The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms

Immunology and Allergy Clinics of North America

Volumn 31, Issue 1, 2011, Pages 81-93

  Gouin, Jean Philippe ^a,b   Kiecolt Glaser, Janice K ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Cortisol; Cytokine; Oxytocin; Psychoneuroimmunology; Stress; Wound healing

Indexed keywords

CATECHOLAMINE; CYTOKINE; FLUOXETINE; GLUCOCORTICOID; MATRIX METALLOPROTEINASE; OXYTOCIN; VASOPRESSIN;

AEROBIC EXERCISE; ANXIETY DISORDER; BLISTER; CATECHOLAMINE SYNTHESIS; CORTICOSTEROID METABOLISM; CYTOKINE PRODUCTION; ENZYME BLOOD LEVEL; EXPERIMENTAL STUDY; HUMAN; HYPOXIA; INFECTION SENSITIVITY; INTERVENTION STUDY; MENTAL STRESS; MOOD DISORDER; NONHUMAN; OBSERVATIONAL STUDY; PHYSICAL STRESS; PRIORITY JOURNAL; PUNCH BIOPSY; REVIEW; SKIN DEFECT; SOCIAL STRESS; STRESS MANAGEMENT; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANIMALS; CYTOKINES; DISEASE SUSCEPTIBILITY; HUMANS; INFECTION; INFLAMMATION; PAIN; PSYCHONEUROIMMUNOLOGY; STRESS, PSYCHOLOGICAL; WOUND HEALING;

EID: 78649340217     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.iac.2010.09.010     Document Type: Review

References (66)

