A Dynamical Model for the Control of the Gonadotrophin-Releasing Hormone Neurosecretory System

Journal of Neuroendocrinology

Volumn 22, Issue 12, 2010, Pages 1251-1266

  Vidal, A ^a   Clement F ^b  

^a UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^b INRIA ROCQUENCOURT   (France)

Author keywords

GnRH; Hormone time series; Mathematical model; Neuroendocrine systems; Reproductive axis

Indexed keywords

ESTRADIOL; GONADORELIN; PROGESTERONE;

ARTICLE; BRAIN NERVE CELL; DYNAMICS; EXCITATION; GONADORELIN RELEASE; LUTEAL PHASE; NEUROSECRETION; NONHUMAN; OVARY CYCLE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; MODELS, BIOLOGICAL; NEUROSECRETORY SYSTEMS;

EID: 78649514484     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2010.02055.x     Document Type: Article

References (36)

1. Herbison AE. Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr Rev 1998; 19: 302-330.
2. Clarkson J, Herbison AE. Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. J Neuroendocrinol 2008; 21: 305-311.
3. Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocr Rev 2009; 30: 713-743.
4. Evans NP, Richter TA, Skinner DC, Robinson JE. Neuroendocrine mechanisms underlying the effects of progesterone on the oestradiol-induced GnRH/LH surge. Reprod Suppl 2002; 59: 57-66.
5. Xia L, Van Vugt D, Alston EJ, Luckhaus J, Ferin M. A surge of gonadotropin-releasing hormone accompanies the estradiol-induced gonadotropin surge in the rhesus monkey. Endocrinology 1992; 131: 2812-2820.
6. Clément F, Françoise J-P. Mathematical modeling of the GnRH-pulse and surge generator. SIAM J Appl Dyn Syst 2007; 6: 441-456.
7. Clément F, Vidal A. Foliation-based parameter tuning in a model of the GnRH pulse and surge generator. SIAM J Appl Dyn Syst 2009; 8: 1591-1631.
8. Moenter SM, Caraty A, Locatelli A, Karsch FJ. Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge. Endocrinology 1991; 129: 1175-1182.
9. Moenter SM, Caraty A, Karsch FJ. The estradiol-induced surge of gonadotropin-releasing hormone in the ewe. Endocrinology 1990; 127: 1375-1384.
10. Evans NP, Dahl GE, Padmanabhan V, Thrun LA, Karsch FJ. Estradiol requirements for induction and maintenance of the gonadotropin-releasing hormone surge: implications for neuroendocrine processing of the estradiol signal. Endocrinology 1997; 138: 5408-5414.
11. Baird DT, Swanston IA, McNeilly AS. Relationship between LH, FSH, and prolactin concentration and the secretion of androgens and estrogens by the preovulatory follicle in the ewe. Biol Reprod 1981; 24: 1013-1025.
12. Baird DT, McNeilly AS. Gonadotrophic control of follicular development and function during the oestrous cycle of the ewe. J Reprod Fertil Suppl 1981; 30: 119-133.
13. Terasawa EI, Keen KL, Modi K, Claudew P. Pulsatile release of luteinizing hormone-releasing hormone (LHRH) in cultured LHRH neurons derived from the embryonic olfactory placode of the rhesus monkey. Endocrinology 1999; 140: 1432-1441.
14. Terasawa EI, Schanhofer WK, Keen KL, Luchansky L. Intracellular Ca(2+) oscillations in luteinizing hormone-releasing hormone neurons derived from the embryonic olfactory placode of the rhesus monkey. J Neurosci 1999; 19: 5898-5909.
15. Evans NP, Dahl GE, Mauger DT, Karsch FJ. Estradiol induces both qualitative and quantitative changes in the pattern of gonadotropin-releasing hormone secretion during the presurge period in the ewe. Endocrinology 1995; 136: 1603-1609.
16. Moenter SM, Brand RC, Karsch FJ. Dynamics of gonadotropin-releasing hormone (GnRH) secretion during the GnRH surge: insights into the mechanism of GnRH surge induction. Endocrinology 1992; 130: 2978-2984.
