What is a gene?-Revisited

Studies in History and Philosophy of Science Part C :Studies in History and Philosophy of Biological and Biomedical Sciences

Volumn 41, Issue 4, 2010, Pages 396-406

  Falk, Raphael ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Gene; Molecular biology: bottom up, top down; Reduction; Systems approach

Indexed keywords

ARTICLE; DNA SEQUENCE; GENE; GENOME; HISTORY; MOLECULAR BIOLOGY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHILOSOPHY;

BASE SEQUENCE; GENES; GENOME; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; MOLECULAR BIOLOGY; PHENOTYPE; PHILOSOPHY; SEQUENCE ANALYSIS, DNA;

EID: 78649503734     PISSN: 13698486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.shpsc.2010.10.014     Document Type: Article

References (57)

1. Barnes B., Dupré J. Genomes and what to make of them 2008, University of Chicago Press, Chicago.
2. Beadle G.W. Biochemical genetics. Chemical Review 1945, 37:15-96.
3. Beadle G.W., Tatum E.L. Genetic control of biochemical reactions in Neurospora. Proceedings of the National Academy of Science of the United States of America 1941, 27:499-506.
4. Benzer S. Fine structure of a genetic region in bacteriophage. Proceedings of the National Academy of Science of the United States of America 1955, 41(6):344-354.
5. Benzer, S. (1957). The elementary units of heredity. In B. Glass, & W. D. McElroy (Eds.), The chemical basis of heredity (pp. 70-93). Baltimore, MD: Johns Hopkins Press.
6. Benzer S., Champe S.P. A change from nonsense to sense in the genetic code. Proceedings of the National Academy of Science of the United States of America 1962, 48:1114-1121.
7. Benzer S., Freese E. Induction of specific mutations with 5-bromouracil. Proceedings of the National Academy of Science of the United States of America 1958, 44(2):112-119.
8. Crick F.H.C. On protein synthesis. Symposia of the Society for Experimental Biology 1958, 12:138-163.
9. Crick F.H.C., Barnett L., Brenner S., Watts-Tobin R.J. General nature of the genetic code for proteins. Nature 1961, 192(4809):1227-1232.
10. Dawkins R. The extended phenotype: The long reach of the gene 1982, Oxford University Press, Oxford & New York, NY.
11. Falk R. What is a gene?. Studies in the History and Philosophy of Science 1986, 17(2):133-173.
12. Falk R. Muller on development. Theory in Biosciences 1997, 116(4):349-366.
13. Falk R. The gene-a concept in tension. The concept of the gene in development and evolution: historical and epistemological perspectives 2000, 317-348. Cambridge University Press, Cambridge & New York, NY. P.J. Beurton, R. Falk, H.-J. Rheinberger (Eds.).
14. Falk R. Genetic analysis: A history of genetic thinking 2009, Cambridge University Press, Cambridge.
15. Falk R., Schwartz S. Morgan's hypothesis of the genetic control of development. Genetics 1993, 134(3):671-674.
16. Freese E. The specific mutagenic effect of base analogues. Journal of Molecular Biology 1959, 1:87-105.
17. Gerstein M.B., Bruce C., Rozowsky J.S., Zheng D., Du J., Korbel J.O., et al. What is a gene, post-ENCODE? History and updated definition. Genome Research 2007, 17(6):669-681.
18. Griffiths P.E., Neumann-Held E. The many faces of the gene. BioScience 1999, 49(8):656-662.
19. Griffiths P.E., Stotz K. Genes in the postgenomic era. Theoretical Medicine and Bioethics 2006, 27(6):499-521.
20. Helinski D.R., Yanofsky C. Correspondence between genetic data and the position of amino acid alteration in a protein. Proceedings of the National Academy of Science of the United States of America 1962, 48:173-183.
21. Holmes F.L. Seymour Benzer and the definition of the gene. The concept of the gene in development and evolution 2000, 115-155. Cambridge University Press, Cambridge & New York, NY. P.J. Beurton, R. Falk, H.-J. Rheinberger (Eds.).
22. Holmes F.L. Reconceiving the gene: Seymour Benzer's adventures in phage genetics 2006, Yale University Press, New Haven, CT & London.
23. Hutchins J.R.A., Toyoda Y., Hegemann B., Poser I., Heriche J.-K., Sykora M.M., et al. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 2010, 328(5978):593-599.
24. Hurtley S. Editing the genome. Science 2009, 324(5929):851.
25. Huxley J. Evolution: The modern synthesis 1943, Harper & Row, New York, NY.
