Synthesis and optimization of antitubercular activities in a series of 4-(aryloxy)phenyl cyclopropyl methanols

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5965-5978

  Bisht, Surendra S ^a   Dwivedi, Namrata ^a   Chaturvedi, Vinita ^a   Anand, Namrata ^a   Misra, Mridul ^a   Sharma, Rahul ^a   Kumar, Brijesh ^a   Dwivedi, Richa ^a   Singh, Shyam ^a   Sinha, Sudhir Kumar ^a   Gupta, Versha ^b   Mishra, P R ^b   Dwivedi, Anil K ^b   Tripathi, Rama P ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

(Aryloxy)phenyl cyclopropyl methanol; (Aryloxy)phenyl cyclopropyl methanone; Antitubercular agents; Cytotoxicty; Mycobacterium tuberculosis; Sodium hydride

Indexed keywords

3 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYLMETHANOL; 4 (2 MORPHOLINOETHOXY)PHENYLMETHANOL; 4 [2 (DIISOPROPYLAMINO)ETHOXY]PHENYLMETHANOL; 4 [2 (DIMETHYLAMINO)ETHOXY]PHENYLMETHANOL; 4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYLMETHANOL; [4 (3 BROMOBENZYLOXY)PHENYL](CYCLOPROPYL)METHANOL; [4 (3 BROMOBENZYLOXY)PHENYL](CYCLOPROPYL)METHANONE; [4 (4 BROMOBENZYLOXY)PHENYL](CYCLOPROPYL)METHANOL; [4 (4 BROMOBENZYLOXY)PHENYL](CYCLOPROPYL)METHANONE; [4 [2 (N,N DIBUTYLAMINO)ETHOXY]PHENYL]CYCLOPROPYLMETHANONE; [4 [4 (BENZYLOXY)BENZYLOXY]PHENYL](CYCLOPROPYL)METHANONE; CYCLOPROPYL[4 (3 NITROBENZYLOXY)PHENYL]METHANOL; CYCLOPROPYL[4 (3 NITROBENZYLOXY)PHENYL]METHANONE; CYCLOPROPYL[4 (3,4,5 TRIMETHOXYBENZYLOXY)PHENYL]METHANOL; CYCLOPROPYL[4 (3,4,5 TRIMETHOXYBENZYLOXY)PHENYL]METHANONE; CYCLOPROPYL[4 [3 (2 PIPERIDIN 1 YLETHOXY)BENZYLOXY]PHENYL]METHANOL; CYCLOPROPYL[4 [3 (3,4 DICHLOROBENZYLOXY)BENZYLOXY]PHENYL]METHANOL; CYCLOPROPYL[4 [3 (3,4 DICHLOROBENZYLOXY)BENZYLOXY]PHENYL]METHANONE; CYCLOPROPYL[4 [4 (2 (DIMETHYLAMINO)ETHOXOY]BENZYLOXY]PHENYLMETHANONE; CYCLOPROPYL[4 [4 (2 DIISOPROPYLAMINO)ETHOXY]BENZYLOXY]PHENYLMETHANONE; CYCLOPROPYL[4 [4 (2 MORPHOLIN 4 YLETHOXY)BENZYLOXY]PHENYL]METHANOL; CYCLOPROPYL[4 [4 (2 MORPHOLIN 4 YLETHOXY)BENZYLOXY]PHENYL]METHANONE; CYCLOPROPYL[4 [4 (2 PIPERIDIN 1 YLETHOXY)BENZYLOXY]PHENYL]METHANONE; CYCLOPROPYL[4 [4 (PYRIDIN 2 YLMETHOXY)BENZYLOXY]PHENYL]METHANOL; CYCLOPROPYL[4 [4 [2 (DIMETHYLAMINO)ETHOXY]BENZYLOXY]PHENYL]METHANOL; ISONIAZID; METHANOL DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; FEMALE; MACROPHAGES; METHANOL; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 78649328348     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.063     Document Type: Article

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