Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

International Journal of Experimental Pathology

Volumn 91, Issue 6, 2010, Pages 537-545

  Fávaro, Wagner J ^a,b   Cagnon, Valéria H A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Diabetes mellitus; Endostatin; IGFR 1; Insulin; Steroid hormones; VEGF; Ventral prostate

Indexed keywords

ANDROGEN RECEPTOR; DEPOSTERON; ENDOSTATIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOSE; ISOPHANE INSULIN; SOMATOMEDIN C RECEPTOR; STEROID RECEPTOR; TESTOSTERONE; TESTOSTERONE CIPIONATE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOCRINE DISEASE; ESTROGEN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONAL THERAPY; HORMONE RESPONSE; INSULIN SENSITIVITY; INSULIN TREATMENT; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TESTOSTERONE BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; ESTRADIOL; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; MICE; MICE, INBRED NOD; PROSTATE; RECEPTOR, IGF TYPE 1; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 78649519863     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2010.00739.x     Document Type: Article

References (61)

1. Abdollahi A., Lipson K.E., Sckell A. et al. (2003) Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects. Cancer Res. 63, 8890-8898.
2. Aiello L.P. & Wong J.S. (2000) Role of vascular endothelial growth factor in diabetic vascular complications. Kidney Int. Suppl. 77, 113-119.
3. Anderson L.C. (1983) Effects of alloxan diabetes and insulin in vivo on rat parotid gland. Am. J. Physiol. 245, 431-437.
4. Arcolino F.O., Ribeiro D.L., Gobbo M.G., Taboga S.R., Góes R.M. (2009) Proliferation and apoptotic rates and increased frequency of p63-positive cells in the prostate acinar epithelium of alloxan-induced diabetic rats. Int. J. Exp. Pathol. 91, 144-154.
5. Asai K., Kanazawa H., Otani K., Shiraishi S., Hirata K., Yoshikawa J. (2002) Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects. J. Allergy Clin. Immunol. 110, 571-575.
6. Ballester J., Munoz M.C., Dominguez J., Rigau T., Guinovart J.J., Rodriguez-Gil J.E. (2004) Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms. J. Androl. 25, 706-719.
7. Beeson P.B. (1994) Age and sex associations of 40 autoimmune diseases. Am. J. Med. 96, 457-462.
8. Bynoe M.S., Grimaldi C.M., Diamond B. (2000) Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells. Proc. Natl. Acad. Sci. USA 97, 2703-2708.
9. Chan Q.K., Lam H.M., Ng C.F. et al. (2010) Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ. [Epub ahead of print] doi:10.1038/cdd.2010.20.
10. Ciardullo A.V., Daghio M.M., Brunnetti M. et al. (2004) Audit of a shared-care program for persons with diabetes: baseline and 3 annual follow-ups. Acta Diabetol. 41, 9-13.
11. Cunha G.R., Hayward S.W., Wang Y.Z. (2002) Role of stroma in carcinogenesis of the prostate. Differentiation 70, 473-485.
12. Daubrese J.C., Meunier J., Wilmotte A.S., Luyckx A.S., Lefebvre P.J. (1978) Pituitary-testicular axis in diabetic men with and without impotence sexual. Diabete Metab. 4, 233-237.
13. Denley A., Cosgrove L.J., Booker G.W., Wallace J.C., Forbes B.E. (2005) Molecular interactions of the IGF system. Cytokine Growth Factor Rev. 16, 421-439.
14. Desai K.V. & Kondaiah P. (2000) Androgen ablation results in differential regulation of transforming growth factor-β isoforms in rat male accessory sex organs and epididymis. J. Mol. Endocrinol. 24, 253-260.
15. Djavan B., Waldert M., Seitz C., Marberger M. (2001) Insulin-like growth factors and prostate cancer. World J. Urol. 19, 225-233.
16. Duh E. & Aiello L.P. (1999) Vascular endothelial growth factor and diabetes. The agonist versus antagonist paradox. Diabetes 48, 1899-1906.
