Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats

Inhalation Toxicology

Volumn 22, Issue 13, 2010, Pages 1116-1126

  Umeda, Yumi ^a   Matsumoto, Michiharu ^a   Aiso, Shigetoshi ^a   Nishizawa, Tomoshi ^a   Nagano, Kasuke ^a   Arito, Heihachiro ^a   Fukushima, Shoji ^a  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

1; 2 dichloropropane; carcinogenicity; chronic toxicity; inhalation; mouse; rat

Indexed keywords

1,2 DICHLOROPROPANE; BILIRUBIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ADRENAL DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD TOXICITY; BODY WEIGHT; CANCER INCIDENCE; CARCINOGENICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EPITHELIUM HYPERPLASIA; FEMALE; FISCHER 344 RAT; FOOD INTAKE; HEMOLYTIC ANEMIA; HYPERPLASIA; LIVER INJURY; LIVER TOXICITY; LIVER WEIGHT; MALE; NEUROEPITHELIOMA; NONHUMAN; NOSE CAVITY TUMOR; PAPILLOMA; PRECANCER; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; SPLEEN WEIGHT; SQUAMOUS CELL HYPERPLASIA; SQUAMOUS CELL METAPLASIA; SURVIVAL; TOXICITY TESTING;

ANIMALS; CARCINOGENS; EPITHELIUM; FEMALE; HYPERPLASIA; INHALATION EXPOSURE; MALE; METAPLASIA; NASAL CAVITY; NOSE NEOPLASMS; PROPANE; RATS; RATS, INBRED F344; TOXICITY TESTS, CHRONIC;

RATTUS;

EID: 78649242561     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2010.526973     Document Type: Article

References (54)