17. Skinner DC, Caraty A, Malpaux B, Evans NP. Simultaneous measurement of gonadotropin-releasing hormone in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe. Endocrinology 1997; 138: 4699-4704.
18. Caraty A, Skinner DC. Progesterone priming is essential for the full expression of the positive feedback effect of estradiol in inducing the preovulatory gonadotropin-releasing hormone surge in the ewe. Endocrinology 1999; 140: 165-170.
19. Kasa-Vubu JZ, Dahl GE, Evans NP, Thrun LA, Moenter SM, Padmanabhan V, Karsch FJ. Progesterone blocks the estradiol-induced gonadotropin discharge in the ewe by inhibiting the surge of gonadotropin-releasing hormone. Endocrinology 1992; 131: 208-212.
20. Harris TG, Dye S, Robinson JE, Skinner DC, Evans NP. Progesterone can block transmission of the estradiol-induced signal for luteinizing hormone surge generation during a specific period of time immediatly after activation of the gonadotropin-releasing hormone surge-generating system. Endocrinology 1999; 140: 827-834.
21. Richter TA, Spackman DS, Robinson JE, Dye S, Harris TG, Skinner DC, Evans NP. Role of endogenous opioid peptides in mediating progesterone-induced disruption of the activation and transmission stages of the GnRH surge induction process. Endocrinology 2001; 142: 5212-5219.
22. Richter TA, Robinson JE, Dye S, Evans NP. Progesterone blocks the estradiol-stimulated luteinizing hormone surge by disrupting activation in response to a stimulatory estradiol signal in the ewe. Endocrinology 2002; 67: 119-125.
23. Goodman RL, Gibson M, Skinner DC, Lehman MN. Neuroendocrine control of pulsatile GnRH/LH secretion during the ovarian cycle: evidence from the ewe. Reprod Suppl 2002; 59: 41-56.
24. Evans NP, Dahl GE, Glover BH, Karsch FJ. Central regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe. Endocrinology 1994; 134: 1806-1811.
25. Skinner DC, Evans NP, Delaleu B, Goodman RL, Bouchard P, Caraty A. The negative feedback actions of progesterone on gonadotropin releasing hormone secretion are transduced by the classical progesterone receptor. PNAS 1998; 95: 10978-10983.
26. Robinson JE, Forsdike RA, Taylor JA. In utero exposure of female lambs to testosterone reduces the sensitivity of the GnRH neuronal network to inhibition by progesterone. Endocrinology 1999; 140: 5797-5805.
27. Smith T. Sex steroid control of hypothalamic Kiss1 expression in sheep and rodents: comparative aspects. Peptides 2008; 30: 94-102.
28. Goodman RL, Lehman MN, Smith JT, Coolen LM, De Oliveira CVR, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology 2007; 148: 5752-5760.
29. Ciccone NA, Kaiser UB. The biology of gonadotroph regulation. Curr Opin Endocrinol Diabetes Obes 2009; 16: 321-327.
30. Bertram R, Li YX. A mathematical model for the actions of activin, inhibin, and follistatin on pituitary gonadotrophs. Bull Math Biol 2008; 70: 2211-2228.
31. Lim S, Pnueli L, Tan JH, Naor Z, Rajagopal G, Melamed P. Negative feedback governs gonadotrope frequency-decoding of gonadotropin releasing hormone pulse-frequency. PLoS ONE 2009; 29: e7244.
32. 2+/NFAT signaling pathway decode GnRH pulse frequency? J Biol Chem 2009; 284: 35746-35757.
33. Echenim N, Monniaux D, Sorine M, Clément F. Multi-scale modeling of the follicle selection process in the ovary. Math Biosci 2005; 198: 57-79.
34. Echenim N, Clément F, Sorine M. Multi-scale modeling of follicular ovulation as a reachability problem. Multiscale Model Simul 2007; 6: 895-912.
35. Clément F. Multiscale modelling of endocrine systems: new insight on the gonadotrope axis. ESAIM Proceedings 2009; 27: 209-226.
36. Clément F. Optimal control of the cell dynamics in the granulosa of ovulatory follicles. Math Biosci 1998; 152: 123-142.