In vivo inhibition of epidermal growth factor receptor autophosphorylation prevents receptor internalization

Experimental Cell Research

Volumn 317, Issue 1, 2011, Pages 42-50

  Wolff, Michael ^a   Tetzlaff, Kay ^b   Nivens, Michael C ^b   Schneider, Franz Josef ^a   Jung, Birgit ^a   Hohlfeld, Jens ^c   Heilker, Ralf ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Autophosphorylation; Epidermal growth factor receptor; Fluorescence microscopy; Image analysis; Internalization

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BIBW 2948 BS; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; MUCIN; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOPHOSPHORYLATION; BRONCHOSCOPY; BRONCHUS BIOPSY; CELL STRAIN; CELL STRAIN NCI H 292; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; IMAGE ANALYSIS; INTERNALIZATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN DOMAIN; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY EPITHELIUM;

EID: 78449298390     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.09.009     Document Type: Article

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