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Volumn 5, Issue 3, 2010, Pages 141-147

Personalized medicine in oncology: A personal view with myths and facts

Author keywords

Antibodies; Resistance; Side effects; Small molecules; Targeted therapy

Indexed keywords

BUSULFAN; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DASATINIB; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IMATINIB; IRINOTECAN; LAPATINIB; MERCAPTOPURINE; METHOTREXATE; OLAPARIB; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PERTUZUMAB; PLX 4032; RITUXIMAB; SORAFENIB; SUNITINIB; TAMOXIFEN; TAMOXIFEN CITRATE; TEMSIROLIMUS; TRASTUZUMAB; UNINDEXED DRUG;

EID: 78649351681     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488410791498789     Document Type: Article
Times cited : (7)

References (47)
  • 1
    • 0036024583 scopus 로고    scopus 로고
    • Dosing strategies for anticancer drugs: The good, the bad and the body surface area
    • Felici A, Verweij J, Sparreboom A. Dosing strategies for anticancer drugs: the good, the bad and the body surface area. Eur J Cancer 2002; 38: 1677-84
    • (2002) Eur J Cancer , vol.38 , pp. 1677-1684
    • Felici, A.1    Verweij, J.2    Sparreboom, A.3
  • 2
    • 0037464769 scopus 로고    scopus 로고
    • Overview of the main out-comes in breast-cancer prevention trials
    • Cuzick J, Powles T, Veronesi U, et al. Overview of the main out-comes in breast-cancer prevention trials. Lancet 2003; 361: 296-300
    • (2003) Lancet , vol.361 , pp. 296-300
    • Cuzick, J.1    Powles, T.2    Veronesi, U.3
  • 3
    • 52049098991 scopus 로고    scopus 로고
    • Targeted therapies in breast cancer: Estab-lished drugs and recent developments
    • Fischgräbe J, Wlfing P. Targeted therapies in breast cancer: estabished drugs and recent developments. Curr Clin Pharmacol 2008;3: 85-98
    • (2008) Curr Clin Pharmacol , vol.3 , pp. 85-98
    • Fischgräbe, J.1    Wlfing, P.2
  • 4
    • 75749097259 scopus 로고    scopus 로고
    • Targeted therapies for non-small cell lung cancer
    • Dempke WC, Suto T, Reck M. Targeted therapies for non-small cell lung cancer. Lung Cancer 2010; 67: 257-74
    • (2010) Lung Cancer , vol.67 , pp. 257-274
    • Dempke, W.C.1    Suto, T.2    Reck, M.3
  • 6
  • 7
    • 77649162823 scopus 로고    scopus 로고
    • Why doesn't imatinib cure chronic myeloid leukemia?
    • Redner RL. Why doesn't imatinib cure chronic myeloid leukemia? Oncologist 2010; 15(2): 182-6
    • (2010) Oncologist , vol.15 , Issue.2 , pp. 182-186
    • Redner, R.L.1
  • 8
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355: 2408-17
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 9
    • 43449118108 scopus 로고    scopus 로고
    • Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5 year outcome
    • Palandri F, Iacobucci I, Castagnetti F, et al. Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5 year outcome. Haematologica 2008; 93: 770-4
    • (2008) Haematologica , vol.93 , pp. 770-774
    • Palandri, F.1    Iacobucci, I.2    Castagnetti, F.3
  • 10
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353: 1659-72
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 12
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497
    • (2004) Science , vol.304 , pp. 1497
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 14
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer-molecular and clinical predictors of outcome
    • Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer-molecular and clinical predictors of outcome. N Engl J Med 2005; 353: 133-44
    • (2005) N Engl J Med , vol.353 , pp. 133-144
    • Tsao, M.S.1    Sakurada, A.2    Cutz, J.C.3
  • 15
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009; 361: 958-67
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 16
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor anderlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor anderlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-39
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 17
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005; 366: 1527-37
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 18
    • 33750962024 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
    • Hirsch FR, Varella-Garcia M, Bunn PA, et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol 2006; 24: 5034-42
    • (2006) J Clin Oncol , vol.24 , pp. 5034-5042
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3
  • 19
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • Kim ES, Hirsh V, Mok T, et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 2008; 372: 1809-18
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3
  • 20
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-34
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 21
    • 65349189958 scopus 로고    scopus 로고
    • American society of clinical oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to antiepidermal growth factor receptor monoclonal antibody therapy
    • Allegra CJ, Jessup JM, Somerfield MR, et al. American society of clinical oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to antiepidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 2009; 27: 2091-6
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 22
    • 77149176249 scopus 로고    scopus 로고
    • KRAS mutation screening in colorectal cancer: From paper to practice
    • Fakih MM. KRAS mutation screening in colorectal cancer: From paper to practice. Clin Colorectal Cancer 2010; 9: 22-30
    • (2010) Clin Colorectal Cancer , vol.9 , pp. 22-30
    • Fakih, M.M.1
  • 23
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008; 26: 5705-12
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 24
    • 70649098325 scopus 로고    scopus 로고
    • Evolving novel anti-HER2 strategies
