Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7855-7867

  Banerjee, Ashutosh ^a   Schepmann, Dirk ^a   Köhler, Jens ^a   Würthwein, Ernst Ulrich ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

4 Substituted; Dexoxadrol derivatives; DFT calculations; Imino Diels Alder reaction; NMDA receptor antagonists (PCP site); Stereochemistry; Structure affinity relationships

Indexed keywords

2 (2,2 DIPHENYL 1,3 DIOXOLAN 4 YL) 4 FLUOROPIPERIDINE; 2 (2,2 DIPHENYL 1,3 DIOXOLAN 4 YL) 4,4 DIFLUOROPIPERIDINE; DEXOXADROL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; WMS 2539;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; DIELS ALDER REACTION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; BINDING SITES; BRAIN; DIOXOLANES; MODELS, THEORETICAL; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; STATIC ELECTRICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

ALNUS;

EID: 78449248928     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.047     Document Type: Article

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