1. Walburn J., Vedhara K., Hankins M., et al. Psychological stress and wound healing in humans: a systematic review and meta-analysis. J Psychosom Res 2009, 67(3):253-271.
2. Kiecolt-Glaser J.K., Page G.G., Marucha P.T., et al. Psychological influences on surgical recovery: perspectives from psychoneuroimmunology. Am Psychol 1998, 53:1209-1218.
3. Rosenberger P.H., Jokl P., Ickovics J. Psychosocial factors and surgical outcomes: an evidence-based literature review. J Am Acad Orthop Surg 2006, 14(7):397-405.
4. Boeke S., Duivenvoorden H.J., Verhage F., et al. Prediction of postoperative pain and duration of hospitalization using two anxiety measures. Pain 1991, 45(3):293-297.
5. Scheier M.F., Matthews K.A., Owens J.F., et al. Optimism and rehospitalization after coronary artery bypass graft surgery. Arch Intern Med 1999, 159:829-835.
6. Doering L.V., Moser D.K., Lemankiewicz W., et al. Depression, healing, and recovery from coronary artery bypass surgery. Am J Crit Care 2005, 14(4):316-324.
7. Cole-King A., Harding K.G. Psychological factors and delayed healing in chronic wounds. Psychosom Med 2001, 63:216-220.
8. Gouin J.P., Hantsoo L., Kiecolt-Glaser J.K. Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation 2008, 15(4-6):251-259.
9. Kiecolt-Glaser J.K., Marucha P.T., Malarkey W.B., et al. Slowing of wound healing by psychological stress. Lancet 1995, 346:1194-1196.
10. Ebrecht M., Hextall J., Kirtley L.G., et al. Perceived stress and cortisol levels predict speed of wound heating in healthy male adults. Psychoneuroendocrinology 2004, 29(6):798-809.
11. McGuire L., Heffner K., Glaser R., et al. Pain and wound healing in surgical patients. Ann Behav Med 2006, 31(2):165-172.
12. Graham J.E., Robles T.F., Kiecolt-Glaser J.K., et al. Hostility and pain are related to inflammation in older adults. Brain Behav Immun 2006, 20(4):389-400.
13. Padgett D.A., Marucha P.T., Sheridan J.F. Restraint stress slows cutaneous wound healing in mice. Brain Behav Immun 1998, 12:64-73.
14. French S.S., Matt K.S., Moore M.C. The effects of stress on wound healing in male tree lizards (Urosaurus ornatus). Gen Comp Endocrinol 2006, 145(2):128-132.
15. Martin L.B., Glasper E.R., Nelson R.J., et al. Prolonged separation delays wound healing in monogamous California mice, Peromyscus californicus, but not in polygynous white-footed mice, P. leucopus. Physiol Behav 2006, 87(5):837-841.
16. Marucha P.T., Kiecolt-Glaser J.K., Favagehi M. Mucosal wound healing is impaired by examination stress. Psychosom Med 1998, 60:362-365.
17. Bosch J.A., Engeland C.G., Cacioppo J.T., et al. Depressive symptoms predict mucosal wound healing. Psychosom Med 2007, 69(7):597-605.
18. Kiecolt-Glaser J.K., Loving T.J., Stowell J.R., et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry 2005, 62:1377-1384.
19. Gouin J.P., Carter C.S., Pournajafi-Nazarloo H., et al. Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 2010, 35(7):1082-1090.
20. Gouin J.P., Kiecolt-Glaser J.K., Malarkey W.B., et al. The influence of anger expression on wound healing. Brain Behav Immun 2008, 22(5):699-708.
21. Altemus M., Rao B., Dhabhar F.S., et al. Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol 2001, 117:309-317.
22. Dickerson S.S., Kemeny M.E. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 2004, 130(3):355-391.
23. Kirschbaum C., Pirke K.M., Hellhammer D.H. The " Trier social stress test" -a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81.
24. Robles T.F. Stress, social support, and delayed skin barrier recovery. Psychosom Med 2007, 69(8):807-815.
25. Robles T.F., Brooks K.P., Pressman S.D. Trait positive affect buffers the effects of acute stress on skin barrier recovery. Health Psychol 2009, 28(3):373-378.
26. Garg A., Chren M.M., Sands L.P., et al. Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol 2000, 137:53-59.
27. Muizzuddin N., Matsui M.S., Marenus K.D., et al. Impact of stress of marital dissolution on skin barrier recovery: tape stripping and measurement of trans-epidermal water loss (TEWL). Skin Res Technol 2003, 9:34-38.
28. Denda M., Tsuchiya T., Hosoi J., et al. Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin. Br J Dermatol 1998, 138:780-785.
29. Denda M., Tsuchiya T., Elias P.M., et al. Stress alters cutaneous permeability barrier homeostasis. Am J Physiol Regul Integr Comp Physiol 2000, 278:R367-R372.
30. Johnston M., Vogele C. Benefits of psychological preparation for surgery: a meta-analysis. Ann Behav Med 1993, 15:245-256.
31. Montgomery G.H., David D., Winkel G., et al. The effectiveness of adjunctive hypnosis with surgical patients: a meta-analysis. Anesth Analg 2002, 94(6):1639-1645. [table of contents].
32. Esterling B.A., L'Abate L., Murray E.J., et al. Empirical foundations for writing in prevention and psychotherapy: mental and physical health outcomes. Clin Psychol Rev 1999, 19(1):79-96.
