메뉴 건너뛰기




Volumn 69, Issue 12, 2010, Pages 2125-2130

Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: Analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOPHOSPHAMIDE; INFLIXIMAB; METHYLPREDNISOLONE; PREDNISONE;

EID: 78549283449     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.131953     Document Type: Article
Times cited : (49)

References (45)
  • 1
    • 0014116172 scopus 로고
    • The use of alkylating agents in the treatment of Wegener's granulomatosis
    • Hollander D, Manning RT. The use of alkylating agents in the treatment of Wegener's granulomatosis. Ann Intern Med 1967;67:393-8.
    • (1967) Ann Intern Med , vol.67 , pp. 393-398
    • Hollander, D.1    Manning, R.T.2
  • 2
    • 0015764397 scopus 로고
    • Wegener's granulomatosis: Studies in eighteen patients and a review of the literature
    • Fauci AS, Wolff SM. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore) 1973;52:535-61.
    • (1973) Medicine (Baltimore) , vol.52 , pp. 535-561
    • Fauci, A.S.1    Wolff, S.M.2
  • 3
    • 15644362541 scopus 로고    scopus 로고
    • A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis
    • Guillevin L, Cordier JF, Lhote F, et al. A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis. Arthritis Rheum 1997;40:2187-98.
    • (1997) Arthritis Rheum , vol.40 , pp. 2187-2198
    • Guillevin, L.1    Cordier, J.F.2    Lhote, F.3
  • 4
    • 0031714120 scopus 로고    scopus 로고
    • Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement: A prospective, randomized study
    • Haubitz M, Schellong S, Göbel U, et al. Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement: a prospective, randomized study. Arthritis Rheum 1998;41:1835-44.
    • (1998) Arthritis Rheum , vol.41 , pp. 1835-1844
    • Haubitz, M.1    Schellong, S.2    Göbel, U.3
  • 5
    • 0030993763 scopus 로고    scopus 로고
    • Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis
    • Adu D, Pall A, Luqmani RA, et al. Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis. QJM 1997;90:401-9.
    • (1997) QJM , vol.90 , pp. 401-409
    • Adu, D.1    Pall, A.2    Luqmani, R.A.3
  • 6
    • 66149168812 scopus 로고    scopus 로고
    • Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: A randomized trial
    • de Groot K, Harper L, Jayne DR, et al. Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial. Ann Intern Med 2009;150:670-80.
    • (2009) Ann Intern Med , vol.150 , pp. 670-680
    • De Groot, K.1    Harper, L.2    Jayne, D.R.3
  • 8
    • 0037447483 scopus 로고    scopus 로고
    • Use of a cyclophosphamide-induction methotrexate-maintenance regimen for the treatment of Wegener's granulomatosis: Extended follow-up and rate of relapse
    • Langford CA, Talar-Williams C, Barron KS, et al. Use of a cyclophosphamide-induction methotrexate-maintenance regimen for the treatment of Wegener's granulomatosis: extended follow-up and rate of relapse. Am J Med 2003;114:463-9.
    • (2003) Am J Med , vol.114 , pp. 463-469
    • Langford, C.A.1    Talar-Williams, C.2    Barron, K.S.3
  • 9
    • 0020656868 scopus 로고
    • Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
    • Fauci AS, Haynes BF, Katz P, et al. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983;98:76-85.
    • (1983) Ann Intern Med , vol.98 , pp. 76-85
    • Fauci, A.S.1    Haynes, B.F.2    Katz, P.3
  • 10
    • 0026505235 scopus 로고
    • Wegener granulomatosis: An analysis of 158 patients
    • Hoffman GS, Kerr GS, Leavitt RY, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 1992;116:488-98.
    • (1992) Ann Intern Med , vol.116 , pp. 488-498
    • Hoffman, G.S.1    Kerr, G.S.2    Leavitt, R.Y.3
  • 11
    • 0028126831 scopus 로고
    • Treatment of systemic vasculitis with cyclophosphamide and steroids: Daily oral low-dose cyclophosphamide administration after failure of a pulse intravenous high-dose regimen in four patients
    • Généreau T, Lortholary O, Leclerq P, et al. Treatment of systemic vasculitis with cyclophosphamide and steroids: daily oral low-dose cyclophosphamide administration after failure of a pulse intravenous high-dose regimen in four patients. Br J Rheumatol 1994;33:959-62.