    • Jones KL, Buzdar AU. Evolving novel anti-HER2 strategies. Lancet Oncol 2009; 10: 1179-87
    • (2009) Lancet Oncol , vol.10 , pp. 1179-1187
    • Jones, K.L.1    Buzdar, A.U.2
  • 25
    • 35448967331 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib in chronic myeloid leukemia. Part I
    • Apperley JF. Mechanisms of resistance to imatinib in chronic myeloid leukemia. Part I. Lancet Oncol 2007; 8: 1018-29
    • (2007) Lancet Oncol , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 26
    • 36549088120 scopus 로고    scopus 로고
    • Management of resistance to imatinib in chronic myeloid leukemia. Part II
    • Apperley JF. Management of resistance to imatinib in chronic myeloid leukemia. Part II. Lancet Oncol 2007; 8: 1116-28
    • (2007) Lancet Oncol , vol.8 , pp. 1116-1128
    • Apperley, J.F.1
  • 27
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 28
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosomepositive leukemias. N Engl J Med 2006; 354: 2531-41
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 29
    • 34247480545 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
    • Force T, Krause DS, Van Etten RA. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 2007; 7: 332-44
    • (2007) Nat Rev Cancer , vol.7 , pp. 332-344
    • Force, T.1    Krause, D.S.2    van Etten, R.A.3
  • 30
    • 21344462378 scopus 로고    scopus 로고
    • Cutaneous side-effects of kinase inhibitors and blocking antibodies
    • Robert C, Soria JC, Spatz A, et al. Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol 2005; 6: 491-500
    • (2005) Lancet Oncol , vol.6 , pp. 491-500
    • Robert, C.1    Soria, J.C.2    Spatz, A.3
  • 31
    • 75649145389 scopus 로고    scopus 로고
    • Combining targeted therapies: Practical issues to consider at the bench and bedside
    • Rodon J, Perez J, Kurzrock R. Combining targeted therapies: practical issues to consider at the bench and bedside. Oncologist 2010; 15: 37-50
    • (2010) Oncologist , vol.15 , pp. 37-50
    • Rodon, J.1    Perez, J.2    Kurzrock, R.3
  • 33
    • 33845753369 scopus 로고    scopus 로고
    • Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients
    • Booth BP, Rahman A, Dagher R, et al. Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients. J Clin Pharmacol 2007; 47: 101-11
    • (2007) J Clin Pharmacol , vol.47 , pp. 101-111
    • Booth, B.P.1    Rahman, A.2    Dagher, R.3
  • 34
    • 0015987706 scopus 로고
    • Adriamycin chemotherapy: Efficacy, safety, and pharmacologic basis of an intermittent single high-dose schedule
    • Benjamin RS, Wiernik PH, Bachur NR. Adriamycin chemotherapy: efficacy, safety, and pharmacologic basis of an intermittent single high-dose schedule. Cancer 1974; 33: 19-27
    • (1974) Cancer , vol.33 , pp. 19-27
    • Benjamin, R.S.1    Wiernik, P.H.2    Bachur, N.R.3
  • 35
    • 35248899867 scopus 로고    scopus 로고
    • Safety and pharmacology of paclitaxel in patients with impaired liver function: A population pharmacokinetic-pharmacodynamic study
    • Joerger M, Huitema ADR, Huizing MT, et al. Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study. Br J Clin Pharmacol 2007; 64: 622-33
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 622-633
    • Joerger, M.1    Huitema, A.D.R.2    Huizing, M.T.3
  • 37
    • 78649307699 scopus 로고    scopus 로고
    • Pharmacogenetics of irinotecan disposition and toxicity: A review
    • [Epub ahead of print]
    • Fujita K-I, Sparreboom A. Pharmacogenetics of irinotecan disposition and toxicity: a review. Curr Clin Pharmacol 2010; 5 [Epub ahead of print]
    • (2010) Curr Clin Pharmacol , vol.5
    • Fujita, K.-I.1    Sparreboom, A.2
  • 38
    • 84934436050 scopus 로고    scopus 로고
    • Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy
    • Bosch TM. Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy. Methods Mol Biol 2008; 448: 63-76
    • (2008) Methods Mol Biol , vol.448 , pp. 63-76
    • Bosch, T.M.1
  • 39
    • 0024440650 scopus 로고
    • Carboplatin dosage: Prospective evaluation of a simple formula based on renal function
    • Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989; 7: 1748-56
    • (1989) J Clin Oncol , vol.7 , pp. 1748-1756
    • Calvert, A.H.1    Newell, D.R.2    Gumbrell, L.A.3
  • 40
    • 33845440648 scopus 로고    scopus 로고
    • Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia
    • Aumente D, Buelga DS, Lukas JC, Gomez P, Torres A, Garcia MJ. Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia. Clin Pharmacokinet 2006; 45: 1227-38
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1227-1238
    • Aumente, D.1    Buelga, D.S.2    Lukas, J.C.3    Gomez, P.4    Torres, A.5    Garcia, M.J.6
  • 42
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010: 28: 1138-44.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 43
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 235-42
    • (2002) N Engl J Med , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 44
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Köhne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-17
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 45
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-43
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 46
    • 72949090154 scopus 로고    scopus 로고
    • Cancer research. Melanoma drug vindicates targeted approach
    • Garber K. Cancer research. Melanoma drug vindicates targeted approach. Science 2009; 326: 1619
    • (2009) Science , vol.326 , pp. 1619
    • Garber, K.1
  • 47
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-Ribose) polymerase in tumors from BCRA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-Ribose) polymerase in tumors from BCRA mutation carriers. N Engl J Med 2009; 361: 123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3


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