The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans

Nephrology Dialysis Transplantation

Volumn 25, Issue 12, 2010, Pages 4093-4096

  Cherney, David Z I ^a   Lai, Vesta ^a   Miller, Judith A ^a   Scholey, James W ^a   Reich, Heather N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

aldosterone escape; angiotensin II type 2 receptor gene polymorphism; renal haemodynamic function; renin angiotensin aldosterone system

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; IRBESARTAN; NORADRENALIN;

ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPOTENSION; MALE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; VASODILATATION;

ADULT; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; FEMALE; HEMODYNAMICS; HUMANS; KIDNEY; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN; RENIN-ANGIOTENSIN SYSTEM; TETRAZOLES; TIME FACTORS;

EID: 78649515837     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq564     Document Type: Article

References (17)

1. Booz GW. Cardiac angiotensin AT2 receptor: what exactly does it do? Hypertension 2004; 43: 1162-1163
2. Naruse M, Tanabe A, Sato A et al. Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats. Hypertension 2002; 40: 28-33
3. Mazzocchi G, Gottardo G, Macchi Vet al. The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats. Endocr Res 1998; 24: 17-28
4. Belloni AS, Andreis PG, Macchi Vet al. Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland. Endocr Res 1998; 24: 1-15
5. Warnecke C, Mugrauer P, Surder D et al. Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1729-R1735
6. Alfakih K, Lawrance RA, Maqbool A et al. The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease. Eur Heart J 2005; 26: 584-589
7. Herrmann SM, Nicaud V, Schmidt-Petersen K et al. Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies. Eur J Heart Fail 2002; 4: 707-712
8. Nishimura H, Yerkes E, Hohenfellner K et al. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell 1999; 3: 1-10
9. Schmieder RE, Erdmann J, Delles C et al. Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J Am Coll Cardiol 2001; 37: 175-182
10. Erdmann J, Guse M, Kallisch H et al. Novel intronic polymorphism (+1675G/A) in the human angiotensin II subtype 2 receptor gene. Hum Mutat 2000; 15: 487
11. Alfakih K, Maqbool A, SiVananthan M et al. Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. Hypertension 2004; 43: 1189-1194
12. Delles C, Erdmann J, Jacobi J et al. Lack of association between polymorphisms of angiotensin II receptor genes and response to short-term angiotensin II infusion. J Hypertens 2000; 18: 1573-1578
13. Miller JA, Curtis JR, Sochett EB. Relationship between diurnal blood pressure, renal hemodynamic function, and the renin-angiotensin system in type 1 diabetes. Diabetes 2003; 52: 1806-1811
14. Schnurr E, Lahme W, Kuppers H. Measurement of renal clearance of inulin and PAH in the steady state without urine collection. Clin Nephrol 1980; 13: 26-29
15. Cherney DZ, Lai V, Scholey JW. Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study. Diab Care 2010; 33: 361-365
16. Cherney DZ, Miller JA, ScholeyJWet al. The effectof cyclooxygenase-2 inhibition on renal hemodynamic function in humans with type 1 diabetes. Diabetes 2008; 57: 688-695
17. Sochett EB, Cherney DZ, Curtis JR et al. Impact of renin angiotensin system modulation on the hyperfiltration state in type 1 diabetes. J Am Soc Nephrol 2006; 17: 1703-1709