Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

Cancer Chemotherapy and Pharmacology

Volumn 45, Issue 3, 2000, Pages 259-264

  Balis, Frank M ^a   Blaney, Susan M ^a   McCully, Cynthia L ^a   Bacher, John D ^b   Murphy, Robert F ^a   Poplack, David G ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid; Intrathecal; Methotrexate; Pharmacokinetics

Indexed keywords

METHOTREXATE; PROBENECID;

ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG TRANSPORT; INJECTION SITE; LATERAL BRAIN VENTRICLE; MACACA; MALE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; SUBARACHNOID SPACE;

EID: 0033982464     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050038     Document Type: Article

References (21)

1. 2 in rhesus monkeys. J Clin Oncol 10: 1359
2. 2. Bacher JD, Balis FM, McCully CM, Godwin K (1994) Cerebral subarachnoid sampling of cerebrospinal fluid in the rhesus monkey. Lab Anim Sci 44: 148
3. 3. Balis F, Poplack D (1989) Central nervous system pharmacology of antileukemia drugs. Am J Pediatr Hematol Oncol 11: 74
4. 4. Bauer JD, Ackerman JD, Toro G (1968) Bray's clinical laboratory methods. Mosby, St. Louis
5. 5. Blaney SM, Daniel MJ, Harker AJ, Godwin K, Balis FM (1995) Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates. Anti-microb Agents Chemother 39: 2779
6. 6. Blasberg RG, Patlak CS, Shapiro WR (1977) Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration. Cancer Treat Rep 61: 633
7. 7. Bleyer WA, Dedrick RL (1977) Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection. Cancer Treat Rep 61: 703
8. 8. Bleyer W, Poplack D (1978) Clinical studies on the central-nervous-system pharmacology of methotrexate. In: Pinedo H (ed) Clinical pharmacology of anti-neoplastic drugs. Elsevier/ North-Holland Biomedica, Amsterdam, p 115
9. 9. Bleyer WA, Poplack DG (1979) Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. Med Pediatr Oncol 6: 207
10. 10. Bleyer WA, Poplack DG, Simon RM, Henderson ES, Leventhal BG, Zigler JL, Levine AS, Ommaya AK (1978) "Concentration × time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms. Blood 51: 835
11. 11. Iacoangeli M, Roselli R, Pagano L, Leone G, Marra R, Pompucci A, Trignani R, Scerrati M (1995) Intrathecal chemotherapy for treatment of overt meningeal leukemia: comparison between intraventricular and traditional intralumbar route. Ann Oncol 6: 377
12. 12. Kessler JA, Fenstermacher JD, Owens ES (1976) Spinal subarachnoid perfusion of rhesus monkeys. Am J Physiol 230: 614
13. 13. Margolin JF, Poplack DG (1997) Acute lymphoblastic leukemia. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. Lippincott, Philadelphia, p 409
14. 14. McCully CL, Balis FM, Bacher J, Phillips J, Poplack DG (1990) A rhesus monkey model for continuous infusion of drugs into cerebrospinal fluid. Lab Anim Sci 40: 250
15. 15. Miller KT, Wilkinson DS (1989) Pharmacokinetics of methotrexate in the cerebrospinal fluid after intracerebroventricular administration in patients with meningeal carcinomatosis and altered cerebrospinal fluid flow dynamics. Ther Drug Monit 11: 231
16. 16. National Research Council (1996) Guide for the care and use of laboratory animals. National Academy Press, Washington DC
17. 17. Ommaya AK (1984) Implantable devices for chronic access and drug delivery to the central nervous system. Cancer Drug Deliv 1: 169
18. 18. Patel M, Blaney SM, Balis FM (1998) Pharmacokinetics of drug delivery to the central nervous system. In: Growchow LB, Ames MM (eds) A clinician's guide to chemotherapy pharmacokinetics and pharmacodynamics. Williams & Wilkins, Philadelphia, p 67
19. 19. Rubin R, Owens E, Rall D (1968) Transport of methotrexate by the choroid plexus. Cancer Res 28: 689
20. 20. Shapiro WR, Young DF, Mehta BM (1975) Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. N Engl J Med 293: 161
21. 21. Spector R (1976) Inhibition of MTX transport from CSF by probenicid. Cancer Treat Rep 60: 913