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Volumn 11, Issue 4, 2010, Pages 72-78

Therapy of Alzheimer's dementia: Status quo and future perspectives;Therapie der Alzheimer-demenz: Status quo und zukunftsperspektiven

Author keywords

Alzheimer's dementia; Dementia; Treatment

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

EID: 78649493134     PISSN: 16081587     EISSN: 16809440     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (65)
  • 1
    • 78649487274 scopus 로고    scopus 로고
    • Available from: gesehen 4.12.2008
    • Österreichische Alzheimer Liga. Available from: http://www. alzheimer-liga.at/aufgaben.html [gesehen 4.12.2008].
  • 3
    • 78649493393 scopus 로고    scopus 로고
    • gesehen 4.12.2008
    • National Institute on Aging. The Seven Warning Signs of Alzheimer's Disease. http://www.nia.nih.gov/Alzheimers/Publications/sevensigns.htm [gesehen 4.12.2008].
    • The Seven Warning Signs of Alzheimer's Disease
  • 4
    • 78649477511 scopus 로고    scopus 로고
    • Demenzerkrankungen
    • Gastpar MT, Kasper S, Linden M (Hrsg). Springer-Verlag, Wien-New York
    • Hellweg R. Demenzerkrankungen. In: Gastpar MT, Kasper S, Linden M (Hrsg). Psychiatrie und Psychotherapie. Springer-Verlag, Wien-New York, 2003; 37-44.
    • (2003) Psychiatrie und Psychotherapie , pp. 37-44
    • Hellweg, R.1
  • 5
    • 52449089987 scopus 로고    scopus 로고
    • Thirty years of Alzheimer's disease genetics: The implications of systematic meta-analyses
    • Bertram L, Tanzi RE. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 2008; 9: 768-78.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 768-778
    • Bertram, L.1    Tanzi, R.E.2
  • 6
    • 42149107502 scopus 로고    scopus 로고
    • Genetic aspects of Alzheimer disease
    • Bird TD. Genetic aspects of Alzheimer disease. Genet Med 2008; 10: 231-9.
    • (2008) Genet Med , vol.10 , pp. 231-239
    • Bird, T.D.1
  • 8
    • 38349146483 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease: Molecular mechanisms and therapeutic opportunities
    • Cedazo-Minguez A. Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities. J Cell Mol Med 2007; 11: 1227-38.
    • (2007) J Cell Mol Med , vol.11 , pp. 1227-1238
    • Cedazo-Minguez, A.1
  • 9
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
    • Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L Jr, Eckman C, Golde TE, Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 1994; 264: 1336-40.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3    Odaka, A.4    Otvos Jr., L.5    Eckman, C.6    Golde, T.E.7    Younkin, S.G.8
  • 10
    • 64149132721 scopus 로고    scopus 로고
    • Amyloid beta -protein toxicity and the pathogenesis of Alzheimer's disease
    • Yankner BA, Lu T. Amyloid beta -protein toxicity and the pathogenesis of Alzheimer's disease. J Biol Chem 2009; 284: 4755-9.
    • (2009) J Biol Chem , vol.284 , pp. 4755-4759
    • Yankner, B.A.1    Lu, T.2
  • 11
    • 48749090279 scopus 로고    scopus 로고
    • Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies
    • Alonso AC, Li B, Grundke-Iqbal I, Iqbal K. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies. Curr Alzheimer Res 2008; 5: 375-84.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 375-384
    • Alonso, A.C.1    Li, B.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 12
    • 0036318769 scopus 로고    scopus 로고
    • The cholinergic pathology in Alzheimer's disease - Discrepancies between clinical experience and pathophysiological findings
    • Frolich L. The cholinergic pathology in Alzheimer's disease - discrepancies between clinical experience and pathophysiological findings. J Neural Transm 2002; 109: 1003-13.
    • (2002) J Neural Transm , vol.109 , pp. 1003-1013
    • Frolich, L.1
  • 13
    • 45249087489 scopus 로고    scopus 로고
    • Functional consequences of locus coeruleus degeneration in Alzheimer's disease
    • Weinshenker D. Functional consequences of locus coeruleus degeneration in Alzheimer's disease. Curr Alzheimer Res 2008; 5: 342-5.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 342-345
    • Weinshenker, D.1
  • 15
    • 38549149803 scopus 로고    scopus 로고
    • A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders
