Different mechanisms for heterogeneity in leprosy susceptibility can explain disease clustering within households

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Fischer, Egil ^a,b   Vlas, De Sake ^a   Meima, Abraham ^a,c   Habbema, Dik ^a   Richardus, Jan ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c Public Health Service of the Rotterdam Region   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; DAPSONE;

ARTICLE; BACTERIAL TRANSMISSION; BANGLADESH; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENETIC SUSCEPTIBILITY; HEREDITY; HOUSEHOLD; HUMAN; LEPROSY; MAJOR CLINICAL STUDY; SIMULATION; ADOLESCENT; ADULT; AGED; ALGORITHM; BIOLOGICAL MODEL; CHILD; CLUSTER ANALYSIS; CONTACT EXAMINATION; DISEASE TRANSMISSION; DOMINANT GENE; FAMILY SIZE; FEMALE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED; RECESSIVE GENE; RISK FACTOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; BANGLADESH; CHILD; CLUSTER ANALYSIS; CONTACT TRACING; FAMILY CHARACTERISTICS; FEMALE; GENES, DOMINANT; GENES, RECESSIVE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEPROSY; MALE; MIDDLE AGED; MODELS, GENETIC; RISK FACTORS; YOUNG ADULT;

EID: 78649505836     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014061     Document Type: Article

References (36)

