Light-scattering study of the normal human eye lens: Elastic properties and age dependence

IEEE Transactions on Biomedical Engineering

Volumn 57, Issue 12, 2010, Pages 2910-2917

  Bailey, Sheldon T ^a   Twa, Michael D ^b   Gump, Jared C ^a,c   Venkiteshwar, Manoj ^a,d   Bullimore, Mark A ^a   Sooryakumar, Ratnasingham ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c NAVAL SURFACE WARFARE CENTER   (United States)

^d ALCON RESEARCH LTD   (United States)

Author keywords

Brillouin scattering; elastic properties; human eye lens

Indexed keywords

AGE DEPENDENCE; BIOMECHANICAL CHARACTERISTICS; BRILLOUIN LIGHT SCATTERING; BULK MODULUS; ELASTIC PROPERTIES; EXTERNAL FORCE; HUMAN EYE; IN-VITRO; LENS TISSUE; NON-DESTRUCTIVE MEASUREMENT; OCULAR LENS; OPTICAL POWER;

BIOMECHANICS; BRILLOUIN SCATTERING; ELASTIC MODULI; ELASTICITY; HISTOLOGY; LENSES; NONDESTRUCTIVE EXAMINATION; SCATTERING; TISSUE; ULTRASONICS;

OPTICAL INSTRUMENTS;

ACCOMMODATION; ADULT; AGE; AGED; ARTICLE; ELASTICITY; HUMAN; HUMAN TISSUE; LENS; LENS NUCLEUS; LIGHT SCATTERING; MEASUREMENT; YOUNG MODULUS;

ADULT; AGE FACTORS; AGED; BIOMECHANICS; ELASTIC MODULUS; HUMANS; LENS, CRYSTALLINE; LIGHT; MIDDLE AGED; SCATTERING, RADIATION; SPECTRUM ANALYSIS;

EID: 78649248679     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2010.2052393     Document Type: Article

References (46)

