Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid

Epilepsia

Volumn 51, Issue 10, 2010, Pages 1944-1953

  Pessah, Neta ^a   Kaufmann, Dan ^a   Yagen, Boris ^a,c   Hen, Naama ^a   Wlodarczyk, Bogdan ^c   Finnell, Richard H ^c   Bialer, Meir ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

6 Hz psychomotor seizure test; Anticonvulsants; Neuropathic and persistent pain; Pharmacokinetics; Subcutaneous Metrazol seizure test; Teratogenicity

Indexed keywords

ALPHA CHLORO 2,2,3,3 TETRAMETHYLCYCLOPROPANECARBOXAMIDE; ALPHA FLUORO 2,2,3,3 TETRAMETHYLCYCLOPROPANECARBOXAMIDE; ALPHA FLUORO HYDROXYMETHYL TRIMETHYLCYCLOPROPANECARBOXAMIDE; ANTICONVULSIVE AGENT; DRUG METABOLITE; FORMALDEHYDE; GABAPENTIN; PENTETRAZOLE; UNCLASSIFIED DRUG; VALPROIC ACID;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTINOCICEPTION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG POTENCY; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; EPILEPSY; FIRST PASS EFFECT; LIVER; MOUSE; NERVE LIGATION; NEURAL TUBE DEFECT; NEUROPATHIC PAIN; NEUROTOXICITY; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; ROTAROD TEST; SPINAL NERVE; TEMPORAL LOBE EPILEPSY; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; AMIDES; ANALGESICS; ANIMALS; ANTICONVULSANTS; CYCLOPROPANES; DISEASE MODELS, ANIMAL; EPILEPSY; HUMANS; MICE; NEURAL TUBE DEFECTS; PAIN; PENTYLENETETRAZOLE; RATS; VALPROIC ACID;

EID: 78649267959     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02684.x     Document Type: Article

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