Leachables from saline-containing IV bags can alter therapeutic protein properties

Pharmaceutical Research

Volumn 27, Issue 11, 2010, Pages 2402-2413

  Chang, Judy Y ^a   Xiao, Nina J ^a   Zhu, Min ^a   Zhang, Jennifer ^a   Hoff, Ed ^a   Russell, Stephen J ^a   Katta, Viswanatham ^a   Shire, Steven J ^a  

^a GENENTECH INC   (United States)

Author keywords

compatibility; dulanermin; freeze and thawing; IV infusion bags; leachables

Indexed keywords

2 MERCAPTOBENZOTHIAZOLE; ANTINEOPLASTIC AGENT; DULANERMIN; MONOMER; POLYOLEFIN; POLYVINYLCHLORIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INCOMPATIBILITY; DRUG MANUFACTURE; DRUG STABILITY; FREEZE THAWING; GEL PERMEATION CHROMATOGRAPHY; LEACHING; LIGHT ABSORPTION; LIQUID CHROMATOGRAPHY; MATERIALS TESTING; METAL EXTRACTION; OPTICAL RESOLUTION; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INFUSIONS, INTRAVENOUS; MASS SPECTROMETRY; PROTEINS; SODIUM CHLORIDE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 78549251371     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0193-8     Document Type: Article

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