1. WHO (2009) Global leprosy situation, 2009. Weekly Epidemiological Record 84: 333-340.
2. WHO (1998) WHO Expert Committee on Leprosy. World Health Organ Tech Rep Ser 874: 1-43.
3. Bagshawe A, Scott GC, Russell DA, Wigley SC, Merianos A, et al. (1989) Bcg Vaccination in Leprosy - Final Results of the Trial in Karimui, Papua-New- Guinea, 1963-79. Bulletin of the World Health Organization 67: 389-399.
4. Bakker MI, Hatta M, Kwenang A, Klatser PR, Oskam L (2002) Epidemiology of leprosy on five isolated islands in the Flores Sea, Indonesia. Tropical Medicine & International Health 7: 780-787.
5. Bakker MI, May L, Hatta M, Kwenang A, Klatser PR, et al. (2005) Genetic, household and spatial clustering of leprosy on an island in Indonesia: a population-based study. BMC Medical Genetics 6: 40.
6. Fine PE, Sterne JA, Ponnighaus JM, Bliss L, Saui J, et al. (1997) Household and dwelling contact as risk factors for leprosy in northern Malawi. American Journal of Epidemiology 146: 91-102.
7. Moet FJ, Pahan D, Schuring RP, Oskam L, Richardus JH (2006) Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with leprosy. Journal of Infectious diseases 193: 346-353.
8. Van Beers SM, Hatta M, Klatser PR (1999) Patient contact is the major determinant in incident leprosy: implications for future control. International Journal of Leprosy and Other Mycobacterial Diseases 67: 119-128.
9. Fine PE (1982) Leprosy: the epidemiology of a slow bacterium. Epidemiological Review 4: 161-188.
10. Noordeen SK (1985) The Epidemiology of leprosy. In: Hastings RC, ed.n Leprosy. Edinburgh: Churchill Livingstone.
11. Britton WJ, Lockwood DN (2004) Leprosy. The Lancet 363: 1209-1219.
12. Wade HW, Ledowsky V (1952) The leprosy epidemic at Nauru; a review, with data on the status since 1937. International Journal of Leprosy 20: 1-29.
13. Meima A, Smith WC, van Oortmarssen GJ, Richardus JH, Habbema JD (2004) The future incidence of leprosy: a scenario analysis. Bulletin of the World Health Organisation 82: 373-380.
14. Abel L, Vu DL, Oberti J, Nguyen VT, Van VC, et al. (1995) Complex segregation analysis of leprosy in southern Vietnam. Genetic Epidemiology 12: 63-82.
15. Shields ED, Russell DA, Pericak-Vance MA (1987) Genetic epidemiology of the susceptibility to leprosy. Journal of Clinical Investigation 79: 1139-1143.
16. Mira MT, Alcais A, Van Thuc N, Thai VH, Huong NT, et al. (2003) Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. Nature Genetics 33: 412-415.
17. Mira MT, Alcais A, Van Thuc N, Moraes MO, Di Flumeri C, et al. (2004) Susceptibility to leprosy is associated with PARK2 and PACRG. Nature.
18. Kerr-Pontes LR, Montenegro AC, Barreto ML, Werneck GL, Feldmeier H (2004) Inequality and leprosy in Northeast Brazil: an ecological study. International Journal of Epidemiology 33: 262-269.
19. Stolk WA, Swaminathan S, van Oortmarssen GJ, Das PK, Habbema JD (2003) Prospects for elimination of bancroftian filariasis by mass drug treatment in Pondicherry, India: a simulation study. Journal of Infectious Diseases 188: 1371-1381.
20. Van der Ploeg CPB, Van Vliet C, De Vlas SJ, Ndinya-Achola JO, Fransen L, et al. (1998) STDSIM: A Microsimulation Model for Decision Support in STD Control. Interfaces 28: 84-100.
21. Korenromp EL, Van Vliet C, Grosskurth H, Gavyole A, Van der Ploeg CP, et al. (2000) Model-based evaluation of single-round mass treatment of sexually transmitted diseases for HIV control in a rural African population. Aids 14: 573-593.
22. Smith T, Killeen GF, Maire N, Ross A, Molineaux L, et al. (2006) Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: Overview. American Journal of Tropical Medicin Hygiene 75: 1-10.
23. Ferguson NM, Cummings DAT, Cauchemez S, Fraser C, Riley S, et al. (2005) Strategies for containing an emerging influenza pandemic in Southeast Asia. Nature 437.
24. Fischer EAJ, Hemerik L, Van Roermund HJW, Van Asseldonk M, De Jong MCM (2005) Evaluation of detection methods for bovine tuberculosis (Mycobacterium bovis) using an individual based epidemiological model. Preventive Veterinary Medicine 67: 283-301.
25. Fischer EAJ, De Vlas SJ, Richardus JH, Habbema JDF (2008) MUSIDH, multiple use of simulated demographic histories, a novel method to reduce computation times in microsimulation models of infectious diseases. Computer Methods and Programs in Biomedicine.
26. Fischer EAJ, Pahan D, Chowdhury SK, Oskam L, Richardus JH (2008) The spatial distribution of leprosy in four villages in Bangladesh: An observational study. BMC Infectious Diseases 8.
27. Anonymous (2002) Report of the International Leprosy Association Technical Forum. Paris, France, 22-28 February 2002. International Journal of Leprosy and other Mycobacterial diseases 70(suppl.): S1-S62.
28. Nicholls PG, Croft RP, Richardus JH, Withington SG, Smith WC (2003) Delay in presentation, an indicator for nerve function status at registration and for treatment outcome-the experience of the Bangladesh Acute Nerve Damage Study cohort. Leprosy Review 74: 349-356.
29. Setia MS, Steinmaus C, Ho CS, Rutherford GW (2006) The role of BCG in prevention of leprosy: a meta-analysis. Lancet Infectious Diseases 6: 162-170.
30. Schuring RP, Richardus JH, Pahan D, Oskam L (2009) Protective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention. Vaccine.
31. WHO (2007) WHO/UNICEF Review of National Immunization Coverage 1980-2006 Bangladesh. WHO. 12 p.
32. UNSTATS (2000) Millenium Developments Goal Indicators.
33. Law AM, Kelton WD (2000) Chapter Twelve: Experimental Design, Sensitivity Analysis, and Optimization. Simulation Modeling and Analysis: McGraw-Hill Higher Education. pp 622-668.
34. Moet FJ, Schuring R, Pahan D, Oskam L, Richardus JH (2008) The prevalence of previously undiagnosed leprosy in the general population and in close contacts of leprosy patients in northwest Bangladesh. PLoS Neglected Tropical Diseases 2.
35. Hiebeler DE, Criner AK (2007) Partially mixed household epidemiological model with clustered resistant individuals. Physics Review E Statitistic Nonlinear Soft Matter Physics 75: 022901.
36. Moet FJ, Pahan D, Oskam L, Richardus JH (2008) Effectiveness of single dose rifampicin in preventing leprosy in close contacts of patients with newly diagnosed leprosy: cluster randomised controlled trial. British Medical Journal 336: 761-764.