The L2a element is a mouse CD8 silencer that interacts with MAR-binding proteins SATB1 and CDP

Molecular Immunology

Volumn 48, Issue 1-3, 2010, Pages 153-163

  Yao, Xin ^a   Nie, Hui ^a   Rojas, Ingrid C ^a   Harriss, June V ^a   Maika, Shanna D ^a   Gottlieb, Paul D ^a   Rathbun, Gary ^a   Tucker, Philip W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

CD8; SATB1; Transcriptional silencing; Transgenic mice

Indexed keywords

CD8ALPHA ANTIGEN; CYTIDINE DIPHOSPHATE; L2A ELEMENT; NUCLEAR MATRIX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CD4 CD8 RATIO; CELL POPULATION; EMBRYO; FEMALE; GENE DELETION; GENE EXPRESSION; GENE SILENCING; HUMAN; INGUINAL LYMPH NODE; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REPORTER GENE; SPLEEN CELL; T LYMPHOCYTE; THYMOCYTE; TRANSGENE;

ANIMALS; ANTIGENS, CD8; BASE SEQUENCE; CELL SEPARATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MATRIX ATTACHMENT REGION BINDING PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRESSOR PROTEINS; SILENCER ELEMENTS, TRANSCRIPTIONAL;

MUS MUSCULUS;

EID: 78649498612     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.08.014     Document Type: Article

References (47)

