Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes

Ophthalmic Genetics

Volumn 31, Issue 4, 2010, Pages 215-220

  Khalilzadeh, Omid ^a,b   Anvari, Mehdi ^a,b   Esteghamati, Alireza ^a   Momen Heravi, Fatemeh ^b   Rashidi, Armin ^a   Amiri, Hoda Mojazi ^b   Tahvildari, Maryam ^b   Mahmoudi, Mahdi ^b,c   Amirzargar, Aliakbar ^b,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

graves' ophthalmopathy; IL 4; polymorphism; TGF ; IL 10

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DNA DETERMINATION; ENDOCRINE OPHTHALMOPATHY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; INFLAMMATION; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GRAVES OPHTHALMOPATHY; HUMANS; INTERLEUKIN-10; INTERLEUKIN-4; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 78649307747     PISSN: 13816810     EISSN: 17445094     Source Type: Journal    
DOI: 10.3109/13816810.2010.515648     Document Type: Article

References (20)

1. Weetman AP. Graves' disease. N Engl J Med 2000;343: 1236-1248.
2. Bednarczuk T, Gopinath B, Ploski R, et al. Susceptibility genes in Graves' ophthalmopathy: searching for a needle in a haystack? Clin Endocrinol (Oxf) 2007;67:3-19.
3. Wakelkamp IMBO, Baldeschi L, Wiersinga WM, et al. TSH-R expression and cytokine profle in orbital tissue of active vs. inactive Graves' ophthalmopathy patients. Clin Endocrinol (Oxf) 2003;58:280-287.
4. Heufelder AE, Joba W. Thyroid-associated eye disease. Strabismus 2000;8:101-111.
5. Hiromatsu Y, Yang D, Bednarczuk T, et al. Cytokine pro-fles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 2000;85:1194-1199.
6. Yamada H, Watanabe M, Nanba T, et al. The +869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. Clin Exp Immunol 2008;151:379-382.
7. Hobbs K, Negri J, Klinnert M, et al. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 1998;158:1958-1962.
8. Kumar S, Bahn RS. Relative overexpression of macrophage-derived cytokines in orbital adipose tissue from patients with graves' ophthalmopathy. J Clin Endocrinol Metab 2003;88:4246-4250.
9. Khalilzadeh O, Anvari M, Momen-Heravi F, et al. Gene polymorphisms of interleukin 4, interleukin 10 and transforming growth factor-beta in Graves' disease. Clin Exp Med 2010 June; 10(2): 123-128.
10. Werner SC. Modifcation of the classifcation of the eye changes of Graves' disease: recommendations of the Ad Hoc Committee of the American Thyroid Association. J Clin Endocrinol Metab 1977;44:203-204.
11. Khalilzadeh O, Anvari M, Esteghamati A, et al. Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and inter-leukin-1 receptor antagonist. Clin Experiment Ophthalmol 2009;37:614-619.
12. Anvari M, Khalilzadeh O, Esteghamati A, et al. Genetic susceptibility to Graves' ophthalmopathy: the role of polymorphisms in proinfammatory cytokine genes. Eye (Lond). 2010 June; 24(6): 1058-1063.
13. Kelso A. Cytokines: principles and prospects. Immunol Cell Biol 1998;76:300-317.
14. Romagnani S. Th1 and Th2 in human diseases. Clin Immunol Immunopathol 1996;80:225-235.
15. Mysliwiec JKA, Szelachowska M, Mikita A, et al. Serum pro-and anti-infammatory cytokines in patients with Graves' disease with ophthalmopathy during treatment with glucocorticoids. Rocz Akad Med Bialymst 1999;44:160-169.
16. Shiau MY, Huang CN, Yang TP, et al. Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease. Clin Biochem 2007;40:213-217.
17. Beebe AM, de Waal, CD, Malefyt R The role of interleu-kin-10 in autoimmune disease: systemic lupus erythema-tosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev 2002;13:403-412.
18. Awad MR, El-Gamel A, Hasleton P, et al. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fbrotic lung disease, and graft fbrosis after lung transplantation. Transplantation 1998;66:1014-1020.
19. Ochsner SGZ, Binswanger U, Knofach A. TGF-beta 1 gene expression in stable renal transplant recipients: infuence of TGF-beta 1 gene polymorphism and immunosuppression. Transplant Proc 2002;34:2901-2903.
20. Aoki CA, Borchers AT, Li M, et al. Transforming growth factor beta (TGF-beta) and autoimmunity. Autoimmun Rev 2005;4:450-459.