1. Acheson ED, Cowdell RH, Hadfeld E, Macbeth RG. 1968. Nasal cancer in woodworkers in the furniture industry. Br Med J 2:587-596.
2. Acheson ED. 1976. Nasal cancer in the furniture and boot and shoe manufacturing industries. Prev Med 5:295-315.
3. American Conference of Governmental Industrial Hygienists (ACGIH). 2006. Documentation of the Treshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) [CD-ROM]. Cincinnati: ACGIH.
4. American Conference of Governmental Industrial Hygienists (ACGIH). 2009. Guide to Occupational Exposure Values. Cincinnati: ACGIH.
5. Bannasch P, Griesemer RA, Anders F, Becker R, Cabral JR, Della Porta G, Feron VJ, Henschler D, Ito N, Kroes R. 1986. Long-term assays for carcinogenicity in animals. IARC Sci Publ:13-83.
6. Barufni A, Cirla AM, Pisati G, Ratti R, Zedda S. 1989. Allergic contact dermatitis from 1,2-dichloropropane. Contact Derm 20:379-380.
7. Bruckner JV, MacKenzie WF, Ramanathan R, Muralidhara S, Kim HJ, Dallas CE. 1989. Oral toxicity of 1,2-dichloropropane: acute, short-term, and long-term studies in rats. Fundam Appl Toxicol 12:713-730.
8. Buiatti E, Geddes M, Carnevale F, Merler E. 1983. Nasal cavity and parana-sal sinus tumors in woodworkers and shoemakers in Italy compared to other countries. In: Reznik G, Stinson SF (eds), Nasal Tumors in Animals and Man. Vol 1, Anatomy, Physiology, and Epidemiology. Boca Raton: CRC Press.
9. Butterworth BE, Popp JA, Conolly RB, Goldsworthy TL. 1992. Chemically induced cell proliferation in carcinogenesis. IARC Sci Publ:279-305.
10. De Lorenzo F, Degl'Innocenti S, Ruocco A, Silengo L, Cortese R. 1977. Mutagenicity of pesticides containing 1,3-dichloropropene. Cancer Res 37:1915-1917.
11. Deutsche Forschungsgemeinschaft. 1998. 1,2-Dichloropropane. In: Greim H (ed.), Occupational Toxicants. Critical Data Evaluation for MAK Values and Classifcation of Carcinogens, vol 9. Weinheim, Germany: Wiley-VCH Verlag GmbH, 21-39.
12. Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S. 1987. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen 10 Suppl 10:1-175.
13. Gaylor DW, Kodell RL. 2002. A procedure for developing risk-based reference doses. Regul Toxicol Pharmacol 35:137-141.
14. Grzywa Z, Rudzki E. 1981. Dermatitis from dichloropropane. Contact Derm 7:151-152.
15. Haemisegger ER, Jones AD, Reinhardt FL. 1985. EPA's experience with assessment of site-specifc environmental problems: a review of IEMD's geographic study of Philadelphia. J Air Pollut Control Assoc 35: 809-815.
16. Imberti R, Mapelli A, Colombo P, Richelmi P, Bertè F, Bellomo G. 1990. 1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutath-ione (GSH) depletion and is modulated by factors afecting intracellular GSH. Arch Toxicol 64:459-465.
17. International Agency for Research on Cancer (IARC). 1992. Respiratory system. In: Mohr U (ed.) International Classifcation of Rodent Tumours. Part I: Te Rat. 1. IARC Scientifc Publications, No 122. Lyon: IARC.
18. International Agency for Research on Cancer (IARC). 1999. 1,2-Dichloropro-pane. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part Tree). IARC Monographs Vol. 71. Lyon: IARC, 1393-1400.
19. Japan Ministry of the Environment. 2004. 1,2-Dichloropropane. In: Environmental Risk Assessment of Chemicals, 3. Tokyo: Environmental Risk Assessment Ofce. 261-79 (In Japanese).
20. Japan Ministry of the Environment. 2006. Assessment of Health Risk of 1,2-Dichloroethane. [Online]. Available at: http://www.env.go.jp/info/iken/ h180711a/a-5.pdf. Accessed on April 22, 2010 (In Japanese).
21. Japan Ministry of the Environment. 2008. Chemical Substance Fact Sheets, Pollutant Release and Transfer Register Substances. [Online]. Available at http://www2.env.go.jp/ chemi/prtr.html. Accessed on April 4, 2010.
22. Kaplan EL, Meier P. 1958. Nonparametric estimation from incomplete observations. Am Stat Assoc J 53, 457-481.
23. Larcan A, Lambert H, Laprevote MC, Gustin B. 1977. Acute poisoning induced by dichloropropane. Acta Pharmacol Toxicol (Copenh) 41 Suppl 2:330.
24. Magnavita N, Sacco A, Bevilacqua L, D'Alessandris T, Bosman C. 2003. Aesthesioneuroblastoma in a woodworker. Occup Med (Lond) 53:231-234.
25. Monticello TM, Morgan KT, Uraih L. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274.
26. Morgan KT, Harkema JR. 1996. Nasal neoplasia. In: Jones TC, Dungworth DL, Mohr U (eds), Monographs on Pathology of Laboratory Animals, Respiratory System, 2nd edition. Berlin: Springer-Verlag, 87-104.
27. Nagano K, Katagiri T, Aiso S, Senoh H, Sakura Y, Takeuchi T. 1997. Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice. Exp Toxicol Pathol 49:97-104.
28. National Institute for Occupational Safety and Health (NIOSH). 2002. National Occupational Exposure Survey Conducted from 1981 to1983. [Online]. Available at: http://www.cdc.gov/noes.html. Accessed on 19 April 2010.
