Confirmation of association between multiple sclerosis and CYP27B1

European Journal of Human Genetics

Volumn 18, Issue 12, 2010, Pages 1349-1352

  Sundqvist, Emilie ^a   Bäärnhielm, Maria ^a   Alfredsson, Lars ^a   Hillert, Jan ^a   Olsson, Tomas ^a   Kockum, Ingrid ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

association study; case control study; CYP27B1; meta analysis; multiple sclerosis; vitamin D

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 27B1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN; VITAMIN METABOLISM;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ALLELES; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MULTIPLE SCLEROSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; SWEDEN;

EID: 78549234005     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.113     Document Type: Article

References (25)

1. Kurtzke JF: Epidemiology of multiple sclerosis. Does this really point toward an etiology? Lectio Doctoralis. Neurol Sci 2000; 21: 383-403.
2. Acheson ED, Bachrach CA, Wright FM: Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation, and other variables. Acta Psychiatr Scand 1960; 35 (Suppl): 132-147.
3. van der Mei IA, Ponsonby AL, Blizzard L, Dwyer T: Regional variation in multiple sclerosis prevalence in Australia and its association with ambient ultraviolet radiation. Neuroepidemiology 2001; 20: 168-174.
4. Willer CJ, Dyment DA, Sadovnick AD, Rothwell PM, Murray TJ, Ebers GC: Canadian Collaborative Study Group. Timing of birth and risk of multiple sclerosis: population based study. BMJ 2005; 330: 120.
5. Bayes HK, Weir CJ, O'Leary C: Timing of birth and risk of multiple sclerosis in the Scottish population. Eur Neurol 2010; 63: 36-40.
6. Australian and New Zealand Multiple Sclerosis Genetics Consortium: Genome-wide association study identifies new multiple sclerosis loci on chromosomes 12 and 20. Nat Genet 2009; 41: 824-830.
7. Bailey R, Cooper JD, Zeitels L et al: Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 2007; 56: 2616-2621.
8. Lopez ER, Regulla K, Pani MA, Krause M, Usadel KH, Badenhoop K: CYP27B1 polymorphisms variants are associated with type 1 diabetes mellitus in Germans. J Steroid Biochem Mol Biol 2004; 89-90: 115-157.
9. Lopez ER, Zwermann O, Segni M et al: A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. (B) Eur J Endocrinol 2004; 151: 193-197.
10. Orton SM, Morris AP, Herrera BM et al: Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis. Am J Clin Nutr 2008; 88: 441-447.
11. Smolders J, Damoiseaux J, Manheere P, Hupperts R: Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol 2008; 194: 7-17.
12. Gorman S, Kuritzky LA, Judge MA et al: Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J Immunol 2007; 179: 6273-6283.
13. van Etten E, Stoffels K, Gysemans C, Mathieu C, Overbergh L: Regulation of vitamin D homeostasis: implications for the immune system. Nutr Rev 2008; 66 (Suppl 2): S125-S134.
14. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A: Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296: 2832-2838.
15. Smolders J, Thewissen M, Peelen E et al: Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One 2009; 4: e6635.
16. Roos IM, Kockum I, Hillert J: The interleukin 23 receptor gene in multiple sclerosis: a case-control study. J Neuroimmunol 2008; 194: 173-180.
17. Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L: Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Neurology 2009; 73: 696-701.
18. de Bakker PI, Yelensky R, Péer I, Gabriel SB, Daly MJ, Altshuler D: Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217-1223.
19. Ekelund E, Saaf A, Tengvall-Linder M et al: Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis. Am J Hum Genet 2006; 78: 1060-1065.
20. Li Y, Abecasis GR: Mach 1.0: rapid haplotyoe reconstruction and missing genotype inference. Am J Hum Genet 2006; S79: 416.
21. Dudbridge F: Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008; 66: 87-98.
22. Lange EM, Sun J, Lange LA et al: Family-based samples can play an important role in genetic association studies. Cancer Epidemiol Biomarkers Prev 2008; 17: 2208-2214.
23. van der Mei IA, Ponsonby AL, Dwyer T et al: Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. J Neurol 2007; 254: 581-590.
24. Ramos-Lopez E, Brück P, Jansen T, Pfeilschifter JM, Radeke HH, Badenhoop K: CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol 2007; 103: 807-810.
25. Ramagopalan SV, Maugeri NJ, Handunnetthi L et al: Expression of the multiple sclerosis-associated MHC class II allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet 2009; 5: e1000369.