
26. Zen Y, Fujii T, Sato Y, et al. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease. Mod Pathol 2007;20:884-94.
27. Zen Y, Fujii T, Harada K, et al. Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology 2007;45:1538-46.
28. Kamisawa T, Chen PY, Tu Y, et al. Pancreatic cancer with a high serum IgG4 concentration. World J Gastroenterol 2006;12:6225-8.
29. Ghazale A, Chari ST, Smyrk TC, et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterol 2007;102:1646-53.
30. Kuo TT, Chen TC, Lee LY, et al. IgG4-positive plasma cells in cutaneous Rosai-Dorfman disease: an additional immunohistochemical feature and possible relationship to IgG4-related sclerosing disease. J Cutan Pathol 2009;36:1069-73.