17. Fávaro W.J., Padovani C.R., Cagnon V.H. (2009) Ultrastructural and proliferative features of the ventral lobe of the prostate in non-obese diabetic mice (NOD) following androgen and estrogen replacement associated to insulin therapy. Tissue Cell 41, 119-132.
18. Franck-Lissbrant I., Häggström S., Damber J.E. (1998) Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology 139, 451-456.
19. Gnanapragasam V.J., Robson C.N., Leung H.Y., Neal D.E. (2000) Androgen receptor signalling in the prostate. BJU Int. 86, 1001-1013.
20. He Z., Opland D.M., Way K.J. (2006) Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler. Thromb. Vasc. Biol. 26, 787-793.
21. Ikeda K., Wada Y., Foster H.E. Jr, Wang Z., Weiss R.M., Latifpour J. (2000) Experimental diabetes-induced regression of the rat prostate is associated with an increased expression of transforming growth factor-β. J. Urol. 164, 180-185.
22. Ilic M., Vlajinac H., Marinkovic J. (1996) Case-control study of risk factors for prostate cancer. Br. J. Cancer 74, 1682-1686.
23. Isayeva T., Moore L.D., Chanda D., Chen D., Ponnazhagan S. (2009) Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status. Prostate 69, 1055-1066.
24. Izzedine H., Bahleda R., Khayat D. (2009) Electrolyte disorders related to EGFR-targeting drugs. Crit. Rev. Oncol. Hematol. 73, 213-219.
25. Kamath A., Helie M., Bifulco C.B., Li W.W., Concato J., Jain D. (2009) Lack of immunohistochemical detection of VEGF in prostate carcinoma. Appl. Immunohistochem. Mol. Morphol. 17, 227-232.
26. Kasper J.S., Liu Y., Pollak M.N., Rifai N., Giovannucci E. (2008) Hormonal profile of diabetic men and the potential link to prostate cancer. Cancer Causes Control 19, 703-710.
27. Lazari M.F., Lucas T.F., Yasuhara F. et al. (2009) Estrogen receptors and function in the male reproductive system. Arq. Bras. Endocrinol. Metabol. 53, 923-933.
28. Marker P.C., Donjacour A.A., Dahiya R., Cunha G.R. (2003) Hormonal cellular and molecular control of cprostatic development. Dev. Biol. 253, 165-174.
29. Markopoulos A.K., Poulopoulos A.K., Kavavis I., Papanayotou P. (2000) Immunohistochemical detection on insulin-like growth factor I in the labial salivary glands of patients with Sjogren's syndrome. Oral Dis. 6, 31-34.
30. McGinn S., Saad S., Poronnik P., Pollock C.A. (2003) High glu-cose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. Am. J. Physiol. Endocrinol. Metab. 285, 708-717.
31. Mcpherson S.J., Ellen S.J., Simpson E.R., Patchev V., Fritzemeier K.H., Risbridger G.P. (2007) Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. Endocrinology 148, 566-574.
32. Van Moorselaar R.J. & Voest E.E. (2002) Angiogenesis in prostate cancer: its role in disease progression and possible therapeutic approaches. Mol. Cell. Endocrinol. 197, 239-250.
33. Nakagawa T. (2007) Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Am. J. Physiol. Renal Physiol. 292, 1665-1672.
34. Naslund M.J., Strandberg J.D., Coffey D.S. (1988) The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J. Urol. 140, 1049-1053.
35. Nishi N., Oya H., Matsumoto K., Nakamura T., Miyanaka H., Wada F. (1996) Changes in gene expression of growth factors and their receptors during castration-induced involution and androgen-induced regrowth of rat prostates. Prostate 28, 139-152.
36. Ohlson N., Bergh A., Stattin P., Wikström P. (2007) Castration-induced epithelial cell death in human prostate tissue is related to locally reduced IGF-1 levels. Prostate 67, 32-40.
37. Ohta T., Matsui K., Miyajima K. et al. (2007) Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats. Exp. Anim. 56, 355-362.
38. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S. (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumour growth. Cell 88, 277-285.
