Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

Chemistry and Biology

Volumn 17, Issue 11, 2010, Pages 1250-1255

  Dorfmueller, Helge C ^a   Borodkin, Vladimir S ^a   Schimpl, Marianne ^a   Zheng, Xiaowei ^a   Kime, Robert ^a   Read, Kevin D ^a   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; ENZYME INHIBITOR; HEXOSAMINIDASE C; N ACETYLGLUCOSAMINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETYLGLUCOSAMINE; AMINO ACID SUBSTITUTION; BETA-N-ACETYLHEXOSAMINIDASES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HEK293 CELLS; HEXOSAMINIDASES; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

METAZOA;

EID: 78649383623     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.09.014     Document Type: Article

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