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Volumn , Issue , 2010, Pages

Experimental determination of the key heat transfer mechanisms in pharmaceutical freeze drying

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SUBSTANCE; DRYING CONDITION; DRYING CYCLE; EXPERIMENTAL DETERMINATION; FREEZE DRYING; GAS CONDUCTION; HEAT TRANSFER MECHANISM; HEAT TRANSFER RATE; LABORATORY SCALE; LOW-PRESSURE CONDITIONS; PURE WATER; SEPARATION DISTANCES; SUBLIMATION RATES; TRANSFER MODES;

EID: 78649554084     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper
Times cited : (2)

References (15)
  • 1
    • 0019062163 scopus 로고
    • The effect of chamber pressure on heat transfer in the freeze drying of parenteral solutions
    • S.L. Nail. The effect of chamber pressure on heat transfer in the freeze drying of parenteral solutions. J. Parenteral Drug Assoc., 34, 1980, pp:358-368
    • (1980) J. Parenteral Drug Assoc. , vol.34 , pp. 358-368
    • Nail, S.L.1
  • 2
    • 0020596449 scopus 로고
    • Physical chemistry of freeze-drying: Measurement of sublimation rates for frozen aqueous solutions by a microbalance technique
    • Pikal MJ, Shah S, Senior D, and Lang JE. Physical chemistry of freeze-drying: measurement of sublimation rates for frozen aqueous solutions by a microbalance technique. J. Pharm. Sci., 72, 1983, pp:635-50
    • (1983) J. Pharm. Sci. , vol.72 , pp. 635-650
    • Pikal, M.J.1    Shah, S.2    Senior, D.3    Lang, J.E.4
  • 3
    • 0021198926 scopus 로고
    • Mass and heat transfer in vial freeze-drying of pharmaceuticals: Role of the vial
    • M. J. Pikal, M.L. Roy, and S. Shah. Mass and heat transfer in vial freeze-drying of pharmaceuticals: Role of the vial. J. Pharm. Sci., 73, 1984, pp 1224-1237
    • (1984) J. Pharm. Sci. , vol.73 , pp. 1224-1237
    • Pikal, M.J.1    Roy, M.L.2    Shah, S.3
  • 4
    • 0021836493 scopus 로고
    • Use of laboratory data in freeze drying process design: Heat and mass transfer coefficients and the computer simulation of freeze drying
    • M.J. Pikal. Use of laboratory data in freeze drying process design: Heat and mass transfer coefficients and the computer simulation of freeze drying. J. Parenter. Sci. Technol., 39, 1985, pp 115136
    • (1985) J. Parenter. Sci. Technol. , vol.39 , pp. 115136
    • Pikal, M.J.1
  • 5
    • 33746052920 scopus 로고    scopus 로고
    • Heat and mass transfer scale-up issues during freeze-drying, III: Control and characterization of dryer differences via operational qualification tests
    • S. Rambhatla, S. Tchessalov, and Michael J. Pikal, Heat and Mass Transfer Scale-Up Issues During Freeze-Drying, III: Control and Characterization of Dryer Differences via Operational Qualification Tests, AAPS PharmSciTech, Vol. 7, No. 2, 2006
    • (2006) AAPS Pharm Sci Tech. , vol.7 , Issue.2
    • Rambhatla, S.1    Tchessalov, S.2    Pikal, M.J.3
  • 6
    • 35648934050 scopus 로고    scopus 로고
    • Determination of shelf heat transfer coefficients along the shelf flow path of a freeze dryer using the shelf fluid temperature perturbation approach
    • Wei Y. Kuu a; Steven L. Nail a;Lisa M. Hardwick, Determination of Shelf Heat Transfer Coefficients Along the Shelf Flow Path of a Freeze Dryer Using the Shelf Fluid Temperature Perturbation Approach, Pharmaceutical Development and Technology, Vol. 12, Issue 5, 2007 pp. 485 - 494
    • (2007) Pharmaceutical Development and Technology , vol.12 , Issue.5 , pp. 485-494
    • Kuu, W.Y.1    Nail, S.L.2    Hardwick, L.M.3
  • 8
    • 77957332975 scopus 로고    scopus 로고
    • The effect of dryer load on freeze drying process design
    • Published Online: 10 May
    • Patel M. Patel, Feroz Jameel and Michael J. Pikal, The effect of dryer load on freeze drying process design, J. Pharm. Sci., Published Online: 10 May 2010
    • (2010) J. Pharm. Sci.
    • Patel, P.M.1    Jameel, F.2    Pikal, M.J.3
  • 9
    • 14644437110 scopus 로고    scopus 로고
    • The nonsteady state modeling of freeze drying: In-process product temperature and moisture content mapping and pharmaceutical product quality applications
    • Pikal MJ, Cardon S, Bhugra C, Jameel F, Rambhatla S, Mascarenhas WJ, Akay HU, The nonsteady state modeling of freeze drying: in-process product temperature and moisture content mapping and pharmaceutical product quality applications, Pharm Dev Technol. 10(1), 2005, pp. 17-32
    • (2005) Pharm Dev Technol. , vol.10 , Issue.1 , pp. 17-32
    • Pikal, M.J.1    Cardon, S.2    Bhugra, C.3    Jameel, F.4    Rambhatla, S.5    Mascarenhas, W.J.6    Akay, H.U.7
  • 10
    • 0032553851 scopus 로고    scopus 로고
    • Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies
    • P. Sheehan, A. I. Liapis, Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies, Biotechnology and Bioengineering, Vol. 60 Issue 6, 1998, pp. 712 - 728
    • (1998) Biotechnology and Bioengineering , vol.60 , Issue.6 , pp. 712-728
    • Sheehan, P.1    Liapis, A.I.2
  • 11
    • 0141764849 scopus 로고    scopus 로고
    • Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect
    • article 14
    • Shailaja Rambhatla and Michael J. Pikal. Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect. AAPS PharmSciTech., 4(2): article 14, 2003
    • (2003) AAPS Pharm Sci Tech. , vol.4 , Issue.2
    • Rambhatla, S.1    Pikal, M.J.2
  • 12
    • 68949142801 scopus 로고    scopus 로고
    • Computational analysis of fluid dynamics in pharmaceutical freeze-drying
    • September
    • A. Alexeenko, A. Ganguly, S. Nail, Computational Analysis of Fluid Dynamics in Pharmaceutical Freeze-Drying, Journal of Pharmaceutical Sciences, Vol. 98 (9), September 2009, pp. 3483-3494
    • (2009) Journal of Pharmaceutical Sciences , vol.98 , Issue.9 , pp. 3483-3494
    • Alexeenko, A.1    Ganguly, A.2    Nail, S.3
  • 15
    • 0037057321 scopus 로고    scopus 로고
    • Heat transfer in vial lyophilization
    • Brulls M and Rasmuson A. Heat transfer in vial lyophilization. Int. J. Pharm., 246:1-16, 2002
    • (2002) Int. J. Pharm. , vol.246 , pp. 1-16
    • Brulls, M.1    Rasmuson, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.