4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke

Cancer Epidemiology Biomarkers and Prevention

Volumn 15, Issue 5, 2006, Pages 988-992

  Hecht, Stephen S ^a,b   Carmella, Steven G ^a   Le, Ky Anh ^a   Murphy, Sharon E ^a   Boettcher, Angela J ^a   Le, Chap ^a   Koopmeiners, Joseph ^a   An, Larry ^a   Hennrikus, Deborah J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; COTININE; GLUCURONIDE; NICOTINE; TOBACCO SMOKE;

ARTICLE; CARCINOGENESIS; CIGARETTE SMOKING; DEMOGRAPHY; ETHNOLOGY; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; URINE;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COTININE; CREATININE; FEMALE; GLUCURONIDES; HUMANS; INFANT; MALE; MOTHERS; NICOTINE; NITROSAMINES; STATISTICS, NONPARAMETRIC; TOBACCO SMOKE POLLUTION;

EID: 33744771339     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-05-0596     Document Type: Article

References (32)

1. IARC. Tobacco smoke and involuntary smoking. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 83. Lyon (France): IARC; 2004. p. 1191-413.
2. U.S. Department of Health and Human Services. The health consequences of involuntary smoking: a report of the Surgeon General. Department of Health and Human Services publication no. (PHS)87-8398. Washington (District of Columbia): Department of Health and Human Services, Public Health Service, Office of the Assistant Secretary for Health, Office of Smoking and Health; 1986.
3. Environmental Protection Agency. Respiratory health effects of passive smoking: lung cancer and other disorders. Washington (District of Columbia): Office of Health and Environmental Assessment and Office of Research and Development; 1992.
4. National Cancer Institute. Health effects of exposure to environmental tobacco smoke: the report of the California Environmental Protection Agency. Smoking and tobacco control monograph no. 10. NIH publication no. 99-4645. Bethesda (Maryland): U.S. Department of Health and Human Services, NIH, National Cancer Institute; 1999.
5. National Research Council. Environmental tobacco smoke: measuring exposures and assessing health effects. Washington (District of Columbia): National Academy Press; 1986.
6. Boffetta P, Trédaniel J, Greco A. Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: a meta-analysis. Environ Health Perspect 2000;108:73-82.
7. Hecht SS. Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke. Tob Control 2003;13:i48-56.
8. Anderson KE, Kliris J, Murphy L, et al. Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons. Cancer Epidemiol Biomarkers Prev 2003;12:1544-6.
9. Tulunay O, Hecht SS, Carmella SG, et al. Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers. Cancer Epidemiol Biomarkers Prev 2005;14:1283-6.
10. Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 1998;11:559-603.
11. IARC. Smokeless tobacco and tobacco-specific nitrosamines. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 89. Lyon (France): IARC; In press 2006.
12. Hecht SS, Ye M, Carmella SG, et al. Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. Cancer Epidemiol Biomarkers Prev 2001;10:1109-16.
13. Lackmann GM, Salzberger U, Tollner U, et al. Metabolites of a tobacco-specific carcinogen in the urine of newborns. J Natl Cancer Inst 1999;91:459-65.
14. Stepanov I, et al. Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyi)-1-butanone by Moldovan children. Cancer Epidemiol Biomarkers Prev 2006;15:7-11.
15. Zakarian JM, Hovell MF, Sandweiss RD, et al. Behavioral counseling for reducing children's ETS exposure: implementation in community clinics. Nicotine Tob Res 2004;6:1061-74.
16. Hecht SS, Carmella SG, Chen M, et al. Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. Cancer Res 1999;59:590-6.
17. Carmella SG, Han S, Fristad A, et al. Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. Cancer Epidemiol Biomarkers Prev 2003;12:1257-61.
18. Carmella SG, Han S, Villalta PW, et al. Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers' blood. Cancer Epidemiol Biomarkers Prev 2006;14:2669-72.
19. Anderson LM, Hecht SS, Kovatch RM, et al. Tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in infant mice. Cancer Lett 1991;58:177-81.
20. Jalas J, Hecht SS, Murphy SE. Cytochrome P450 2A enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen. Chem Res Toxicol 2005;18:95-110.
21. Hukkanen J, Jacob P III, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 2005;57:79-115.
22. Lee PN. Uses and abuses of cotinine as a marker of tobacco smoke exposure. In: Gorrod JW, Jacob P III, editors. Analytical determination of nicotine and related compounds and their metabolites. Amsterdam: Elsevier; 1999. p. 669-719.
23. Marbury MC, Hammond SK, Haley NJ. Measuring exposure to environmental tobacco smoke in studies of acute health effects. Am J Epidemiol 1993;137:1089-97.
24. Rylander E, Pershagen G, Eriksson M, et al. Parental smoking, urinary cotinine, and wheezing bronchitis in children. Epidemiology 1995;6:289-93.
25. Bakoula CG, Kafritsa YJ, Kavadias GD, et al. Factors modifying exposure to environmental tobacco smoke in children (Athens, Greece). Cancer Causes Control 1997;8:73-6.
26. Peterson EL, Johnson CC, Ownby DR. Use of urinary cotinine and questionnaires in the evaluation of infant exposure to tobacco smoke in epidemiologic studies. J Clin Epidemiol 1997;50:917-23.
27. Klerman L. Protecting children: reducing their environmental tobacco smoke exposure. Nicotine Tob Res 2004;6 Suppl 2:5239-53.
28. Matt GE, Quintana PJ, Hovell MF, et al. Households contaminated by environmental tobacco smoke: sources of infant exposures. Tob Control 2004;13:29-37.
29. Tanski SE, Klein JD, Winickoff JP, et al. Tobacco counseling at well-child and tobacco-influenced illness visits: opportunities for improvement. Pediatrics 2003;111:E162-7.
30. Milunsky A, Carmella SG, Ye M, et al. A tobacco-specific carcinogen in the fetus. Prenat Diagn 2000;20:307-10.
31. Anderson KE, Carmella SG, Ye M, et al. Metabolites of a tobacco-specific lung carcinogen in the urine of nonsmoking women exposed to environmental tobacco smoke in their homes. J Natl Cancer Inst 2001;93:378-81.
32. Parsons WD, Carmella SG, Akerkar S, et al. A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the urine of hospital workers exposed to environmental tobacco smoke. Cancer Epidemiol Biomarkers Prev 1998;7:257-60.