Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients

Aging Male

Volumn 13, Issue 4, 2010, Pages 242-246

  Amano, Toshiyasu ^a   Imao, Tetsuya ^a   Takemae, Katsurou ^a   Iwamoto, Teruaki ^b   Nakanome, Mariko ^c  

^a NAGANO RED CROSS HOSPITAL   (Japan)

^b INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

late onset hypogonadism; lower urinary tract symptoms; Testosterone ointment

Indexed keywords

GLOWMIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HORMONE SUBSTITUTION; HUMAN; HYPOGONADISM; INTERNATIONAL INDEX OF ERECTILE FUNCTION; INTERNATIONAL PROSTATE SYMPTOM SCORE; LATE ONSET HYPOGONADISM; LOWER URINARY TRACT SYMPTOM; MALE; MICTURITION; MORNING DOSAGE; PRIORITY JOURNAL; SHORT FORM 36; TESTOSTERONE BLOOD LEVEL;

ADULT; AGE OF ONSET; AGED; DRUG DOSAGE CALCULATIONS; GENITALIA, MALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOGONADISM; JAPAN; MALE; MIDDLE AGED; OINTMENTS; PENILE ERECTION; PILOT PROJECTS; PROSTATE; SICKNESS IMPACT PROFILE; TESTOSTERONE; TREATMENT OUTCOME;

EID: 78449276046     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2010.487552     Document Type: Article

References (38)