    • Figiel G, Sadowsky C. A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders. Curr Med Res Opin 2008; 24: 157-66.
    • (2008) Curr Med Res Opin , vol.24 , pp. 157-166
    • Figiel, G.1    Sadowsky, C.2
  • 16
    • 0032928788 scopus 로고    scopus 로고
    • Clinical profile of donepezil in the treatment of Alzheimer's disease
    • Doody RS. Clinical profile of donepezil in the treatment of Alzheimer's disease. Gerontology 1999; 45 (Suppl 1): 23-32.
    • (1999) Gerontology , vol.45 , Issue.SUPPL. 1 , pp. 23-32
    • Doody, R.S.1
  • 19
    • 30344485665 scopus 로고    scopus 로고
    • Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    • Lane RM, Potkin SG, Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int J Neuropsychopharmacol 2006; 9: 101-24.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 101-124
    • Lane, R.M.1    Potkin, S.G.2    Enz, A.3
  • 20
    • 0036993145 scopus 로고    scopus 로고
    • Butyrylcholinesterase: An important new target in Alzheimer's disease therapy
    • Greig NH, Lahiri DK, Sambamurti K. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. Int Psychogeriatr 2002; 14 (Suppl 1): 77-91.
    • (2002) Int Psychogeriatr , vol.14 , Issue.SUPPL. 1 , pp. 77-91
    • Greig, N.H.1    Lahiri, D.K.2    Sambamurti, K.3
  • 21
    • 18944405809 scopus 로고    scopus 로고
    • Rivastigmine for subcortical vascular dementia
    • Roman GC. Rivastigmine for subcortical vascular dementia. Expert Rev Neurother 2005; 5: 309-13.
    • (2005) Expert Rev Neurother , vol.5 , pp. 309-313
    • Roman, G.C.1
  • 22
    • 33847390281 scopus 로고    scopus 로고
    • Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: A case control study
    • Rozzini L, Chilovi BV, Bertoletti E, Conti M, Delrio I, Trabucchi M, Padovani A. Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: a case control study. Am J Alzheimers Dis Other Demen 2007; 22: 42-7.
    • (2007) Am J Alzheimers Dis Other Demen , vol.22 , pp. 42-47
    • Rozzini, L.1    Chilovi, B.V.2    Bertoletti, E.3    Conti, M.4    Delrio, I.5    Trabucchi, M.6    Padovani, A.7
  • 25
    • 47849098036 scopus 로고    scopus 로고
    • Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer's disease
    • Emre M, Mecocci P, Stender K. Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer's disease. J Alzheimers Dis 2008; 14: 193-9.
    • (2008) J Alzheimers Dis , vol.14 , pp. 193-199
    • Emre, M.1    Mecocci, P.2    Stender, K.3
  • 28
    • 54249154591 scopus 로고    scopus 로고
    • Depression in Alzheimer's disease: Phenomenology, clinical correlates and treatment
    • Starkstein SE, Mizrahi R, Power BD. Depression in Alzheimer's disease: phenomenology, clinical correlates and treatment. Int Rev Psychiatry 2008; 20: 382-8.
    • (2008) Int Rev Psychiatry , vol.20 , pp. 382-388
    • Starkstein, S.E.1    Mizrahi, R.2    Power, B.D.3
  • 30
    • 33750221838 scopus 로고    scopus 로고
    • Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: Haloperidol vs. quetiapine
    • Savaskan E, Schnitzler C, Schroder C, Cajochen C, Müller-Spahn F, Wirz-Justice A. Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine. Int J Neuropsychopharmacol 2006; 9: 507-16.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 507-516
    • Savaskan, E.1    Schnitzler, C.2    Schroder, C.3    Cajochen, C.4    Müller-Spahn, F.5    Wirz-Justice, A.6
  • 31
    • 14644396191 scopus 로고    scopus 로고
    • Do atypical antipsychotics cause stroke?
    • Herrmann N, Lanctot KL. Do atypical antipsychotics cause stroke? CNS Drugs 2005; 19: 91-103.
    • (2005) CNS Drugs , vol.19 , pp. 91-103
    • Herrmann, N.1    Lanctot, K.L.2
  • 32
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials
    • Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005; 294: 1934-43.
    • (2005) JAMA , vol.294 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 34
    • 35648958264 scopus 로고    scopus 로고
    • Light treatment for neuropsychiatric behaviors in Alzheimer's disease
    • Dowling GA, Graf CL, Hubbard EM, Luxenberg JS. Light treatment for neuropsychiatric behaviors in Alzheimer's disease. West J Nurs Res 2007; 29: 961-75.
    • (2007) West J Nurs Res , vol.29 , pp. 961-975
    • Dowling, G.A.1    Graf, C.L.2    Hubbard, E.M.3    Luxenberg, J.S.4
