Preventing post traumatic stress disorder: Are drugs the answer?

Australian and New Zealand Journal of Psychiatry

Volumn 44, Issue 12, 2010, Pages 1064-1071

  Fletcher, Susan ^a   Creamer, Mark ^a   Forbes, David ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

pharmacotherapy; prevention; PTSD

Indexed keywords

ALCOHOL; GABAPENTIN; HYDROCORTISONE; MORPHINE; PLACEBO; PROPRANOLOL;

ALCOHOL CONSUMPTION; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; HEART SURGERY; HUMAN; INFORMATION PROCESSING; MEDLINE; POSTTRAUMATIC STRESS DISORDER; PSYCHOPHARMACOTHERAPY; REVIEW; TRAFFIC ACCIDENT;

ANTI-ANXIETY AGENTS; ETHANOL; HUMANS; HYDROCORTISONE; MORPHINE; PROPRANOLOL; STRESS DISORDERS, POST-TRAUMATIC;

EID: 78449291923     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.3109/00048674.2010.509858     Document Type: Review

References (53)

1. Oxford English Dictionary. Available from URL: http://dictionary.oed.com [cited January 2009].
2. Alexander DA, Wells A. Reactions of police officers to body-handling after a major disaster: a before-and-after comparison. Br J Psychiatry 1991; 159:547-555.
3. Paton D. Disaster relief work: an assessment of training effectiveness. J Trauma Stress 1994; 7:275-288.
4. Creamer M, Burgess P, McFarlane AC. Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-Being. Psychol Med 2001; 31:1237-1247.
5. Norris FH, Stevens S P. Community resilience and the principles of mass trauma intervention. Psychiatry 2007; 70:320-328.
6. Kessler RC, Sonnega A, Hughes M, Nelson CB. Posttraumatic stress disorder in the national comorbidity survey. Arch Gen Psychiatry 1995; 52:1048-1060.
7. Kessler RC, Angermeyer M, Anthony JC et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry 2007; 6:168-176.
8. Bradley R, Greene J, Russ E, Dutra L, Westen D. A multidimensional meta-analysis of psychotherapy for PTSD. Am J Psychiatry 2005; 162:214-227.
9. Pitman RK, Delahanty DL. Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr 2005; 10:99-106.
10. McFarlane AC. Epidemiological evidence about the relationship between PTSD and alcohol abuse: the nature of the association. Addict Behav 1998; 23:813-825.
11. Maes M, Delmeire L, Mylle J, Altamura C. Risk and preventive factors of posttraumatic stress disorder (PTSD): alcohol consumption and intoxication prior to a traumatic event diminishes the relative risk to develop PTSD in response to trauma. J Affect Disord 2001; 63:113-121.
12. Mellman TA, Ramos J, David D, Williams L, Augenstein JS. Possible inhibition of early PTSD symptoms by alcohol intoxication [Letter]. Depress Anxiety 1998; 7:145.
13. Sayette MA. Does drinking reduce stress? Alcohol Res Health 1999; 23:250-255.
14. Clum GA, Nishith P, Calhoun KS. A preliminary investigation of alcohol use during trauma and peritraumatic reactions in female sexual assault victims. J Trauma Stress 2002; 15:321-328.
15. Simon A, Gorman J. Psychopharmacological possibilities in the acute disaster setting. Psychiatr Clin North Am 2004; 27:425-458.
16. World Health Organization. The global burden of disease: 2004 update. Geneva: World Health Organization, 2008.
17. Yehuda R. Risk and resilience in posttraumatic stress disorder. J Clin Psychiatry 2004; 65:29-36.
18. Ehring T, Ehlers A, Cleare AJ, Glucksman E. Do acute psychological and psychobiological responses to trauma predict subsequent symptom severities of PTSD and depression? Psychiatry Res 2008; 161:67-75.
19. McFarlane AC, Atchison M, Yehuda R. The acute stress response following motor vehicle accidents and its relation to PTSD. Ann N Y Acad Sci 1997; 821:437-441.
20. Schelling G, Briegel J, Roozendaal B, Stoll C, Rothenhausler HB, Kapfhammer H P. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry 2001; 50:978-985.
21. Schelling G, Kilger E, Roozendaal B et al. Stress doses of hydro-cortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Biol Psychiatry 2004; 55:627-633.
22. Weis F, Kilger E, Roozendaal B et al. Stress doses of hydrocorti-sone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized study. J Thorac Cardiovasc Surg 2006; 131:277-282.
23. Pitman RK, Sanders KM, Zusman RM et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry 2002; 51:189-192.
24. Bryant RA, Creamer M, O'Donnell M, Silove D, McFarlane AC. A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder. Biol Psychiatry 2009; 65:438-440.
