Neuroprotection in acute ischemic stroke - current status

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 9, 2010, Pages 2200-2202

  Auriel, E ^a   Bornstein, N M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Ischemic penumbra; Neuroprotection; Stroke

Indexed keywords

NEUROPROTECTIVE AGENT;

ANIMAL; BRAIN ISCHEMIA; CELL DEATH; CELL PROTECTION; CLINICAL TRIAL (TOPIC); CYTOLOGY; DRUG EFFECT; HUMAN; NERVE CELL; PATHOLOGY; REVIEW; STROKE;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CLINICAL TRIALS AS TOPIC; CYTOPROTECTION; HUMANS; NEURONS; NEUROPROTECTIVE AGENTS; STROKE;

ANIMALIA;

EID: 78649353919     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01135.x     Document Type: Review

References (24)

1. Auriel E. Anatomy and physiology of stroke. In: Bornstein NM, editor. Stroke practical guide for clinicians. Basel: Karger; 2009, pp. 1-7.
2. Mies G, Iijima T, Hossmann K-A. Correlation between peri-infarct DC shifts and ischemic neuronal damage in cerebral cortex of rat. Neurorep. 1993; 4: 709-711.
3. Maiese K. The dynamics of cellular injury: transformation intoeuronal and vascular protection. Histol Histopathol. 2001; 16: 633-44.
4. Brown RH, Ropper AH. Adams and Victor's principles of neurology. 8th ed. In: Cerebrovascular diseases. New York: McGraw-Hill; 2005. p. 660-747.
5. Small DL, Morley P, Buchan AM. Biology of ischemic cerebral cell death. Prog Cardiovasc Dis. 1999; 42: 185-207.
6. Shuaib A, Hussain MS. The past and future of neuroprotection in cerebral ischaemic stroke. Eur Neurol. 2008; 59: 4-14.
7. O'Collins VE, Macleod MR, Donnan GA, et al. 1,026 experimental treatments in acute stroke. Ann Neurol. 2006; 59: 467-77.
8. Wahlgren NG, Ahmed N. Neuroprotection in cerebral ischaemia: facts and fancies-the need for new approaches. Cerebrovasc Dis. 2004; 17: 153-66.
9. Foster AC, Gill R, Woodruff GN. Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation. J Neurosci. 1988; 8: 4745-54.
10. Gladstone DJ, Black SE, Hakim AM. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke. 2002; 33: 2123-36.
11. Röther J. Neuroprotection does not work. Stroke. 2008; 39: 523-34.
12. Marler JR, Tilley BC, Lu M, et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. Neurology. 2000; 55: 1649-55.
13. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359: 1317-29.
14. Saver JL. Time is brain: quantified. Stroke. 2006; 37: 263-6.
15. Muir KW, Grosset DG. Neuroprotection for acute stroke: making clinical trials work. Stroke. 1999; 30: 180-2.
16. Baird AE, Warach S. Using pathophysiology in acute stroke trial. Stroke. 1999; 30: 1293.
17. Muir KW. Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design. Stroke. 2002; 33: 1545-50.
18. Auriel E, Bornstein NM. Management of acute ischemic stroke - the HYPER-link - hypertension, hyperglycemia and hyperthermia. In: Bornstein NM, editor. Stroke practical guide for clinicians. Basel: Karger; 2009, pp. 1-7.
19. Dewar D, Yam P, McCulloch J. Drug development for stroke: importance of protecting cerebral white matter. Eur J Pharmacol. 1999; 375: 41-50.
20. Samsa GP, Matchar DB. Have randomized controlled trials of neuroprotective drugs been underpowered? An illustration of three statistical principles. Stroke. 2001; 32: 669-74.
21. Donnan GA, Davis SM. Neuroprotection: still achievable in humans. Stroke. 2008; 39: 525.
22. Yeung PK. DP-b99 (D-Pharm). Curr Opin Investig Drugs. 2004; 5: 90-4.
23. Hong Z, Moessler H, Bornstein N, et al. A double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin in patients with acute ischaemic stroke in Asia - CASTA. Int J Stroke. 2009; 4: 406-12.
24. Muresanu DF. Management of acute stroke: neuroprotection. In: Bornstein NM, editor. Stroke practical guide for clinicians. Basel: Karger; 2009, pp. 1-7.