1. T. Young, "On the mechanism of the eye", Phil. Tr., London, OH, vol. 1, p. 33, 1801.
2. R. F. Fisher and B. E. Pettet, "The postnasal growth of the capsule of the human crystalline lens", J. Anat., vol. 112, pp. 207-214, 1972.
3. S. Krag and T. T. Andreassen, "Mechanical properties of the human lens capsule", Prog. Retin. Eye Res., vol. 22, pp. 749-767, 2003.
4. R. F. Fisher, "The elastic constants of the human lens", J. Physiol., vol. 212, pp. 147-180, 1971.
5. F. A. Duck, Physical Properties of Tissue: A Comprehensive Reference Book. London, U. K.: Harcourt Brace Jovanovich, 1990.
6. J. F. Koretz, C. A. Cook, and P. L. Kaufman, "Aging of the human lens: Changes in lens shape at zero-diopter accommodation", J. Opt. Soc. Amer. A., vol. 18, pp. 265-272, 2001.
7. J. C. Lim, K. L. Walker, T. Sherwin, K. L. Schey, and P. J. Donaldson, "Confocal microscopy reveals zones of membrane remodeling in the outer cortex of human lens", Invest. Ophth. Vis. Sci., vol. 50, pp. 4304-4310, 2009.
8. K. R. Heys, S. L. Cram, and R. J. W. Truscott, "Massive increase in the stiffness of the human lens nucleus with age: The basis for presbyopia?", Mol. Vis., vol. 10, pp. 956-963, 2004.
9. H. A. Weeber, G. Eckert, W. Pechhold, and G. L. Van Der Heijde, "Stiffness gradient in the crystalline lens", Graef. Arch. Clin. Exp., vol. 245, pp. 1357-1366, 2007.
10. T. N. Erpeldin, K. W. Hollman, and M. O'Donnell, "Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force", Exp. Eye Res., vol. 84, pp. 332-341, 2007.
11. A. S. Pine, "Brillouin scattering in semiconductors", in Light Scattering in Solids, Topics in Applied Physics, M. Cardona, Ed. Berlin, Germany/New York: Springer-Verlag, 1975.
12. J. M. Karanikas, R. Sooryakumar, and J. M. Phillips, "Brillouin crosssections and localized phonons in CaF2/Si heterostructures", Phys. Rev. B (Rapid Commun.), vol. 39, pp. 1388-1391, 1989.
13. J. Bak and R. Sooryakumar, "Pressure dependence of the refractive index of methanolethanol solution; A Brillouin scattering study", High Pressure Res., vol. 11, pp. 329-336, 1994.
14. X. Zhang, R. Sooryakumar, A. G. Every, and M. H. Manghnani, "Observation of organ-pipe acoustic excitations in supported thin films", Phys. Rev. B (Rapid Commun.), vol. 64, pp. R081402-1-R081402-4, 2001.
15. X. Zhang, R. Sooryakumar, and K. Bussmann, "Confinement and transverse standing acoustic resonances in free-standing membranes", Phys. Rev. B, vol. 68, pp. 115430-1-115430-5, 2003.
16. J. Karanikas, R. Sooryakumar, C. Carlone, and M. Aubin, "Elastic properties of trigonal laminar systems: Brillouin scattering study of Hf1-r Zrx S2", Phys. Rev. B, vol. 41, pp. 1516-1520, 1990.
17. N. Brown, "The change in shape and internal form of the lens of the eye on accommodation", Exp. Eye Res., vol. 15, pp. 441-459, 1973.
18. K. Richdale, M. Bullimore, and K. Zadnik, "Lens thickness with age and accommodation by optical coherence tomography", Ophthal. Physl. Opt., vol. 28, pp. 441-417, 2008.
19. M. Dubbelman, "Change in shape of the aging human crystalline lens with accommodation", Vis. Res., vol. 45, pp. 117-132, 2005.
20. C. E. Jones, D. A. Atchison, R. Meder, and J. M. Pope, "Refractive index distribution and optical properties of the isolated human lens measured using magnetic resonance imaging (MRI)", Vis. Res., vol. 45, pp. 2352-2366, 2005.
21. J. M. Vaughan and J. T. Randall, "Brillouin scattering, density and elastic properties of the lens and cornea of the eye", Nature, vol. 284, pp. 489-491, 1980.
22. M. Reilly and N. Ravi, "Microindentation of the young porcine ocular lens", J. Biomech. Eng., vol. 131, pp. 044502-1-044502-4, 2009.
23. H. J. Burd, G. S. Wilde, and S. J. Judge, "Can reliable values of Young's modulus be deduced from Fisher's (1971) spinning lens measurements?", Vis. Res., vol. 46, pp. 1346-1360, 2006.
24. J. Nordmanm, G. Mack, and G. Mack, "Nucleus of the human lens: III. Its separation, its hardness", Ophthal. Res., vol. 6, pp. 216-222, 1974.
25. A. P. A. Beers and G. L. Van Der Heijde, "Presbyopia and velocity of sound in the lens", Optom. Vis. Sci., vol. 71, pp. 250-253, 1994.
26. P. Breitenfeld, T. Ripken, and H. Lubaschowski, "Finite element methodsimulation of the human lens during accommodation", in Proc. SPIE, vol. 5863, pp. 1-9, 2005.
27. G. Scarcelli and S. H. Yun, "Confocal Brillouin microscopy for threedimensional mechanical imaging", Nature, vol. 2, pp. 39-43, 2007.
28. A. Glasser and M. C. W. Campbell, "On potential causes of presbyopia a reply", Vis. Res., vol. 39, pp. 1267-1272, 1999.
29. R. A. Schachar, "Comment on the publication 'Stiffness gradient in the crystalline lens' by H. A. Weeber et al.", Graef. s Arch. Clin. Exp., vol. 245, pp. 1405-1406, 2007.
30. B. K. Pierscionek, "Surface refractive index of the eye lens determined with an optic fibre sensor", J. Opt. Soc. Amer. A., vol. 10, pp. 1867-1871, 1993.
31. B. K. Pierscionek, "Variations in refractive index and absorbance of 670 nm light with age and cataract formation in human lenses", Exp. Eye Res., vol. 60, pp. 407-413, 1995.
32. R. A. Weale, "Why we need reading-glasses before a zimmer-frame", Vi s. Res., vol. 40, pp. 2233-2240, 2000.
33. R. F. Fisher, "Elastic constants of the human lens capsule", J. Physiol., vol. 201, pp. 1-19, 1969.
34. R. F. Fisher and B. J. Pettet, "Presbyopia and the water content of the human crystalline lens", J. Physiol., vol. 234, pp. 443-447, 1973.
35. T. Wanko and M. A. Gavin, "The fine structure of the lens epithelium. An electron microscopic study", Arch. Ophth., vol. 60, pp. 868-879, 1958.
36. H. A. Weeber, "On the relationship between lens stiffness and accommodate amplitude", Exp. Eye Res., vol. 85, pp. 602-607, 2007.
37. A. Abolmaali, R. A. Schachar, and T. Le., "Sensitivity study of human crystalline lens accommodation", Comput. Methods Programs Biomed., vol. 85, pp. 77-90, 2007.
38. B. K. Pierscionek, "Presbyopia-Effect of refractive index", Clin. Exp. Optom., vol. 73, pp. 23-30, 1990.
39. B. K. Pierscionek and R. C. Augusteyn, "Structure/function relationship between optics and biochemistry of the lens", Lens Eye Toxic Res., vol. 8, pp. 229-243, 1991.
40. P. P. Fagerholm, B. T. Philipson, and B. Lindstrom, "Normal human lens-The distribution of protein", Exp. Eye Res., vol. 33, pp. 615-620, 1981.
41. J. Keenan, D. F. Orr, and B. K. Pierscionek, "Patterns of crystallin distribution in porcine eye lenses", Mol. Vis., vol. 14, pp. 1245-1253, 2008.
42. C. E. Jones, D. A. Atchison, and J. M. Pope, "Changes in lens dimensions and refractive index with age and accommodation", Optom. Vis. Sci., vol. 84, pp. 990-995, 2007.
43. S. Koopmans, T. Terwee, J. Barkhof, H. Haitjema, and A. Kooijman, "Polymer refilling of presbyopic human lenses in vitro restores the ability to undergo accommodative changes", Invest. Ophth. Vis. Sci., vol. 44, pp. 250-257, 2003.
44. A. Ho, P. Erickson, F. Manns, T. Pham, and J. M. Parel, "Theoretical analysisofaccommodation amplitude and ametropia correctionbyvarying refractive index in Phaco-Ersatz", Optom. Vis. Sci., vol. 78, no. 6, pp. 405-410, 2001.
45. E. Haefliger and J. M. Parel, "Accommodation of an endocapsular silicone lens (Phaco-Ersatz) in the aging rhesus monkey", J. Refract. Corneal Surg., vol. 10, no. 5, pp. 550-555, 1994.
46. R. Myers and R. Krueger, "Novel approaches to correction of presbyopia with laser modification of the crystalline lens", J. Refract. Surg., vol. 14, pp. 136-139, 1998.