1. Nieschlag E, Swerdloff R, Behre HM, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morley JE, Schulman C, Wang C, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male 2005;8:56-58.
2. Morales A, Tenover JL. Androgen deficiency in the aging male: when, who, and how to investigate and treat. Urol Clin N Am 2002;29:975-982.
3. Lunenfeld B, Saad F, Hoesl CE. ISA, ISSAM and EAU recommendations for the investigation, treatment and monitoring of late-onset hypogonadism in males: scientific background and rationale. Aging Male 2005;8:59-74.
4. Lunenfeld B, Nieschlag E. Testosterone therapy in the aging male. Aging Male 2007;10:139-153.
5. Wang CM, Nieschlag E, Swerdloff RS, Behre H, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, et al. ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male 2009;12:5-12.
6. Amano T, Imao T, Takemae K, Iwamoto T, Yamakawa K, Baba K, Nakanome M, Sugimori H, Tanaka T, Yoshida K, et al. Profile of serum testosterone levels after application of testosterone ointment (Glowmin) and its clinical efficacy in late-onset hypogonadism patients. J Sex Med 2008;5:1727-1736.
7. Shiri R, Hakkinen JT, Hakama M, Huhtala H, Auvinen A, Tammela TL. Koskimaki J. Effect of lower urinary tract symptoms on the incidence of erectile dysfunction. J Urol 2005;174:205-209.
8. El-Sakka AI. Lower urinary tract symptoms in patients with erectile dysfunction: analysis of risk factors. J Sex Med 2006;3:144-149.
9. Rhoden EL, Riedner CE, Fornari A, Fuchs SC, Ribeiro ER. Evaluation of the association between lower urinary tract symptoms and erectile dysfunction, considering its multiple risk factors. J Sex Med 2008;5:2662-2668.
10. Morant S, Bloomfield G, Vats V, Chapple C. Increased sexual dysfunction in men with storage and voiding lower urinary tract symptoms. J Sex Med 2009;6:1103-1110.
11. Mariappan P, Chong WL. Prevalence and correlations of lower urinary tract symptoms, erectile dysfunction and incontinence in men from a multiethnic Asian population: Results of a regional population-based survey and comparison with industrialized nations. BJU Int 2006;98:1264-1268.
12. Amano T, Imao T, Takemae K. Lower urinary tract symptom in patients with late-onset hypogonadism. Jpn J Impotence Res 2009;24:359-365.
13. Japan Urological Association/Japan Men's Health Medical Association. Clinical guideline for late-onset hypogonadism (LOH). Tokyo, Japan: KK Jiho; 2007. pp 2-28.
14. Heinemann LAJ, Zimmermann T, Vermeulen A, Thiel C, Hummel. A new 'aging males' symptoms' rating scale. Aging Male 1999;2:105-114.
15. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM. Development and evaluation of an abridged, 5-item version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319-326.
16. Fukuhara S, Ware JE, Kosinski M, Wada S, Gandek B. Psychometric and clinical tests of validity of the Japanese SF-36 Healthy Survey. J Clin Epidemiol 1998;51:1045-1053.
17. Karazindiyanoglu S, Cayan S. The effect of testosterone therapy on lower urinary tract symptoms/bladder and sexual functions in men with symptomatic late-onset hypogonadism. Aging Male 2008;11:146-149.
18. Kalinchenko S, Vishnevsky EL, Koval AN, Mskhalaya GJ, Saad F. Beneficial effects of testosterone administration on symptoms of the lower urinary tract in men with late-onset hypogonadism: a pilot study. Aging Male 2008;11:57-61.
19. Haider A, Gooren LJ, Padungtod P, Saad F. Concurrent improvement of the metabolic syndrome and lower urinary tract symptoms upon normalization of plasma testosterone levels in hypogonadal elderly men. Andrologia 2009;41:7-13.
20. Takao T, Tsujimura A, Nakayama J, Matsuoka M, Miyagawa Y, Takada S, Nonomura N, Okuyama A. Lower urinary tract symptoms after hormone replacement therapy in Japanese patients with late-onset hypogonadism: a preliminary report. Int J Urol 2009;16:212-214.
21. McVary K. Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology. BJU Int 2006;97 (suppl 2):23-28.
22. Tinel H, Stelte-Ludwig B, Hutter J, Sandner P. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. BJI Int 2006;98:1259-1263.
23. Matsumoto S, Hanai T, Uemura H, Levin RM. Effects of chronic treatment with Vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model. BJU Int 2009;103:987-990.
24. Sairam K, Kulinskaya E, Mcnicholas TA, Boustead GB, Hanbury DC. Sildenafil influences lower urinary tract symptoms. BJU Int 2002;90:836-839.
25. Mulhall JP, Guhring P, Parker M, Hopps C. Assessment of the impact of sildenafil citrate on lower urinary tract symptoms in men with erectile dysfunction. J Sex Med 2006;3:662-667.
26. Gacci M, Del Popolo G, Macchiarella A, Celso M, Vittori G, Lapini A, Serni S, Sandner P, Maggi M, Carini M. Vardenafil improves urodynamic parameters in men with spinal cord injury: results from a single dose, pilot study. J Urol 2007;178:2040-2044.
27. McVary KT, Roehrborn CG, Kaminetsky JC, Auerbach SM, Wachs B, Young JM, Esler A, Sides GD, Denes BS. Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 2007;177:1401-1407.
28. Liguori G, Trombetta C, De Giorgi G, Pomara G, Maio G, Vecchio D, Ocello G, Ollandini G, Bucci S, Belgrano E. Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: an integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report. J Sex Med 2009; 6:544-552.
29. Yassin AA, El-Sakka AI, Saad F, Gooren LJG. Lower urinary-tract symptoms and testosterone in elderly men. World J Urol 2008;26:359-364.
30. Irwin DE, Milsom I, Reilly K, Hunskaar S, Kopp Z, Herschom S, Coyne KS, Kelleher CJ, Artibani W, Abrams P. Overactive bladder is associated with erectile dysfunction and reduced sexual quality of life in men. J Sex Med 2008;5:2904-2910.
31. Braun MH, Sommer F, Haupt G, Mathers MJ, Reifenrath B, Engelmann UH. Lower urinary tract symptoms and erectile dysfunction: co-morbidity or typical "Aging Male" symptoms? Results of the "Cologne Male Survey". Eur Urol 2003;44:588-594.
32. Ponholzer A, Temml C, Obermayr R, Madersbacher S. Association between lower urinary tract symptoms and erectile dysfunction. Urology 2004;64:772-776.
33. Frankel SJ, Donovan JL, Peters TI, Abrams P, Dabhoiwala NF, Osawa D, Lin AT. Sexual dysfunction in men with lower urinary tract symptoms. J Clin Epidemiol 1998;51:677-685.
34. Aslan G, Cavus E, Karas H, Oner O, Duran F, Esen A. Association between lower urinary tract symptoms and erectile dysfunction. Arch Androl 2006;52:155-162.
35. Leliefeld HH, Stoevelaar HJ, McDonnell J. Sexual function before and after various treatments for symptomatic benign prostate hyperplasia. BJU Int 2002;89:208-213.
36. Shabsigh R, Crawford ED, Nehra A, Slawin KM. Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review. Int J Impot Res 2009;21:9-23.
37. Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992;75:1092-1098.
38. Holmang S, Marin P, Lindstedt G, Hedelin H. Effect of long-term oral testosterone undecanoate treatment on prostate volume and serum prostate-specific antigen concentration in eugonadal middle-aged men. Prostate 1993;23:99-106.