    • (1994) Br J Rheumatol , vol.33 , pp. 959-962
    • Généreau, T.1    Lortholary, O.2    Leclerq, P.3
  • 12
    • 0030062483 scopus 로고    scopus 로고
    • Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis
    • Nachman PH, Hogan SL, Jennette JC, et al. Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996;7:33-9.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 33-39
    • Nachman, P.H.1    Hogan, S.L.2    Jennette, J.C.3
  • 13
    • 27644437166 scopus 로고    scopus 로고
    • Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis
    • Hogan SL, Falk RJ, Chin H, et al. Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann Intern Med 2005;143:621-31.
    • (2005) Ann Intern Med , vol.143 , pp. 621-631
    • Hogan, S.L.1    Falk, R.J.2    Chin, H.3
  • 14
    • 58149180323 scopus 로고    scopus 로고
    • Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    • Pagnoux C, Mahr A, Hamidou MA, et al. Azathioprine or methotrexate maintenance for ANCA-associated vasculitis. N Engl J Med 2008;359:2790-803.
    • (2008) N Engl J Med , vol.359 , pp. 2790-2803
    • Pagnoux, C.1    Mahr, A.2    Hamidou, M.A.3
  • 15
    • 0025183423 scopus 로고
    • The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis
    • Leavitt RY, Fauci AS, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 1990;33:1101-7.
    • (1990) Arthritis Rheum , vol.33 , pp. 1101-1107
    • Leavitt, R.Y.1    Fauci, A.S.2    Bloch, D.A.3
  • 16
    • 0028158243 scopus 로고
    • Nomenclature of systemic vasculitides. Proposal of an international consensus conference
    • Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994;37:187-92.
    • (1994) Arthritis Rheum , vol.37 , pp. 187-192
    • Jennette, J.C.1    Falk, R.J.2    Andrassy, K.3
  • 17
    • 0030070089 scopus 로고    scopus 로고
    • Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients
    • Guillevin L, Lhote F, Gayraud M, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 1996;75:17-28.
    • (1996) Medicine (Baltimore) , vol.75 , pp. 17-28
    • Guillevin, L.1    Lhote, F.2    Gayraud, M.3
  • 18
    • 34248218149 scopus 로고    scopus 로고
    • EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: Focus on anti-neutrophil cytoplasm antibody-associated vasculitis
    • Hellmich B, Flossmann O, Gross WL, et al. EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis 2007;66:605-17.
    • (2007) Ann Rheum Dis , vol.66 , pp. 605-617
    • Hellmich, B.1    Flossmann, O.2    Gross, W.L.3
  • 19
    • 0028150660 scopus 로고
    • Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis
    • Luqmani RA, Bacon PA, Moots RJ, et al. Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 1994;87:671-8.
    • (1994) QJM , vol.87 , pp. 671-678
    • Luqmani, R.A.1    Bacon, P.A.2    Moots, R.J.3
  • 20
    • 34447285291 scopus 로고    scopus 로고
    • Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis
    • Jayne DR, Gaskin G, Rasmussen N, et al. Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol 2007;18:2180-8.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2180-2188
    • Jayne, D.R.1    Gaskin, G.2    Rasmussen, N.3
  • 21
    • 0000885136 scopus 로고
    • Non parametric estimation from incomplete observations
    • Kaplan E, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958;87:161-7.
    • (1958) J Am Stat Assoc , vol.87 , pp. 161-167
    • Kaplan, E.1    Meier, P.2
  • 22
    • 0015898827 scopus 로고
    • Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data
    • Peto R, Pike MC. Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics 1973;29:579-84.
    • (1973) Biometrics , vol.29 , pp. 579-584
    • Peto, R.1    Pike, M.C.2
  • 24
    • 12544253745 scopus 로고    scopus 로고
    • Etanercept plus standard therapy for Wegener's granulomatosis
    • The Wegener's Granulomatosis Etanercept Trial (WGET) Research Group
    • The Wegener's Granulomatosis Etanercept Trial (WGET) Research Group. Etanercept plus standard therapy for Wegener's granulomatosis. N Engl J Med 2005;352:351-61.
