Effects of chronic treatment with vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model

BJU International

Volumn 103, Issue 7, 2009, Pages 987-990

  Matsumoto, Seiji ^a,b   Hanai, Tadashi ^a,b   Uemura, Hirotsugu ^b   Levin, Robert M ^c  

^a Koushinkai Hospital   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Bladder outlet obstruction; Lower urinary tract symptoms; PDE5 inhibitor; Vardenafil

Indexed keywords

CARBACHOL; DRINKING WATER; PHOSPHODIESTERASE V INHIBITOR; POTASSIUM CHLORIDE; VARDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER NECK STENOSIS; BLADDER SURGERY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MEGADOSE; ELECTROSTIMULATION; FEMALE; LOWER URINARY TRACT SYMPTOM; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RAT; SPRAGUE DAWLEY RAT; TISSUE SECTION;

ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; IMIDAZOLES; MUSCLE CONTRACTION; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; TRIAZINES; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION;

EID: 62149108511     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.08185.x     Document Type: Article

References (16)

1. Sairam K, Kulinskaya E, McNicholas TA, Boustead GB, Hanbury DC. Sildenafil influences lower urinary tract symptoms. BJU Int 2002 90 : 836 9
2. Tinel H, Stelte-Ludwig B, Hutter J, Sandner P. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. BJU Int 2006 98 : 1259 63
3. McVary KT, Roehrborn CG, Kaminetsky JC et al. Tadalafil relieves lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 2007 177 : 1401 7
4. McVary KT, Monnig W, Camps JL Jr, Young JM, Tseng LJ, van den Ende G. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial. J Urol 2007 177 : 1071 7
5. Gacci M, Del Popolo G, Macchiarella A et al. Vardenafil improves urodynamic parameters in men with spinal cord injury: results from a single dose, pilot study. J Urol 2007 178 : 2040 4
6. Filippi S, Morelli A, Sandner P et al. Characterization and functional role of androgen-dependent PDE5 activity in the bladder. Endocrinology 2007 148 : 1019 29
7. Matsumoto S, Hanai T, Ohnishi N, Yamamoto K, Kurita T. Bladder smooth muscle cell phenotypic changes and implication of expression of contractile proteins (especially caldesmon) in rats after partial outlet obstruction. Int J Urol 2003 10 : 339 45
8. Hanai T, Ma FH, Matsumoto S, Park YC, Kurita T. Partial outlet obstruction of the rat bladder induces a stimulatory response on proliferation of the bladder smooth muscle cells. Int Urol Nephrol 2002 34 : 37 42
9. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease. BJU Int 2006 97 : 625 33
10. Lorenzi B, McMurray G, Jarvis G, Brading AF. Preconditioning protects the guinea-pig urinary bladder against ischaemic conditions in vitro. Neurourol Urodyn 2003 22 : 687 92
11. Guazzi M, Samaja M. The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development. Curr Med Chem 2007 14 : 2181 91
12. Buttyan R, Chen MW, Levin RM. Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction. Eur Urol 1997 32 (Suppl. 1 32 9
13. Whitbeck C, Chichester P, Sokol R, Levin RM. Role of nitric oxide in urinary bladder function: effect of l-arginine. Urol Int 2007 78 : 30 6
14. Lin WY, Levin RM, Chichester P et al. Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Am J Physiol Regul Integr Comp Physiol 2007 293 : 2390 9
15. Werkström V, Lee T, Hedlund P, Andersson KE. Vardenafil Relaxes Precontracted Rat Detrusor Partially through Urothelium-Dependent Mechanisms. EAU 2008 Poster 773.
16. Oger S, Behr-Roussel D, Gorny D, Lebret T, Validire P, Giuliano FA. Signaling Pathways Involved in Sildenafil-Induced Relaxation of Human Detrusor. AUA 2008, Poster 360.