Effects of an antagonist of the gastrin-releasing peptide receptor in an animal model of uveitis

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 11, 2009, Pages 5300-5303

  Pereira, David Valter ^a   Steckert, Amanda Valnier ^a   Petronilho, Franciele Mina ^a   Petronilho, Fabricia ^a,b   Roesler, Rafael ^b,c   Schwartsmann, Gilberto ^c   Ritter, Cristiane ^a   Dal Pizzol, Felipe ^a,b  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GASTRIN RELEASING PEPTIDE RECEPTOR; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN; MYELOPEROXIDASE; RC 3095; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UVEITIS;

ANIMALS; ANTICARCINOGENIC AGENTS; AQUEOUS HUMOR; BOMBESIN; CHEMOKINE CCL2; DEXAMETHASONE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GASTRIN-RELEASING PEPTIDE; GLUCOCORTICOIDS; IRIS; LIPOPOLYSACCHARIDES; MALE; PEPTIDE FRAGMENTS; PEROXIDASE; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; RECEPTORS, BOMBESIN; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 78649415641     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3525     Document Type: Article

References (36)

1. Fernandes LC, Castro FM, Oréfice F. Epidemiologia das Uveítes. Rio de Janeiro: Cultura Médica; 2000:31-33.
2. Ooi KG, Galatowicz G, Calder VL, Lightman SL. Cytokines and chemokines in uveitis-is there a correlation with clinical phenotype? Clin Med Res. 2006;4:294-309.
3. Crane IJ, McKillop-Smith S, Wallace CA, Lamont GR, Forrester JV. Expression of the chemokines MIP-1alpha, MCP-1, and RANTES in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci.2001;42:1547-1552.
4. Wang LM, Kitteringham N, Mineshita S, et al. The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades- Behçet's disease. Arch Dermatol Res. 1997;298:444-447.
5. Mantas C, Direskeneli H, Oz D, Yavuz S, Akoglu T. IL-8 producing cells in patients with Behçet's disease. Clin Exp Rheumatol. 2000; 18:249-251.
6. Verma MJ, Lloyd A, Rager H, et al. Chemokines in acute anterior uveitis. Curr Eye Res. 1997;16:1202-1208.
7. Nussenblatt RB. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest Ophthalmol Vis Sci. 1991;32:3131-3141.
8. O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, Shanahan FJ. The role of substance P in inflammatory disease. Cell Physiol. 2004;201:167-180.
9. Keeble JE, Brain SD. A role for substance P in arthritis? Neurosci Lett. 2004;361:176-179.
10. Bedoui S, Miyake S, Straub RH, Von Horsten S, Yamamura T. More sympathy for autoimmunity with neuropeptide Y? Trends Immunol. 2004;25:508-512.
11. Moriyama M, Sato T, Inoue H, et al. The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J Exp Med. 2005;202:217-224.
12. Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT. Neuropeptides in experimental and degenerative arthritis. Ann NY Acad Sci. 2002;966:384-399.
13. Cuesta MC, Quintero L, Pons H, Suarez-Roca H. Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. Neurochem Int. 2002;40:301-306.
14. Delgado M, Pozo D, Ganea D. The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol Rev. 2004; 56:249-290.
15. Petronilho F, Roesler R, Schwartsmann G, Dal-Pizzol F. Gastrinreleasing peptide receptor as a molecular target for inflammatory diseases. Inflamm Allergy Drug Targets. 2007;6:197-200.
16. McKillop JM, Foy WL, Johnston CF, Shaw C, Murphy RF, Buchanan KD. Gastrin-releasing peptide (GRP) immunoreactivity in the rat retina: a radioimmunoassay, immunohistochemical and chromatographic study. Brain Res. 1988;447:239-245.
17. Dal-Pizzol F, Di Leone LP, Ritter C, et al. Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis. Am J Respir Crit Care Med. 2006;173:84-90.
18. De Young M, Kheifets JB, Ballaron SJ, Young JM. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions. 1989;26:335-341.
19. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186:421-431.
20. Levine RL, Garland D, Oliver CN, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990; 186:464-478.
21. Yadav UC, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2007;48:4634-4642.
22. Chi ZL, Hayasaka S, Zhang XY, Cui HS, Hayasaka Y. A cholinergic agonist attenuates endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2007;48:2719-2725.
23. Poulaki V, Iliaki E, Mitsiades N, et al. Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. FASEB J. 2007;21: 2113-2123.
24. Elgebaly SA, Miano D, Ehlers W, Rahhal F, Tyles E, El-Kerm AF. The induction of anterior chamber inflammation by factors released from hydrogen peroxide-injured corneas: effect of dexamethasone and indomethacin. J Ocul Pharmacol. 1994;10:295-306.
25. Salvemini D, Mazzon E, Dugo L, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. Br J Pharmacol. 2001;132:815-827.
26. Ito K, Herbert C, Siegle JS, et al. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Respir Cell Mol Biol. 2008;39:543-550.
27. Curnow SJ, Wloka K, Faint JM, et al. Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis. J Immunol. 2004;172:7154-7161.
28. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001;53:135-159.
29. Rocksen D, Lillehook B, Larsson R, Johansson T, Bucht A. Differential anti-inflammatory and anti-oxidative effects of dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000;122:249-256.
30. Zhang XY, Hayasaka S, Hayasaka Y, Cui HA, Chi ZL. Effect of N-acetylcysteine on lipopolysaccharide-induced uveitis in rats. Jpn J Ophthalmol. 2007;51:14-20.
31. Chi ZL, Hayasaka S, Zhang XY, Hayasaka Y, Cui HA. Effects of rolipram, a selective inhibitor of type 4 phosphodiesterase, on lipopolysaccharide-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2004;45:2497-2502.
32. Hellich MR, Ives KL, Udupi V, et al. Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion. J Biol Chem. 1999;274:23901-23909.
33. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37-40.
34. Levine L, Lucci JA, Pazdrak B, et al. Bombesin stimulates nuclear factor B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res. 2003;63:3495-3502.
35. Rosenbaum JT, Rosenzweig HL, Smith JR, Martin TM, Planck SR. Uveitis secondary to bacterial products. Ophthalmic Res. 2008;40: 165-168.
36. Kerr EC, Copland DA, Dick AD, Nicholson LB. The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis. Progr Retinal Eye Res. 2008;27:527-535.