Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: Results of a Spanish multicenter study

Transfusion and Apheresis Science

Volumn 43, Issue 3, 2010, Pages 299-303

  Rubia, Javier de la ^a   Moscardó, Federico ^a   Gómez, María J ^b   Guardia, Ramón ^c   Rodríguez, Pilar ^d   Sebrango, Ana ^e   Zamora, Concepción ^f   Debén, Guillermo ^g   Goterris, Rosa ^h   López, Rafaela ⁱ   Peña, Francisco ^j   Pujol, Misericordia ^k   Vidaller, Antonio ^l   Río Garma, Julio del ^m   Sanz, Miguel A ^a  

^a UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR   (Spain)

^b HOSPITAL DE MÓSTOLES   (Spain)

^c ICO   (Spain)

^d Hospital Central   (Spain)

^e HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^f HOSPITAL RAMÓN Y CAJAL   (Spain)

^g HOSPITAL JUAN CANALEJO   (Spain)

^h HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

ⁱ HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^j HOSPITAL DO MEIXOEIRO   (Spain)

^k HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^l HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^m Complejo Hospitalario de Orense ^*  (Spain)

more..

Author keywords

Efficacy; Rituximab; Safety; Thrombotic thrombocytopenic purpura

Indexed keywords

PREDNISOLONE; RITUXIMAB;

ADULT; AGED; ARTICLE; CAUSE OF DEATH; CHILL; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; PLASMAPHERESIS; PRURITUS; REFRACTORY THROMBOCYTOPENIA; RELAPSE; REMISSION; SPAIN; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 78649464512     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2010.09.018     Document Type: Article

References (27)

1. George J. Thrombotic thrombocytopenic purpura. New Engl J Med 2006, 354:1927-1935.
2. Moake J.L. Journey in reverse: TTP from bedside to blood bank to bench. J Clin Apher 2007, 22:37-49.
3. Rock G.A., Shumak K.H., Buskard N.A., et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991, 325:393-397.
4. Rock G., Porta C., Bobbio-Pallavicini E. Thrombotic thrombocytopenic purpura treatment in year 2000. Haematologica 2000, 85:410-419.
5. Veyradier A., Meyer D. Thrombotic thrombocytopenic purpura and its diagnosis. J Thromb Haem 2005, 3:2420-2427.
6. Sadler J. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood 2008, 12:11-18.
7. Kappers-Klunne M.C., Wijermans P., Fijnheer R., et al. Splenectomy for the treatment of thrombotic thrombocytopenic purpura. Br J Haematol 2005, 130:768-776.
8. O'Connor N.T., O'Shea M.J., Hill L.F. Vincristine for thrombotic thrombocytopenic purpura [letter]. Lancet 1992, 340:490.
9. Durand J.M., Lefevre P., Kaplanski G., et al. Vincristine for thrombotic thrombocytopenic purpura. Lancet 1992, 340:977-978.
10. Durand J.M., Lefevre P., Kaplanski G., et al. Ineffectiveness of high-dose intravenous gammaglobulin infusion in thrombotic thrombocytopenic purpura [letter]. Am J Hematol 1993, 42:234.
11. Udvardy M., Rak K. Cyclophosphamide for chronic relapsing thrombotic thrombocytopenic purpura. Lancet 1990, 336:1508-1509.
12. Crowther M.A., Heddle N., Hayward C.P., et al. Splenectomy done during hematologic remission to prevent relapse in patients with thrombotic thrombocytopenic purpura. Ann Intern Med 1996, 125:294-296.
13. Garvey B. Rituximab in the treatment of autoimmune haematological disorders. Br J Haematol 2008, 141:149-169.
14. Fakhouri F., Vernant J.P., Veyradier A., et al. Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases. Blood 2005, 106:1932-1937.
15. Franchini M., Veneri D., Lippi G., et al. The efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders. Thromb Haem 2006, 96:119-125.
16. Scully M., Cohen H., Cavenagh J., et al. Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13. Br J Haematol 2007, 136:451-461.
17. Del Río-Garma J., Alvarez-Larrán A., Martínez C., et al. Methylene blue-photoinactivated plasma versus quarantine fresh frozen plasma in thrombotic thrombocytopenic purpura: a multicentric, prospective cohort study. Br J Haematol 2008, 143:39-45.
18. Gray R.J. A class of K-sample test for comparing the cumulative incidence of competing risk. Ann Stat 1988, 16:1141-1154.
19. George J.N., Sadler J.E., Lämmle B. Platelets: thrombotic thrombocytopenic purpura. Hematology (Am Soc Hematol Educ Program) 2002, 315-334.
20. Tsai H.M. Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura. J Am Soc Nephrol 2003, 14:1072-1081.
21. Howard M.A., Williams L.A., Terrell D.R., et al. Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Transfusion 2006, 46:154-156.
22. Gutterman L.A., Kloster B., Tsai H.M. Rituximab therapy for refractory thrombotic thrombocytopenic purpura. Blood Cells Mol Dis 2002, 28:385-391.
23. Sadler J.E., Moake J.L., Miyata T., et al. Recent advances in thrombotic thrombocytopenic purpura. Hematology (Am Soc Hematol Educ Program) 2004, 407-423.
24. Shumak K.H., Rock G.A., Nair R.C. Late relapses in patients successfully treated for thrombotic thrombocytopenic purpura. Canadian Apheresis Group. Ann Intern Med 1995, 122:569-572.
25. Ziman A., Mitri M., Klapper E., et al. Combination vincristine and plasma exchange as initial therapy in patients with thrombotic thrombocytopenic purpura: one institution's experience and review of the literature. Transfusion 2005, 45:41-49.
26. Kremer Hovinga J.A., Studt J.D., Demarmels F., et al. Splenectomy in relapsing and plasma-refractory acquired thrombotic thrombocytopenic purpura. Haematologica 2004, 89:320-324.
27. Millward P.M., Bandarenko N., Chang P.P., et al. Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximab. Transfusion 2005, 45:1481-1486.