29. National Research Council (NRC). 1996. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, Institute of Laboratory Animal Resources Commission on Life Sciences, NRC.
30. National Toxicology Program (NTP). 1986. Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (propylene dichloride) in F344/N rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 263. Bethesda: NTP.
31. Nitschke KD, Johnson KA, Wacherle DL, Phillips JE, Dittenber DA. 1988. Propylene dichloride: A 13-wk inhalation toxicity study with rats, mice, and rabbits. Final Report. Midland, MI: Dow Chemical Company, Mammalian and Environmental Toxicology Research Laboratory.
32. Organization for Economic Co-operation and Development. 1998. OECD Principles on Good Laboratory Practice. OECD series on principles of good laboratory practice and compliance monitoring No.1. ENV/MC/ CHEM (98) 17. Paris: OECD.
33. Organization for Economic Co-operation and Development. 2005. Screening Information Data Set (SIDS), 1,2-dichlorepropane. [Online]. Available at: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html. Accessed on 9 September 2010.
34. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. 1977. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer 35:1-39.
35. Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S, Wahrendorf J. 1980. Guidelines for simple, sensitive signifcance tests for carcinogenic efects in long-term animal experiments. IARC Monogr Eval Carcinog Risk Chem Hum Suppl:311-426.
36. Pozzani UC, Weil CS, Carpenter CP. 1959. Te toxicological basis of threshold limit values: 5. Te experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. Am Ind Hyg Assoc J 20:364-369.
37. Pozzi C, Marai P, Ponti R, Dell'Oro C, Sala C, Zedda S, Locatelli F. 1985. Toxicity in man due to stain removers containing 1,2-dichloropropane. Br J Ind Med 42:770-772.
38. Principe P, Dogliotti E, Bignami M, Crebelli R, Falcone E, Fabrizi M, Conti G, Comba P. 1981. Mutagenicity of chemicals of industry and agricultural relevance in Salmonella, Streptomyces and Aspergillus. J Sci Food Agric 32:826-832.
39. Reid JB. 2001. Saturated halogenated aliphatic hydrocarbons two to four carbon. In: Bingham E, Cohrssen B, Powell CHRONic (eds), Patty's Toxicology. New York: John Wiley & Sons.
40. Renne R, Brix A, Harkema J, Herbert R, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37:5S-73S.
41. Schuller HM, Gregg M, Reznik GK. 1990. Tumours of the nasal cavity. Turusov VS, More U (eds), Pathology of Tumours in Laboratory Animals, vol. 1, Tumours of the Rat, 2nd edition, 99. Lyon: IARC.
42. Sidorenko GI, Tsulaya VR, Bonashevskaya TI, Shaipak VM. 1979. Study of the combined action of a group of chlorine derivatives of hydrocarbons entering the organism by inhalation. Environ Health Perspect 30:13-18.
43. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS. 1969. Range-fnding toxicity data: List VII. Am Ind Hyg Assoc J 30:470-476.
44. Sontag JM, Page NP, Safotti U. 1976. Guidelines for Carcinogen Bioassay in Small Rodents. NCI-CG-TR-1. Washington DC: DHEW.
45. Torel JM, Bercof E, Massari P, Droy JM, Chassagne P, Proust B, Hemet J, Bourreille J. 1986. [Toxicity of 1,2 dichloropropane. A case with portal hypertension]. J Toxicol Clin Exp 6:247-252.
46. Torjussen W, Solberg LA, Høgetveit AC. 1979. Histopathological changes of the nasal mucosa in active and retired nickel workers. Br J Cancer 40:568-580. (Pubitemid 10190211)
47. United States Environmental Protection Agency (U.S. EPA). 1994. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry.FPA/600/8-90/066F. Washington, DC: U.S. EPA.
48. United States Environmental Protection Agency (U.S. EPA). 1999. Guidelines for Carcinogen Risk Assessment, Risk Assessment Forum, NCEA-F-0644.
49. Washington DC: U.S. EPA. United States Environmental Protection Agency (U.S. EPA). 2008. 1,2-Dichlo-roethane (CASRN 107-06-2) Integrated Risk Information System. [Online]. Available at: http://www.epa.gov/iris/subst/0149. htm. Accessed on 19 April 2010.
50. United States Environmental Protection Agency (U.S. EPA). 2009a. Benchmark dose software version 2.1.1 User's manual. 53-BMDS-RPT-0028.
51. Washington DC: U.S. EPA. United States Environmental Protection Agency (U.S. EPA). 2009b. Toxics Release Inventory Program, TRI Explorer, Releases: Chemical Report. [Online]. Available at: http://www.epa.gov/tri. Accessed on 29 March 2010.
52. Von Der Hude W, Scheutwinkel M, Gramlich U, Fissler B, Basler A. 1987. Genotoxicity of three-carbon compounds evaluated in the SCE test in vitro. Environ Mutagen 9:401-410.
53. World Health Organization (WHO). (1993). Environmental Health Criteria 146. 1,3-Dichloropropane, 1,2-Dichloropropane and Mixtures. International Programme on Chemical Safety (IPCS). Geneva: WHO.
54. World Health Organization (WHO). (1994). Environmental Health Criteria 170. Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health-based Exposure Limits. International Programme on Chemical Safety (IPCS). Geneva: WHO.