1. Alvarez J.D., Yasui D.H., Niida H., Joh T., Loh D.Y., Kohwi-Shigematsu T. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev 2000, 14:521-535.
2. Banan M., Rojas I.C., Lee W.H., King H.L., Harriss J.V., Kobayashi R., Webb C.F., Gottlieb P.D. Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene. J Biol Chem 1997, 272:18440-18452.
3. Bilic I., Koesters C., Unger B., Sekimata M., Hertweck A., Maschek R., Wilson C.B., Ellmeier W. Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat Immunol 2006, 7:392-400.
4. Blasquez V.C., Sperry A.O., Cockerill P.N., Garrard W.T. Protein:DNA interactions at chromosomal loop attachment sites. Genome 1989, 31:503-509.
5. Cai S., Han H.J., Kohwi-Shigematsu T. Tissue-specific nuclear architecture and gene expression regulated by SATB1. Nat Genet 2003, 34:42-51.
6. Cai S., Lee C.C., Kohwi-Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 2006, 38:1278-1288.
7. Cheroutre H., Lambolez F. The thymus chapter in the life of gut-specific intra epithelial lymphocytes. Curr Opin Immunol 2008, 20:185-191.
8. +CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 2003, 100:5324-5329.
9. Dickinson L.A., Joh T., Kohwi Y., Kohwi-Shigematsu T. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell 1992, 70:631-645.
10. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983, 11:1475-1489.
11. Ellmeier W., Sunshine M.J., Losos K., Hatam F., Littman D.R. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 1997, 7:537-547.
12. Ellmeier W., Sunshine M.J., Losos K., Littman D.R. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 1998, 9:485-496.
13. Ellmeier W., Sunshine M.J., Maschek R., Littman D.R. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 2002, 16:623-634.
14. Feik N., Bilic I., Tinhofer J., Unger B., Littman D.R., Ellmeier W. Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol 2005, 174:1513-1524.
15. Galande S., Purbey P.K., Notani D., Kumar P.P. The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1. Curr Opin Genet Dev 2007, 17:408-414.
16. Garefalaki A., Coles M., Hirschberg S., Mavria G., Norton T., Hostert A., Kioussis D. Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity 2002, 16:635-647.
17. Han H.J., Russo J., Kohwi Y., Kohwi-Shigematsu T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 2008, 452:187-193.
18. Hart C.M., Laemmli U.K. Facilitation of chromatin dynamics by SARs. Curr Opin Genet Dev 1998, 8:519-525.
19. Hostert A., Garefalaki A., Mavria G., Tolaini M., Roderick K., Norton T., Mee P.J., Tybulewicz V.L., Coles M., Kioussis D. Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity 1998, 9:497-508.
20. Hostert A., Tolaini M., Festenstein R., McNeill L., Malissen B., Williams O., Zamoyska R., Kioussis D. A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J Immunol 1997, 158:4270-4281.
21. Hostert A., Tolaini M., Roderick K., Harker N., Norton T., Kioussis D. A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 1997, 7:525-536.
22. Kioussis D., Ellmeier W. Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol 2002, 2:909-919.
23. Kieffer L.J., Greally J.M., Landres I., Nag S., Yuko N., Kohwi-Shigematsu T., Kavathas P.B. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. J Immunol 2002, 168:3915-3922.
24. Kumar P.P., Bischof O., Purbey P.K., Notani D., Urlaub H., Dejean A., Galande S. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol 2007, 9:45-56.
25. Landry D.B., Engel J.D., Sen R. Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences. J Exp Med 1993, 178:941-949.
26. Lee W.H., Banan M., Harriss J.V., Hwang I., Woodward E., Youn H.J., Gottlieb P.D. Cis-acting DNA elements and cell type-specific nuclear proteins which may play a role in regulation of mouse CD8 alpha (Lyt-2) gene transcription. Int Immunol 1994, 6:1307-1321.
27. Liu J., Barnett A., Neufeld E.J., Dudley J.P. Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Mol Cell Biol 1999, 19:4918-4926.
28. Luong M.X., van der Meijden C.M., Xing D., Hesselton R., Monuki E.S., Jones S.N., Lian J.B., Stein J.L., Stein G.S., Neufeld E.J., van Wijnen A.J. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol 2002, 22:1424-1437.
29. Maeda T., Maeda M., Stewart A.F. TEF-1 transcription factors regulate activity of the mouse mammary tumor virus LTR. Biochem Biophys Res Commun 2002, 296:1279-1285.
30. Nakauchi H., Tagawa M., Nolan G.P., Herzenberg L.A. Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2. Nucleic Acids Res 1987, 15:4337-4347.
31. Nepveu A. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development. Gene 2001, 270:1-15.
32. Nie H., Maika S.D., Tucker P.W., Gottlieb P.D. A role for SATB1, a nuclear matrix association region-binding protein, in the development of CD8SP thymocytes and peripheral T lymphocytes. J Immunol 2005, 174:4745-4752.
33. Nie H., Yao X., Maika S.D., Tucker P.W. SATB1 is required for CD8 coreceptor reversal. Mol Immunol 2008, 46:207-211.
34. Owen M.J., Jenkinson E.J., Brown M.H., Sewell W.A., Krissansen G.W., Crumpton M.J., Owen J.J. Murine CD2 gene expression during fetal thymus ontogeny. Eur J Immunol 1988, 18:187-189.
35. Pavan Kumar P., Purbey P.K., Sinha C.K., Notani D., Limaye A., Jayani R.S., Galande S. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Mol Cell 2006, 22:231-243.
36. Sander M., Hsieh T.S. Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site. Nucleic Acids Res 1985, 13:1057-1072.
37. Sansregret L., Nepveu A. The multiple roles of CUX1: insights from mouse models and cell-based assays. Gene 2008, 412:84-94.
38. Sawada S., Scarborough J.D., Killeen N., Littman D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 1994, 77:917-929.
39. Sayre P.H., Chang H.C., Hussey R.E., Brown N.R., Richardson N.E., Spagnoli G., Clayton L.K., Reinherz E.L. Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes. Proc Natl Acad Sci U S A 1987, 84:2941-2945.
40. Scheuermann R.H., Garrard W.T. MARs of antigen receptor and co-receptor genes. Crit Rev Eukaryot Gene Exp 1999, 9:295-310.
41. Sheldon L.A., Becker M., Smith C.L. Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter. J Biol Chem 2001, 276:32423-32426.
42. Sinclair A.M., Lee J.A., Goldstein A., Xing D., Liu S., Ju R., Tucker P.W., Neufeld E.J., Scheuermann R.H. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood 2001, 98:3658-3667.
43. Singer A., Adoro S., Park J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 2008, 8:788-801.
44. Traver D., Akashi K., Manz M., Merad M., Miyamoto T., Engleman E.G., Weissman I.L. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 2000, 290:2152-2154.
45. Wang Z., Goldstein A., Zong R.T., Lin D., Neufeld E.J., Scheuermann R.H., Tucker P.W. Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol 1999, 19:284-295.
46. Yasui D., Miyano M., Cai S., Varga-Weisz P., Kohwi-Shigematsu T. SATB1 targets chromatin remodelling to regulate genes over long distances. Nature 2002, 419:641-645.
47. Zhu Q., Maitra U., Johnston D., Lozano M., Dudley J.P. The homeodomain protein CDP regulates mammary-specific gene transcription and tumorigenesis. Mol Cell Biol 2004, 24:4810-4823.