Kernelized Z' factor in multiparametric screening technology

RNA Biology

Volumn 7, Issue 5, 2010, Pages 615-620

  Kozak, Karol ^a   Csucs, Gabor ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Assay quality; Bioinfromatics; High content screening; Pattern recognition; RNAi

Indexed keywords

ALGORITHM; ARTICLE; DATA ANALYSIS; GENE SILENCING; KERNEL METHOD; NONLINEAR SYSTEM; QUALITY CONTROL; RNA INTERFERENCE; STATISTICAL ANALYSIS;

ALGORITHMS; DATA MINING; EUKARYOTA; HUMANS; MULTIVARIATE ANALYSIS; RNA INTERFERENCE;

EID: 78649358119     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.7.5.13239     Document Type: Article

References (13)

1. Zhang JH, Chung TDY, Oldenburg K. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999; 4:67-73.
2. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391:806-11.
3. Hannon GJ. RNA: A Guide to Gene Silencing, Cold Spring Harbor Laboratory Press. New York 2003.
4. Kurreck J. RNA interference: perspectives and caveats. RNA Interference Gene Silencing 2005; 1:50-1.
5. Mahanthappa N. Translating RNA interference into therapies for human diseases. Pharmacogenomics 2005; 6:879-83.
6. Whelan J. First clinical data on RNAi. Drug Discovery Today 2005; 10:1014-5.
7. Nature News, Silent running: the race to the clinic. Nature 2006; 442:614-5.
8. Zuck P, Murray EM, Stec E, Grobler JA, Simon AJ, Strulovici B, et al. A cell-based β-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication. Anal Biochem 2004; 334:344-55.
9. MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005; 7:591-600.
10. Nybakken K, Vokes S, Lin TY, McMahon AP, Perrimon NA. Genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the HH signalling pathway. Nat Genet 2005; 37:1323-32.
11. Pelkmans L, Fava E, Grabner H, Hannus M, Habermann B, Krausz E, et al. Genome-wide analysis of human kinases in clathrinand caveolae/raft-mediated endocytosis. Nature 2005; 436:78-86.
12. Kümmel A, Gubler H, Gehin P, Beibel M, Gabriel D, Parker CN. Integration of Multiple Readouts into the Z' Factor for Assay Quality Assessment. J Biomol Screen 2010; 15:95.
13. Schoekopf B, Smola A. Learning with Kernels: Support Vector Machines, Regularization, Optimization and Beyond. MIT Press 2002.