39. Osterby R., Bangstad H.J., Nyberg G., Rudberg S. (2001) On glomerular structural alterations in type-1 diabetes. Companions of early diabetic glomerulopathy. Virchows Arch. 438, 129-135.
40. Pandini G., Mineo R., Frasca F. et al. (2005) Androgens up-regulate the insulin-like growth factor-1 receptor in prostate cancer cells. Cancer Res. 65, 1849-1857.
41. Peyromaure M., Badoual C., Camparo P. et al. (2007) Plasma levels and expression of vascular endothelial growth factor-A in human localized prostate cancer. Oncol. Rep. 18, 145-149.
42. Prabhu A., Xu Q., Manigrasso M.B. et al. (2010) Expression of aromatase, androgen and estrogen receptors in peripheral target tissues in diabetes. Steroids 75, 779-787.
43. Prins G.S., Birch L., Couse J.F., Choi I., Katzenellenbogen B., Korach K.S. (2001) Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice. Cancer Res. 61, 6089-6097.
44. Ribeiro D.L., Caldeira E.J., Candido E.M., Manzato A.J., Taboga S.R., Cagnon V.H. (2006) Prostatic stromal microenvironment and experimental diabetes. Eur. J. Histochem. 50, 51-60.
45. Ribeiro D.L., Marques S.F., Alberti S. et al. (2008) Malignant lesions in the ventral prostate of alloxan-induced diabetic rats. Int. J. Exp. Pathol. 89, 276-283.
46. Risbridger G.P., Wang H., Young P. et al. (2001) Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Dev. Biol. 231, 432-442.
47. Risbridger G.P., Bianco J.J., Ellem S.J., Mcpherson S.J. (2003) Oestrogens and prostate cancer. Endocr. Relat. Cancer 10, 187-191.
48. Saito M., Nishi K., Foster-Junior H.E., Weiss R.M., Latifpour J. (1996) Effect of experimental diabetes on rat prostateendothelin receptors. Eur. J. Pharm. 310, 197-200.
49. Schmidt A., Sommer F., Ozgür E. et al. (2004) Vessels in benign prostatic hyperplasia contain more binding sites for endostatin than vessels in normal prostate tissue. Eur. Urol. 46, 765-767.
50. Shirai H., Sato T., Hara T., Minagi S. (1998) The effect of diabetes mellitus on histopathological changes in the tissues under denture base and without mechanical pressure. J. Oral Rehabil. 5, 715-720.
51. Soulitzis N., Karyotis I., Delakas D., Spandidos D.A. (2006) Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. Int. J. Oncol. 29, 305-314.
52. Tesone M., Valle L.B.S., Foglia V.G., Charreau E.H. (1976) Endocrine function of the testis in streptozotocin diabetic rats. Acta Physiol. Lat. Am. 26, 387-394.
53. Tesone M., Oliveira-Filho R.M., Valle L.B. et al. (1980) Androgen receptors in the diabetic rat. Diabetologia 18, 385-390.
54. Toorians A.W., Kelleher S., Gooren L.J., Jimenez M., Handelsman D.J. (2003) Estimating the contribution of the prostate to blood dihydrotestosterone. J. Clin. Endocrinol. Metab. 88, 5207-5211.
55. Waltenberger J. (2009) VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus. Biochem. Soc. Trans. 37, 1167-1170.
56. Wang Z.J., Ikeda K., Foster-Junior H.E., Weiss R.M., Latifpour J. (2000) Expression and localization of basic fibroblast growth factor in diabetic rat prostate. BJU Int. 85, 945-952.
57. Will J.C., Vinicor F., Calle E.E. (1999) Is diabetes mellitus associated with prostate incidence and survival? Epidemiology 10, 313-318.
58. Wu W.M., Lin B.F., Su Y.C., Suen J.L., Chiang B.L. (2000) Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand. J. Immunol. 52, 393-400.
59. Yono M., Mane S.M., Lin A., Weiss R.M., Latifpour J. (2008) Differential effects of diabetes induced by streptozotocin and that develops spontaneously on prostate growth in Bio Breeding (BB) rats. Life Sci. 83, 192-197.
60. Zhang Z., Duan L., Du X., Ma H., Park I., Lee C. (2008) The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK. Prostate 68, 508-516.
61. Zhu M., Bi X., Jia Q., Shangguan S. (2009) The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor. Biomed. Pharmacother. 64, 208-213.