  • 35
    • 35948953508 scopus 로고    scopus 로고
    • Nonpharmacological cognitive interventions in aging and dementia
    • Acevedo A, Loewenstein DA. Nonpharmacological cognitive interventions in aging and dementia. J Geriatr Psychiatry Neurol 2007; 20: 239-49.
    • (2007) J Geriatr Psychiatry Neurol , vol.20 , pp. 239-249
    • Acevedo, A.1    Loewenstein, D.A.2
  • 37
    • 48949085739 scopus 로고    scopus 로고
    • Amyloid-beta immunisation for Alzheimer's disease
    • Wisniewski T, Konietzko U. Amyloid-beta immunisation for Alzheimer's disease. Lancet Neurol 2008; 7: 805-11.
    • (2008) Lancet Neurol , vol.7 , pp. 805-811
    • Wisniewski, T.1    Konietzko, U.2
  • 39
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792- Associated meningoencephalitis
    • Pride M, Seubert P, Grundman M, Hagen M, Eldridge J, Black RS. Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792- associated meningoencephalitis. Neurodegener Dis 2008; 5: 194-6.
    • (2008) Neurodegener Dis , vol.5 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5    Black, R.S.6
  • 41
    • 43649098717 scopus 로고    scopus 로고
    • Developing injectable immunoglobulins to treat cognitive impairment in Alzheimer's disease
    • Steinitz M. Developing injectable immunoglobulins to treat cognitive impairment in Alzheimer's disease. Expert Opin Biol Ther 2008; 8: 633-42.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 633-642
    • Steinitz, M.1
  • 42
    • 54249156984 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies
    • Sigurdsson EM. Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. J Alzheimers Dis 2008; 15: 157-68.
    • (2008) J Alzheimers Dis , vol.15 , pp. 157-168
    • Sigurdsson, E.M.1
  • 43
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci 2007; 27: 9115-29.
    • (2007) J Neurosci , vol.27 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 44
    • 46749097518 scopus 로고    scopus 로고
    • Inhibition and modulation of gamma-secretase for Alzheimer's disease
    • Wolfe MS. Inhibition and modulation of gamma-secretase for Alzheimer's disease. Neurotherapeutics 2008; 5: 391-8.
    • (2008) Neurotherapeutics , vol.5 , pp. 391-398
    • Wolfe, M.S.1
  • 47
    • 33745562109 scopus 로고    scopus 로고
    • Tramiprosate
    • Barc
    • Wright TM. Tramiprosate. Drugs Today (Barc) 2006; 42: 291-8.
    • (2006) Drugs Today , vol.42 , pp. 291-298
    • Wright, T.M.1
  • 50
    • 44449179863 scopus 로고    scopus 로고
    • Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease
    • Takeuchi M, Yamagishi S. Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease. Curr Pharm Des 2008; 14: 973-8.
    • (2008) Curr Pharm Des , vol.14 , pp. 973-978
    • Takeuchi, M.1    Yamagishi, S.2
  • 55
    • 59449097789 scopus 로고    scopus 로고
    • Methylthioninium chloride reverses cognitive deficits induced by scopolamine: Comparison with rivastigmine
    • Berl
    • Deiana S, Harrington CR, Wischik CM, Riedel G. Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine. Psychopharmacology (Berl) 2009; 202: 53-65.
    • (2009) Psychopharmacology , vol.202 , pp. 53-65
    • Deiana, S.1    Harrington, C.R.2    Wischik, C.M.3    Riedel, G.4
  • 60
    • 33847183893 scopus 로고    scopus 로고
    • Glucocorticoids may initiate Alzheimer's disease: A potential therapeutic role for mifepristone (RU-486)
    • Dhikav V, Anand KS. Glucocorticoids may initiate Alzheimer's disease: a potential therapeutic role for mifepristone (RU-486). Med Hypotheses 2007; 68: 1088-92.
    • (2007) Med Hypotheses , vol.68 , pp. 1088-1092
    • Dhikav, V.1    Anand, K.S.2
  • 64
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, Seely L, Hung D. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 2008; 372: 207-15.
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7    Hung, D.8
  • 65
    • 39049152973 scopus 로고    scopus 로고
    • An update on huperzine A as a treatment for Alzheimer's disease
    • Little JT, Walsh S, Aisen PS. An update on huperzine A as a treatment for Alzheimer's disease. Expert Opin Investig Drugs 2008; 17: 209-15.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 209-215
    • Little, J.T.1    Walsh, S.2    Aisen, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.