25. Henry M, Fishman JR, Youngner SJ. Propranolol and the prevention of post-traumatic stress disorder: is it wrong to erase the ' sting'of bad memories? Am J Bioeth 2007; 7:12-20.
26. McCleery JM, Harvey AG. Integration of psychological and biological approaches to trauma memory: implications for pharmacological prevention of PTSD. J Trauma Stress 2004; 17:485-496.
27. Holbrook TL, Galarneau MR, Dye JL, Quinn K, Dougherty AL. Morphine use after combat injury in Iraq and post-traumatic stress disorder. New Engl J Med 2010; 362:110-117.
28. Saxe G, Stoddard F, Courtney D et al. Relationship between acute morphine and the course of PTSD in children with burns. J Am Acad Child Adolesc Psychiatr 2001; 40:915-921.
29. Stoddard FJ, Sorrentino EA, Ceranoglu TA et al. Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one-to four-year-olds with burns. J Burn Care Res 2009; 30:836-843.
30. Saxe G, Geary M, Bedard K et al. Separation anxiety as a mediator between acute morphine administration and PTSD symptoms in injured children. Ann N Y Acad Sci 2006; 1071:41-45.
31. Vaiva G, Ducrocq F, Jezequel K et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiatry 2003; 54:947-949.
32. McGhee LL, Maani C V, Garza TH, DeSocio PA, Gaylord KM, Black IH. The effect of propranolol on posttraumatic stress disorder in burned service members. J Burn Care Res 2009; 30:92-97.
33. Stein MB, Kerridge C, Dimsdale JE, Hoyt DB. Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress 2007; 20:923-932.
34. Shin LM, Handwerger K. Is posttraumatic stress disorder a stress-induced fear circuitry disorder? J Trauma Stress 2009; 22:409-415.
35. Kabasenche W. Emotions, memory suppression, and identity. Am J Bioeth 2007; 7:33-34.
36. President's Council on Bioethics. Beyond therapy: biotechnology and the pursuit of happiness. Washington, DC: Government Printing Office, 2003.
37. Liao SM, Wasserman DT. Neuroethical concerns about moderating traumatic memories. Am J Bioeth 2007; 7:38-40.
38. Hurley EA. The moral costs of prophylactic propranolol. Am J Bioeth 2007; 7:35-36.
39. Craigie J. Propranolol, cognitive biases, and practical decision-making. Am J Bioeth 2007; 7:31-32.
40. Corwin JE, Peselow E, Feenan K, Rotrosen J, Fieve R. Disorders of decision in affective disease: an effect of β-adrenergic dysfunction? Biol Psychiatry 1990; 27:813-833.
41. Rogers RD, Lancaster M, Wakeley J, Bhagwagar Z. Effects of beta-adrenoceptor blockade on components of human decision-making. Psychopharmacology 2004; 163:202-212.
42. Hall W, Carter A. Debunking alarmist objections to the pharmacological prevention of PTSD. Am J Bioeth 2007; 7:23-25.
43. Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol 2000; 68:748-766.
44. Ozer EJ, Best SR, Lipsey TL, Weiss DS. Predictors of posttrau-matic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull 2003; 129:52-73.
45. Norman SB, Stein MB, Dimsdale JE, Hoyt DB. Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder. Psychol Med 2008; 38:533-542.
46. Shalev AY, Sahar T, Freedman S et al. A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. Arch Gen Psychiatry 1998; 55: 553-559.
47. Bryant RA, Harvey AG, Guthrie RM, Moulds ML. A prospective study of psychophysiological arousal, acute stress disorder, and posttraumatic stress disorder.J Abnorm Psychol 2000; 109: 341-344.
48. O'Donnell ML, Creamer MC, Parslow R et al. A predictive screening index for posttraumatic stress disorder and depression following traumatic injury. J Consult Clin Psychol 2008; 76:923-932.
49. Kessler RC. Social anxiety and PTSD: from stress to avoidance. Eur Neuropsychopharmacol 2000; 10:185-186.
50. van Stegeren AH, Goekoop R, Everaerd W et al. Noradrenaline mediates amygdala activation in men and women during encoding of emotional material. Neuroimage 2005; 24:898-909.
51. Buchanan T W, Lovallo WR. Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology 2001; 26:307-317.
52. Tenenbaum EM, Reese B. Memory-altering drugs: shifting the paradigm of informed consent. Am J Bioeth 2007; 7:40-42.
53. Zatzick D, Roy-Byrne P P. From bedside to bench: how the epidemiology of clinical practice can inform the secondary prevention of PTSD. Psychiatr Serv 2006; 57:1726-1730.