    • (2005) N Engl J Med , vol.352 , pp. 351-361
  • 25
    • 1542288825 scopus 로고    scopus 로고
    • Prospective study of TNFalpha blockade with infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis
    • Booth A, Harper L, Hammad T, et al. Prospective study of TNFalpha blockade with infliximab in anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol 2004;15:717-21.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 717-721
    • Booth, A.1    Harper, L.2    Hammad, T.3
  • 26
    • 50249107909 scopus 로고    scopus 로고
    • Long-term follow-up of relapsing/refractory anti-neutrophil cytoplasm antibody associated vasculitis treated with the lymphocyte depleting antibody alemtuzumab (CAMPATH-1H)
    • Walsh M, Chaudhry A, Jayne D. Long-term follow-up of relapsing/refractory anti-neutrophil cytoplasm antibody associated vasculitis treated with the lymphocyte depleting antibody alemtuzumab (CAMPATH-1H). Ann Rheum Dis 2008;67:1322-7.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1322-1327
    • Walsh, M.1    Chaudhry, A.2    Jayne, D.3
  • 28
    • 34249795465 scopus 로고    scopus 로고
    • Induction of remission in active anti-neutrophil cytoplasmic antibody-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide
    • Stassen PM, Cohen Tervaert JW, Stegeman CA. Induction of remission in active anti-neutrophil cytoplasmic antibody-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide. Ann Rheum Dis 2007;66:798-802.
    • (2007) Ann Rheum Dis , vol.66 , pp. 798-802
    • Stassen, P.M.1    Cohen Tervaert, J.W.2    Stegeman, C.A.3
  • 29
    • 0029964713 scopus 로고    scopus 로고
    • Intravenous immunoglobulin as sole therapy for systemic vasculitis
    • Jayne DR, Lockwood CM. Intravenous immunoglobulin as sole therapy for systemic vasculitis. Br J Rheumatol 1996;35:1150-3.
    • (1996) Br J Rheumatol , vol.35 , pp. 1150-1153
    • Jayne, D.R.1    Lockwood, C.M.2
  • 30
    • 32844456754 scopus 로고    scopus 로고
    • Clinical efficacy of intravenous immunoglobulin for patients with MPO-ANCA-associated rapidly progressive glomerulonephritis
    • Ito-Ihara T, Ono T, Nogaki F, et al. Clinical efficacy of intravenous immunoglobulin for patients with MPO-ANCA-associated rapidly progressive glomerulonephritis. Nephron Clin Pract 2006;102:c35-42.
    • (2006) Nephron Clin Pract , vol.102
    • Ito-Ihara, T.1    Ono, T.2    Nogaki, F.3
  • 31
    • 0029052713 scopus 로고
    • Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin
    • Richter C, Schnabel A, Csernok E, et al. Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin. Clin Exp Immunol 1995;101:2-7.
    • (1995) Clin Exp Immunol , vol.101 , pp. 2-7
    • Richter, C.1    Schnabel, A.2    Csernok, E.3
  • 32
    • 38149065308 scopus 로고    scopus 로고
    • Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: Results of a multicenter, prospective, open-label study of twenty-two patients
    • Martinez V, Cohen P, Pagnoux C, et al. Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patients. Arthritis Rheum 2008;58:308-17.
    • (2008) Arthritis Rheum , vol.58 , pp. 308-317
    • Martinez, V.1    Cohen, P.2    Pagnoux, C.3
  • 33
    • 61449238213 scopus 로고    scopus 로고
    • EULAR recommendations for the management of primary small and medium vessel vasculitis
    • Mukhtyar C, Guillevin L, Cid MC, et al. EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 2009;68:310-17.
    • (2009) Ann Rheum Dis , vol.68 , pp. 310-317
    • Mukhtyar, C.1    Guillevin, L.2    Cid, M.C.3
  • 34
    • 39749124664 scopus 로고    scopus 로고
    • BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis
    • Lapraik C, Watts R, Bacon P, et al. BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Rheumatology (Oxford) 2007;46:1615-16.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1615-1616
    • Lapraik, C.1    Watts, R.2    Bacon, P.3
  • 35
    • 0344395547 scopus 로고    scopus 로고
    • Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis
    • Klemmer PJ, Chalermskulrat W, Reif MS, et al. Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis. Am J Kidney Dis 2003;42:1149-53.