33. Weinman J., Ebrecht M., Scott S., et al. Enhanced wound healing after emotional disclosure intervention. Br J Health Psychol 2008, 13(Pt 1):95-102.
34. Emery C.F., Blumenthal J.A. Effects of physical exercise on psychological and cognitive functioning of older adults. Ann Behav Med 1991, 13:99-107.
35. Emery C.F., Kiecolt-Glaser J.K., Glaser R., et al. Exercise accelerates wound healing among healthy older adults: a preliminary investigation. J Gerontol A Biol Sci Med Sci 2005, 60(11):1432-1436.
36. Keylock K.T., Vieira V.J., Wallig M.A., et al. Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol Regul Integr Comp Physiol 2008, 294(1):R179-R184.
37. House J.S., Landis K.R., Umberson D. Social relationships and health. Science 1988, 241:540-545.
38. Glasper E.R., Devries A.C. Social structure influences effects of pair-housing on wound healing. Brain Behav Immun 2005, 19(1):61-68.
39. Detillion C.E., Craft T.K., Glasper E.R., et al. Social facilitation of wound healing. Psychoneuroendocrinology 2004, 29(8):1004-1011.
40. Rossi A., Barraco A., Donda P. Fluoxetine: a review on evidence based medicine. Ann Gen Hosp Psychiatry 2004, 3(1):2.
41. Farahani R.M., Sadr K., Rad J.S., et al. Fluoxetine enhances cutaneous wound healing in chronically stressed Wistar rats. Adv Skin Wound Care 2007, 20(3):157-165.
42. Hubner G., Brauchle M., Smola H., et al. Differential regulation of pro-inflammatory cytokines during wound healing in normal glucocorticoid-treated mice. Cytokine 1996, 8(7):548-556.
43. Werner S., Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003, 83(3):835-870.
44. Gallucci R.M., Simeonova P.P., Matheson J.M., et al. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J 2000, 14:2525-2531.
45. Padgett D.A., Glaser R. How stress influences the immune response. Trends Immunol 2003, 24(8):444-448.
46. Glaser R., Kiecolt-Glaser J.K. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005, 5:243-251.
47. Eijkelkamp N., Engeland C.G., Gajendrareddy P.K., et al. Restraint stress impairs early wound healing in mice via alpha-adrenergic but not beta-adrenergic receptors. Brain Behav Immun 2007, 21(4):409-412.
48. Romana-Souza B., Otranto M., Vieira A.M., et al. Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice. Brain Behav Immun 2010, 24(3):427-437.
49. Sivamani R.K., Pullar C.E., Manabat-Hidalgo C.G., et al. Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers. PLoS Med 2009, 6(1):e12.
50. Vitalo A., Fricchione J., Casali M., et al. Nest making and oxytocin comparably promote wound healing in isolation reared rats. PLoS One 2009, 4(5):e5523.
51. Glaser R., Kiecolt-Glaser J.K., Marucha P.T., et al. Stress-related changes in proinflammatory cytokine production in wounds. Arch Gen Psychiatry 1999, 56:450-456.
52. Broadbent E., Petrie K.J., Alley P.G., et al. Psychological stress impairs early wound repair following surgery. Psychosom Med 2003, 65(5):865-869.
53. Mercado A.M., Padgett D.A., Sheridan J.F., et al. Altered kinetics of IL-1 alpha, IL-1 beta, and KGF-1 gene expression in early wounds of restrained mice. Brain Behav Immun 2002, 16(2):150-162.
54. Head C.C., Farrow M.J., Sheridan J.F., et al. Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. Brain Behav Immun 2006, 20(6):590-596.
55. Yang E.V., Bane C.M., MacCallum R.C., et al. Stress-related modulation of matrix metalloproteinase expression. J Neuroimmunol 2002, 133(1-2):144-150.
56. Rojas I., Padgett D.A., Sheridan J.F., et al. Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain Behav Immun 2002, 16:74-84.
57. Aberg K.M., Radek K.A., Choi E.H., et al. Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 2007, 117(11):3339-3349.
58. Gajendrareddy P.K., Sen C.K., Horan M.P., et al. Hyperbaric oxygen therapy ameliorates stress-impaired dermal wound healing. Brain Behav Immun 2005, 19(3):217-222.
59. Steptoe A., Wardle J., Pollard T.M., et al. Stress, social support and health-related behavior: a study of smoking, alcohol consumption and physical exercise. J Psychosom Res 1996, 41:171-180.
60. Vitaliano P.P., Scanlan J.M., Zhang J., et al. A path model of chronic stress, the metabolic syndrome, and coronary heart disease. Psychosom Med 2002, 64:418-435.
61. Benveniste K., Thut P. The effect of chronic alcoholism on wound healing. Proc Soc Exp Biol Med 1981, 166:568-575.
62. Silverstein P. Smoking and wound healing. Am J Med 1992, 93:22S-24S.
63. Veldhuis J.D., Iranmanesch A. Physiological regulation of the human growth hormone (GH)-insulin-like growth factor type I (IGF-I) axis: predominant impact of age, obesity, gonadal function, and sleep. Sleep 1996, 19:S221-S224.
64. Russell L. The importance of patients' nutritional status in wound healing. Br J Nurs 2001, 10(6 Suppl):S42. S44-9.
65. Posthauer M.E. The role of nutrition in wound care. Adv Skin Wound Care 2006, 19(1):43-52. [quiz: 53-4].
66. McDaniel J.C., Belury M., Ahijevych K., et al. Omega-3 fatty acids effect on wound healing. Wound Repair Regen 2008, 16(3):337-345.