Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies

Biotechnology and Bioengineering

Volumn 60, Issue 6, 1998, Pages 712-728

  Sheehan, P ^a   Liapis, A I ^a  

^a Architectural and Environmental Engineering   (United States)

Author keywords

Distribution of bound water; Freeze drying in vials; Lyophilization in vials; Surface geometry of moving interface; Velocity of moving interface

Indexed keywords

DRYING; INTERFACES (MATERIALS); MATHEMATICAL MODELS; MELTING; MOLECULAR DYNAMICS; NUMERICAL METHODS; TEMPERATURE; WATER;

FREEZE DRYING; LYOPHILIZATION; OPERATIONAL POLICIES; VIALS;

DRUG PRODUCTS;

BIOLOGICAL PRODUCT; DRUG; WATER;

ARTICLE; DYNAMICS; FREEZE DRYING; HEAT; MATHEMATICAL MODEL; QUALITY CONTROL; SURFACE PROPERTY; TEMPERATURE;

EID: 0032553851     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19981220)60:6<712::AID-BIT8>3.0.CO;2-4     Document Type: Article

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