Grand Challenge Commentary: Exploiting single-cell variation for new antibiotics

Nature Chemical Biology

Volumn 6, Issue 12, 2010, Pages 873-875

  Strauss, Erick ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; INDOLE; PENICILLIN G;

ALTRUISM; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL CELL; BACTERIUM CULTURE; BIOFILM; CELL DIVISION; CELL GROWTH; CELL MUTANT; CELL POPULATION; CELL WALL; DNA METHYLATION; DNA REPLICATION; DRUG MECHANISM; GENE EXPRESSION; GENE MUTATION; GENOMICS; HUMAN; INFECTION; METABOLOMICS; MICROFLUIDIC ANALYSIS; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NOTE; PHENOTYPIC VARIATION; POPULATION DYNAMICS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEOMICS; STAPHYLOCOCCUS AUREUS; TRANSCRIPTOMICS;

EID: 78649245648     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.483     Document Type: Note

References (20)

1. Fischbach, M. A. & Walsh, C. T. Science 325, 1089-1093 (2009).
2. Davies, J. & Davies, D. Microbiol. Mol. Biol. Rev. 74, 417-433 (2010).
3. Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Nat. Rev. Drug Discov. 6, 29-40 (2007).
4. Dhar, N. & McKinney, J. D. Curr. Opin. Microbiol. 10, 30-38 (2007).
5. Bigger, J. W. Lancet 244, 497-500 (1944).
6. Avery, S. V. Nat. Rev. Microbiol. 4, 577-587 (2006).
7. Smits, W. K., Kuipers, O. P. & Veening, J. W. Nat. Rev. Microbiol. 4, 259-271 (2006).
8. Lee, H. H., Molla, M. N., Cantor, C. R. & Collins, J. J. Nature 467, 82-85 (2010).
9. West, S. A., Griffin, A. S., Gardner, A. & Diggle, S. P. Nat. Rev. Microbiol. 4, 597-607 (2006).
10. Stewart, G. R., Robertson, B. D. & Young, D. B. Nat. Rev. Microbiol. 1, 97-105 (2003).
11. Gomez, J. E. & McKinney, J. D. Tuberculosis (Edinb.) 84, 29-44 (2004).
12. Barry, C. E. et al. Nat. Rev. Microbiol. 7, 845-855 (2009).
13. Brehm-Stecher, B. F. & Johnson, E. A. Microbiol. Mol. Biol. Rev. 68, 538-559 (2004).
14. Schmid, A., Kortmann, H., Dittrich, P. S. & Blank, L. M. Curr. Opin. Biotechnol. 21, 12-20 (2010).
15. Raj, A. & van Oudenaarden, A. Annu. Rev. Biophys. 38, 255-270 (2009).
16. Wang, D. & Bodovitz, S. Trends Biotechnol. 28, 281-290 (2010).
17. Raj, A. & van Oudenaarden, A. Cell 135, 216-226 (2008).
18. Walsh, C. Nat. Rev. Microbiol. 1, 65-70 (2003).
19. Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622-1625 (2004).
20. Spiller, D. G., Wood, C. D., Rand, D. A. & White, M. R. H. Nature 465, 736-745 (2010).