Structural and functional characterization of a human IgG monoclonal antiphospholipid antibody

Immunobiology

Volumn 216, Issue 1-2, 2011, Pages 145-151

  Prinz, Nadine ^a   Häuser, Friederike ^a   Lorenz, Mareike ^a   Lackner, Karl J ^a   von Landenberg, Philipp ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Antiphospholipid antibodies; Human monoclonal antibodies; IgG

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HL5B; MONOCLONAL ANTIBODY HL7G; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ADULT; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BRAIN EMBOLISM; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GERM LINE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; MICROEMBOLISM; PRIORITY JOURNAL; PROTEIN FUNCTION; RECURRENT DISEASE; SOMATIC MUTATION; T LYMPHOCYTE;

ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; CARDIOLIPINS; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; T-LYMPHOCYTES, HELPER-INDUCER; THROMBOPLASTIN;

EID: 78649499335     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.05.001     Document Type: Article

References (37)

1. Galli M., Comfurius P., Maassen C., Hemker H.C., de Baets M.H., van Breda-Vriesman P.J., Barbui T., Zwaal R.F., Bevers E.M. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990, 335:1544.
2. Harris E.N., Gharavi A.E., Boey M.L., Patel B.M., Mackworth-Young C.G., Loizou S., Hughes G.R. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983, 2:1211.
3. Harris E.N., Pierangeli S.S., Gharavi A.E. Diagnosis of the antiphospholipid syndrome: a proposal for use of laboratory tests. Lupus 1998, 7(Suppl. 2):S144.
4. Kandiah D.A., Sali A., Sheng Y., Victoria E.J., Marquis D.M., Coutts S.M., Krilis S.A. Current insights into the "antiphospholipid" syndrome: clinical, immunological, and molecular aspects. Adv. Immunol. 1998, 70:507.
5. McNeil H.P., Simpson R.J., Chesterman C.N., Krilis S.A. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. U.S.A. 1990, 87:4120.
6. Roubey R.A., Hoffman M. From antiphospholipid syndrome to antibody-mediated thrombosis. Lancet 1997, 350:1491.
7. Keeling D.M., Wilson A.J., Mackie I.J., Machin S.J., Isenberg D.A. Some 'antiphospholipid antibodies' bind to beta 2-glycoprotein I in the absence of phospholipid. Br. J. Haematol. 1992, 82:571.
8. Viard J.P., Amoura Z., Bach J.F. Association of anti-beta 2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am. J. Med. 1992, 93:181.
9. Matsuura E., Igarashi Y., Yasuda T., Triplett D.A., Koike T. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med. 1994, 179:457.
10. Ichikawa K., Khamashta M.A., Koike T., Matsuura E., Hughes G.R. beta 2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum. 1994, 37:1453.
11. Roubey R.A., Eisenberg R.A., Harper M.F., Winfield J.B. "Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding. J. Immunol. 1995, 154:954.
12. Arvieux J., Pouzol P., Roussel B., Jacob M.C., Colomb M.G. Lupus-like anticoagulant properties of murine monoclonal antibodies to beta 2-glycoprotein I. Br. J. Haematol. 1992, 81:568.
13. von Landenberg C., Lackner K.J., von Landenberg P., Lang B., Schmitz G. Isolation and characterization of two human monoclonal anti-phospholipid IgG from patients with autoimmune disease. J. Autoimmun. 1999, 13:215.
14. Blank M., Faden D., Tincani A., Kopolovic J., Goldberg I., Gilburd B., Allegri F., Balestrieri G., Valesini G., Shoenfeld Y. Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J. Autoimmun. 1994, 7:441.
15. Levy Y., Ziporen L., Gilburd B., George J., Polak-Charcon S., Amital H., Cledes J., Youinou P., Shoenfeld Y. Membranous nephropathy in primary antiphospholipid syndrome: description of a case and induction of renal injury in SCID mice. Hum. Antibodies Hybridomas 1996, 7:91.
16. Mizutani H., Engelman R.W., Kinjoh K., Kurata Y., Ikehara S., Good R.A. Prevention and induction of occlusive coronary vascular disease in autoimmune (W/B)F1 mice by haploidentical bone marrow transplantation: possible role for anticardiolipin autoantibodies. Blood 1993, 82:3091.