    • (2003) Am J Kidney Dis , vol.42 , pp. 1149-1153
    • Klemmer, P.J.1    Chalermskulrat, W.2    Reif, M.S.3
  • 36
    • 31944440872 scopus 로고    scopus 로고
    • Rituximab for refractory Wegener's granulomatosis: Report of a prospective, open-label pilot trial
    • Keogh KA, Ytterberg SR, Fervenza FC, et al. Rituximab for refractory Wegener's granulomatosis: report of a prospective, open-label pilot trial. Am J Respir Crit Care Med 2006;173:180-7.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 180-187
    • Keogh, K.A.1    Ytterberg, S.R.2    Fervenza, F.C.3
  • 37
    • 50249179755 scopus 로고    scopus 로고
    • Infliximab efficacy and safety against refractory systemic necrotising vasculitides: Long-term follow-up of 15 patients
    • Josselin L, Mahr A, Cohen P, et al. Infliximab efficacy and safety against refractory systemic necrotising vasculitides: long-term follow-up of 15 patients. Ann Rheum Dis 2008;67:1343-6.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1343-1346
    • Josselin, L.1    Mahr, A.2    Cohen, P.3
  • 38
    • 51849091965 scopus 로고    scopus 로고
    • Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: Comparison of two independent cohorts
    • Pagnoux C, Hogan SL, Chin H, et al. Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. Arthritis Rheum 2008;58:2908-18.
    • (2008) Arthritis Rheum , vol.58 , pp. 2908-2918
    • Pagnoux, C.1    Hogan, S.L.2    Chin, H.3
  • 39
    • 0030052126 scopus 로고    scopus 로고
    • Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis
    • Hogan SL, Nachman PH, Wilkman AS, et al. Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996;7:23-32.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 23-32
    • Hogan, S.L.1    Nachman, P.H.2    Wilkman, A.S.3
  • 40
    • 0033863551 scopus 로고    scopus 로고
    • Microscopic polyangiitis with alveolar hemorrhage. A study of 29 cases and review of the literature
    • Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P)
    • Lauque D, Cadranel J, Lazor R, et al. Microscopic polyangiitis with alveolar hemorrhage. A study of 29 cases and review of the literature. Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). Medicine (Baltimore) 2000;79:222-33.
    • (2000) Medicine (Baltimore) , vol.79 , pp. 222-233
    • Lauque, D.1    Cadranel, J.2    Lazor, R.3
  • 41
    • 1242336945 scopus 로고    scopus 로고
    • Predicting mortality in systemic Wegener's granulomatosis: A survival analysis based on 93 patients
    • Bligny D, Mahr A, Toumelin PL, et al. Predicting mortality in systemic Wegener's granulomatosis: a survival analysis based on 93 patients. Arthritis Rheum 2004;51:83-91.
    • (2004) Arthritis Rheum , vol.51 , pp. 83-91
    • Bligny, D.1    Mahr, A.2    Toumelin, P.L.3
  • 42
    • 0035083681 scopus 로고    scopus 로고
    • Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: Analysis of four prospective trials including 278 patients
    • Gayraud M, Guillevin L, le Toumelin P, et al. Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum 2001;44:666-75.
    • (2001) Arthritis Rheum , vol.44 , pp. 666-675
    • Gayraud, M.1    Guillevin, L.2    Le Toumelin, P.3
  • 43
    • 1442350027 scopus 로고    scopus 로고
    • Maintenance of remission with leflunomide in Wegener's granulomatosis
    • Metzler C, Fink C, Lamprecht P, et al. Maintenance of remission with leflunomide in Wegener's granulomatosis. Rheumatology (Oxford) 2004;43:315-20.
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 315-320
    • Metzler, C.1    Fink, C.2    Lamprecht, P.3
  • 44
    • 0037097601 scopus 로고    scopus 로고
    • High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate
    • Reinhold-Keller E, Fink CO, Herlyn K, et al. High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate. Arthritis Rheum 2002;47:326-32.
    • (2002) Arthritis Rheum , vol.47 , pp. 326-332
    • Reinhold-Keller, E.1    Fink, C.O.2    Herlyn, K.3
  • 45
    • 0344549857 scopus 로고    scopus 로고
    • Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: A pilot study in 11 patients with renal involvement
    • Nowack R, Göbel U, Klooker P, et al. Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: a pilot study in 11 patients with renal involvement. J Am Soc Nephrol 1999;10:1965-71.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1965-1971
    • Nowack, R.1    Göbel, U.2    Klooker, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.