26. Jacob F., Monod J. Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology 1961, 3:318-356.
27. Johannsen W. Elemente der exakten Erblichkeitslehre 1909, Gustav Fischer, Jena.
28. Keller, E. F., & Harel, D. (2007). Beyond the gene. PLoS ONE, 2(11)e1231, 1231-1211.
29. Lewin B. Genes VIII 2004, Pearson Prentice Hall, Upper Saddle River, NJ.
30. Li J., Browning S., Mahal S.P., Oelschlegel A.M., Weissmann C. Darwinian evolution of prions in cell culture. Science 2010, 327(5967):869-872.
31. Lolle S.J., Victor J.L., Young J.M., Pruitt R.E. Genome-wide non-Mendelian inheritance of extra-genomic information in Arabidopsis. Nature 2005, 434(7032):505-509.
32. MacCorquodale K., Meehl P.E. On distinction between hypothetical constructs and intervening variables. Psychological Review 1948, 55:95-107.
33. Morgan T.H. Chromosomes and heredity. The American Naturalist 1910, 44:449-498.
34. Morgan T.H. Factors and unit characters in Mendelian heredity. The American Naturalist 1913, 47(553):5-16.
35. Morgan, T. H. (1934). The relation of genetics to physiology and medicine. In (1965). Nobel Lectures, Physiology or Medicine, 1922-1941. Amsterdam: Elsevier Publishing Company, 1965. http://nobelprize.org/nobel_organizations/nobelfoundation/publications/lectures/medicine.html.
36. Moss L. One, two (too?), many genes? (Book review). The Quarterly Review of Biology 2003, 78(1):57-67.
37. Moss L. What genes can't do 2003, MIT Press, Cambridge.
38. Muller H.J. Variation due to change in the individual gene. The American Naturalist 1922, 56:32-50.
39. Muller H.J. Artificial transmutation of the gene. Science 1927, 66:84-87.
40. Muller H.J. The gene. Proceedings of the Royal Society, London, series B 1947, 134:1-37.
41. Muller H.J. Evidence of the precision of genetic adaptation. The Harvey Lectures 1950, 43:165-229.
42. Genes in development: Re-reading the molecular paradigm 2006, Duke University Press, Durham & London. E.M. Neumann-Held, C. Rehmann-Sutter (Eds.).
43. Pennisi E. DNA's cast of thousands. Science 2003, 300(5617):282-285.
44. Pontecorvo G. Genetic formulation of gene structure and gene action. Advances in Enzymology 1952, 13:121-149.
45. Pontecorvo G. Trends in genetic analysis 1958, Columbia University Press, New York, NY.
46. Portin P. The elusive concept of the gene. Hereditas 2009, 146:112-117.
47. Rédei, G. P., Koncz, C., & Phillips, J. D. (2006). Changing images of the gene. In J. C. Hall, J. C. Dunlap, T. Friedmann, & V. v. Heyningen (Eds.), Advances in genetics (Vol. 56) (pp. 53-100). London, Oxford, Boston, MA & New York, NY: Academic Press.
48. Rheinberger, H.-J., & Müller-Wille, S. (2006). Gene. In E. N. Zalta (Ed.), The stanford encyclopedia of philosophy. (Spring 2006 Edition) http://plato.stanford.edu/archives/spr2006/entries/gene/.
49. Scherrer K., Jost J. Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology. Theory in Biosciences 2007, 126(2):65-113.
50. Scherrer K., Jost J. Response to commentaries on our paper gene and genon concept: coding versus regulation. Theory in Biosciences 2009, 128:171-177.
51. Schrödinger E. What is life? The physical aspect of the living cell 1944(1962), Cambridge University Press, Cambridge.
52. Stadler P.F., Prohaska S.J., Forst C.V., Krakauer D.C. Defining genes: A computational framework. Theory in Biosciences 2009, 128(3):165-170.
53. Stotz K., Griffiths P. Genes: philosophical analyses put to the test. History and Philosophy of the Life Sciences 2004, 26(Special issue Genes, genomes and genetic elements):5-28.
54. Timoféeff-Ressovsky N.W., Zimmer E.G., Delbrück M. Über die Natur der Genmutation und der Genstruktur. Nachrichten der Biologischen Gesellschaft für Wissenschaft, Göttingen 1935, 1:189-245.
55. Waters C.K. Genes made molecular. Philosophy of Science 1994, 61:163-185.
56. Waters, C. K. (2007). Molecular genetics. In E. N. Zalta (Ed.), Stanford Encyclopedia of Philosophy (Fall 2008 Edition). http://plato.stanford.edu/entries/molecular-genetics/.
57. Yanofsky C., Carlton B.C., Guest J.R., Helinski D.R., Henning U. On the colinearity of gene structure and protein structure. Proceedings of the National Academy of Science of the United States of America 1964, 51(2):266-272.