Synthesis and antitumor activity of novel benzimidazole-5-carboxylic acid derivatives and their transition metal complexes as topoisomerease II inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5685-5691

  Galal, Shadia A ^a   Hegab, Khaled H ^a   Hashem, Ahmed M ^a   Youssef, Nabil S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antitumor activity; Benzimidazoles; Benzimidazolyl methyl pyridinium salts; Growth inhibitory activity; Topoisomerase II inhibitory activity; Transition metals complexes

Indexed keywords

1 (5 CARBOXY 1H BENZ[D]IMIDAZOL 2 YLMETHYL)PYRIDINIUM CHLORIDE; 1 (6 CARBOXY 1H BENZ[D]IMIDAZOL 2 YLMETHYL)PYRIDINIUM CHLORIDE; 1 [(5 CARBOXY 1H BENZO[D]IMIDAZOL 2 YL)METHYL] PYRIDINIUM COPPER(II) CHLORIDE; 1 [(6 CARBOXY 1H BENZO[D]IMIDAZOL 2 YL)METHYL] PYRIDINIUM COPPER(II) CHLORIDE; 2 (CHLOROMETHYL) 1H BENZ[D]IMIDAZOLE 5 CARBOXYLIC ACID; 2 (CHLOROMETHYL) 1H BENZ[D]IMIDAZOLE 6 CARBOXYLIC ACID; 2 (THIAZOL 2 YL)AMINOMETHYL 1H BENZ[D]IMIDAZOLE 5 CARBOXYLIC ACID; 2 (THIAZOL 2 YL)AMINOMETHYL 1H BENZ[D]IMIDAZOLE 6 CARBOXYLIC ACID; 2 [(1H BENZ[D]IMIDAZOL 2 YLAMINO)METHYL] 1H BENZO[D]IMIDAZOLE 5 CARBOXYLIC ACID; 2 [(1H BENZ[D]IMIDAZOL 2 YLAMINO)METHYL] 1H BENZO[D]IMIDAZOLE 6 CARBOXYLIC ACID; 2 [(PYRIDIN 2 YL)AMINOMETHYL] 1H BENZ[D]IMIDAZOLE 5 CARBOXYLIC ACID; 2 [(PYRIDIN 2 YL)AMINOMETHYL] 1H BENZ[D]IMIDAZOLE 6 CARBOXYLIC ACID; 2 [(PYRIDIN 4 YL)AMINOMETHYL] 1H BENZ[D]IMIDAZOLE 5 CARBOXYLIC ACID; 2 [(PYRIDIN 4 YL)AMINOMETHYL] 1H BENZ[D]IMIDAZOLE 6 CARBOXYLIC ACID; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; [2 (PYRIDINIUM 1 YLMETHYL) 1H BENZ[D]IMIDAZOLE 5 CARBONYLOXY]COBALT(II) COBALT(II) CHLORIDE; [2 (PYRIDINIUM 1 YLMETHYL) 1H BENZO[D]IMIDAZOLE 6 CARBONYLOXY]ZINC(II) CHLORIDE; CARBOXYLIC ACID DERIVATIVE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CARBOXYLIC ACIDS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MICE; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649319294     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.023     Document Type: Article

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