Plasma zinc concentration responds rapidly to the initiation and discontinuation of short-term zinc supplementation in healthy men

Journal of Nutrition

Volumn 140, Issue 12, 2010, Pages 2128-2133

  Wessells, K Ryan ^a   Jorgensen, Joshua M ^a   Hess, Sonja Y ^a   Woodhouse, Leslie R ^b   Peerson, Janet M ^a   Brown, Kenneth H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; PLACEBO; ZINC; ZINC SULFATE;

ACCURACY; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; HEMOGLOBIN BLOOD LEVEL; HUMAN; LABORATORY TEST; MALE; NORMAL HUMAN; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; ZINC BLOOD LEVEL;

ADULT; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; HUMANS; MALE; MIDDLE AGED; PLACEBOS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; ZINC;

EID: 78649574432     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.122812     Document Type: Article

References (14)

1. Hess SY, Peerson JM, King JC, Brown KH. Use of serum zinc concentration as an indicator of population zinc status. Food Nutr Bull. 2007;28:S403-29.
2. Lowe NM, Woodhouse LR, Sutherland B, Shames DM, Burri BJ, Abrams SA, Turnlund JR, Jackson MJ, King JC. Kinetic parameters and plasma zinc concentration correlate well with net loss and gain of zinc from men. J Nutr. 2004;134:2178-81. (Pubitemid 39201582)
3. Brown KH, Rivera JA, Bhutta Z, Gibson RS, King JC, Lonnerdal B, Ruel MT, Sandtrom B, Wasantwisut E, et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull. 2004;25:S99-203.
4. Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutritional Examination Survey Data (1976-1980). Am J Clin Nutr. 2003;78:756-64.
5. Lowe NM, Fekete K, Decsi T. Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr. 2009;89:S2040-51.
6. International Zinc Nutrition Consultative Group. Assessing population zinc status with serum zinc concentration. IZiNCG technical brief no 2. Davis (CA): University of California; 2007 [cited 2010 31 Aug]. Available at: http://www.izincg.org.
7. Sullivan VK, Burnett FR, Cousins RJ. Metallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation. J Nutr. 1998;128:707-13.
8. Sullivan VK, Cousins RJ. Competitive reverse transcriptase-polymerase chain reaction shows that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels. J Nutr. 1997; 127:694-8.
9. Cao J, Cousins RJ. Metallothionein mRNA in monocytes and peripheral blood mononuclear cells and in cells from dried blood spots increases after zinc supplementation of men. J Nutr. 2000; 130:2180-7.
10. Feillet-Coudray C, Meunier N, Rambeau M, Brandolini-Bunlon M, Tressol JC, Andriollo M, Mazur A, Cashman KD, Coudray C. Longterm moderate zinc supplementation increases exchangeable zinc pool masses in late-middle-aged men: the Zenith Study. Am J Clin Nutr. 2005;82:103-10.
11. Food and Nutrition Board IOM. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press; 2001.
12. USDA Agricultural Research Service. Continuing Survey of Food Intakes by Individuals. 1994-96. Springfield (VA): National Technical Information Service CD-Rom; 2002.
13. Tran CD, Miller LV, Krebs NF, Lei S, Hambidge KM. Zinc absorption as a function of the dose of zinc sulfate in aqueous solution. Am J Clin Nutr. 2004;80:1570-3. (Pubitemid 41103855)
14. Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, Khatun F, Martorell R, Ninh NX, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. J Pediatr. 1999;135:689-97.