Safety and pharmacokinetic analysis of methotrexate administered directly into the fourth ventricle in a piglet model

Journal of Neuro-Oncology

Volumn 100, Issue 3, 2010, Pages 397-406

  Sandberg, David I ^a   Solano, Juan ^a   Petito, Carol K ^a   Mian, Abdul ^a   Mou, Caihong ^a   Koru Sengul, Tulay ^a   Gonzalez Brito, Manuel ^a   Padgett, Kyle R ^a   Luqman, Ali ^a   Buitrago, Juan Carlos ^a   Alam, Farid ^a   Wilkerson, Jerome R ^a   Crandall, Kenneth M ^a   Kuluz, John W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotherapy; Fourth ventricle; Intraventricular; Local delivery; Piglet

Indexed keywords

CD3 ANTIGEN; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN FOURTH VENTRICLE; BRAIN NECROSIS; BRAIN STEM; BRAIN VENTRICLE DILATATION; CD3+ T LYMPHOCYTE; CEREBELLUM; CHOROID PLEXUS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG SAFETY; HISTOPATHOLOGY; MENINGITIS; NONHUMAN; PIGLET;

ANIMALS; AREA UNDER CURVE; CELL COUNT; ENZYME INHIBITORS; FOURTH VENTRICLE; MAGNETIC RESONANCE IMAGING; METHOTREXATE; MODELS, ANIMAL; SWINE; TIME FACTORS;

EID: 78449305285     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0210-0     Document Type: Article

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