Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class

Journal of the American Chemical Society

Volumn 132, Issue 46, 2010, Pages 16526-16532

  Andrei, Daniela ^a   Salmon, Debra J ^b   Donzelli, Sonia ^c   Wahab, Azadeh ^c   Klose, John R ^d   Citro, Michael L ^d   Saavedra, Joseph E ^d   Wink, David A ^e   Miranda, Katrina M ^b   Keefer, Larry K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b University of Arizona   (United States)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL GROUPS; BIOLOGICAL TARGETS; CHEMICAL TRAPPING; DIAZENIUMDIOLATES; DUAL MECHANISMS; GLUTATHIONES; HEART FAILURE; METMYOGLOBIN; MICROMOLAR CONCENTRATION; MOUSE HEART; ORDER OF MAGNITUDE; PHYSIOLOGICAL PH; PRODRUGS; STEADY-STATE CONCENTRATIONS; VENTRICULAR MYOCYTES; WILD TYPES;

LEAD COMPOUNDS; NITRIC OXIDE; NITROGEN REMOVAL; OXYGEN; PH EFFECTS;

HYDROLYSIS;

ACETIC ACID; ACETIC ACID DERIVATIVE; AMINE; DIAZENIUMDIOLATE; DIAZENIUMDIOLATE DERIVATIVE; FORMALDEHYDE; GLUTATHIONE; HYDROGEN; METMYOGLOBIN; NITRIC OXIDE; NITROGEN; OXYGEN; PRODRUG; PROTON; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION; DRUG HYDROLYSIS; DRUG STRUCTURE; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE; MOUSE; NITROSYLATION; NONHUMAN; PH; SARCOMERE; STEADY STATE; WILD TYPE;

ANIMALS; AZO COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; MUSCLE CELLS; NITRIC OXIDE DONORS; NITROGEN OXIDES; PRODRUGS;

EID: 78649290159     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106552p     Document Type: Article

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