17. Wilson W.A., Gharavi A.E., Koike T., Lockshin M.D., Branch D.W., Piette J.C., Brey R., Derksen R., Harris E.N., Hughes G.R., Triplett D.A., Khamashta M.A. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 1999, 42:1309.
18. Miyakis S., Lockshin M.D., Atsumi T., Branch D.W., Brey R.L., Cervera R., Derksen R.H., de Groot P.G., Koike T., Meroni P.L., Reber G., Shoenfeld Y., Tincani A., Vlachoyiannopoulos P.G., Krilis S.A. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006, 4:295.
19. Doring Y., Hurst J., Lorenz M., Prinz N., Clemens N., Drechsler M.D., Bauer S., Chapman J., Shoenfeld Y., Blank M., Lackner K.J., von Landenberg P. Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8. Immunobiology 2009.
20. Ovstebo R., Haug K.B., Lande K., Kierulf P. PCR-based calibration curves for studies of quantitative gene expression in human monocytes: development and evaluation. Clin. Chem. 2003, 49:425.
21. Simitsopoulou M., Roilides E., Dotis J., Dalakiouridou M., Dudkova F., Andreadou E., Walsh T.J. Differential expression of cytokines and chemokines in human monocytes induced by lipid formulations of amphotericin B. Antimicrob. Agents Chemother. 2005, 49:1397.
22. (-Delta Delta C(T)) Method. Methods 2001, 25:402.
23. Matsuda F., Shin E.K., Nagaoka H., Matsumura R., Haino M., Fukita Y., Taka-ishi S., Imai T., Riley J.H., Anand R., et al. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat. Genet. 1993, 3:88.
24. Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P. Human immunoglobulin D segments encoded in tandem multigenic families. Nature 1981, 294:631.
25. Buluwela L., Albertson D.G., Sherrington P., Rabbitts P.H., Spurr N., Rabbitts T.H. The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35kb of the C mu gene and identification of a new DH locus. EMBO J. 1988, 7:2003.
26. Mattila P.S., Schugk J., Wu H., Makela O. Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus. Eur. J. Immunol. 1995, 25:2578.
27. Hughes G.R. Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br. Med. J. (Clin. Res. Ed.) 1983, 287:1088.
28. Gharavi A.E., Harris E.N., Asherson R.A., Hughes G.R. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann. Rheum. Dis. 1987, 46:1.
29. Sammaritano L.R., Ng S., Sobel R., Lo S.K., Simantov R., Furie R., Kaell A., Silverstein R., Salmon J.E. Anticardiolipin IgG subclasses: association of IgG2 with arterial and/or venous thrombosis. Arthritis Rheum. 1997, 40:1998.
30. Hayakawa K., Asano M., Shinton S.A., Gui M., Allman D., Stewart C.L., Silver J., Hardy R.R. Positive selection of natural autoreactive B cells. Science 1999, 285:113.
31. Lopez-Pedrera C., Buendia P., Aguirre M.A., Velasco F., Cuadrado M.J. Antiphospholipid syndrome and tissue factor: a thrombotic couple. Lupus 2006, 15:161.
32. Pierangeli S.S., Vega-Ostertag M., Harris E.N. Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies. Thromb. Res. 2004, 114:467.
33. Wolberg A.S., Roubey R.A. Mechanisms of autoantibody-induced monocyte tissue factor expression. Thromb. Res. 2004, 114:391.
34. Amengual O., Atsumi T., Khamashta M.A., Hughes G.R. The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb. Haemost. 1998, 79:276.
35. Cuadrado M.J., Lopez-Pedrera C., Khamashta M.A., Camps M.T., Tinahones F., Torres A., Hughes G.R., Velasco F. Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis Rheum. 1997, 40:834.
36. Chukwuocha R.U., Zhu M., Cho C.S., Visvanathan S., Hwang K.K., Rahman A., Chen P.P. Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies. Mol. Immunol. 2002, 39:299.
37. Giles I., Pericleous C., Liu X., Ehsanullah J., Clarke L., Brogan P., Newton-West M., Swerlick R., Lambrianides A., Chen P., Latchman D., Isenberg D., Pierangeli S., Rahman A. Thrombin binding predicts the effects of sequence changes in a human monoclonal antiphospholipid antibody on its in vivo biologic actions. J. Immunol. 2009, 182:4836.