Pre-clinical assays predict Pan-African Echis viper efficacy for a species-specific antivenom

PLoS Neglected Tropical Diseases

Volumn 4, Issue 10, 2010, Pages

  Casewell, Nicholas R ^a,b   Cook, Darren A N ^a   Wagstaff, Simon C ^a   Nasidi, Abdulsalami ^c   Durfa, Nandul ^c   Wüster, Wolfgang ^b   Harrison, Robert A ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b BANGOR UNIVERSITY   (United Kingdom)

^c Federal Ministry of Health   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

SNAKE VENOM ANTISERUM; NEUTRALIZING ANTIBODY; VENOM ANTISERUM; VIPER VENOM;

AFRICA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; ECHIS CARINATUS SOCHUREKI; ECHIS PYRAMIDUM LEAKEYI; ECHIS VENOM; ENVENOMATION; GEOGRAPHIC ORIGIN; IMMUNIZATION; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; POISONOUS SNAKE; SPECIES DIFFERENCE; AFRICA SOUTH OF THE SAHARA; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SERODIAGNOSIS; SNAKE; SNAKEBITE; SURVIVAL;

AFRICA SOUTH OF THE SAHARA; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIVENINS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; MICE; NEUTRALIZATION TESTS; SNAKE BITES; SURVIVAL ANALYSIS; VIPER VENOMS; VIPERIDAE;

EID: 78449245043     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000851     Document Type: Article

References (35)

1. Harrison RA, Hargreaves A, Wagstaff SC, Faragher B, Lalloo DG (2009) Snake envenoming: a disease of poverty. PLoS Negl Trop Dis 3(12): e569.
2. Kasturiratne A, Wickremasinghe AR, de Silva N, Gunawardena NK, Pathmeswaran A, et al. (2008) The global burden of snakebite: A literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med 5(11): e218.
3. Theakston RDG, Warrell DA (2000) Crisis in snake antivenom supply for Africa. Lancet 356: 2104-2104.
4. Gutiérrez JM, Theakston RDG, Warrell DA (2006) Confronting the neglected problem of snake bite envenoming: The need for a global partnership. PLoS Medicine 3: e150.
5. Stock RP, Massougbodji A, Alagón A, Chippaux J-P (2007) Bringing antivenoms to sub-Saharan Africa. Nature Biotechnology 25: 173-177.
6. Williams D, Gutiérrez JM, Harrison R, Warrell DA, White J, Winkel KD (2010) Viewpoint: an antidote for snake bite. The Global Snake Bite Initiative. Lancet 375: 89-91.
7. Gutiérrez JM, Rojas E, Quesada L, León G, Núñez J, et al. (2005) Pan-African polyspecific antivenom produced by caprilyic acid purification of horse IgG: an alternative to the antivenom crisis in Africa. Trans R Soc Trop Med Hyg 99(6): 468-475.
8. Abubakar SB, Abubakar IS, Habib AG, Nasidi A, Durfa N, et al. (2010) Preclinical and preliminary dose-finding and safety studies to identify candidate antivenoms for treatment of envenoming by saw-scaled or carpet vipers (Echis ocellatus) in northern Nigeria. Toxicon 55: 719-723.
9. Abubakar IS, Abubakar SB, Habib AG, Nasidi A, Durfa N, et al. (2010) Randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (Echis ocellatus) envenoming in Nigeria. PLoS Negl Trop Dis 4(7): e767.
10. Warrell DA, Arnett C (1976) The importance of bites by the saw scaled or carpet viper (Echis carinatus). Epidemiological studies in Nigeria and a review of the world literature. Acta Tropica 33: 307-341.
11. Pugh RN, Theakston RD (1980) Incidence and mortality on snake bite in savanna Nigeria. Lancet 2: 1181-1183.
12. Habib AG, Gebi UI, Onyemelukwe GC (2001) Snake bite in Nigeria. Afr J Med Med Sci 30: 171-178.
13. Warrell DA, Ormerod LD, Davidson NM (1975) Bites by puff-adder (Bitis arietans) in Nigeria, and value of antivenom. Brit Med J 4: 697-700.
14. Warrell DA, Greenwood BM, Davidson NM, Ormerod LD, Prentice CRM (1976) Necrosis, haemorrhage and complement depletion following bites by the spitting cobra (Naja nigricollis). Q J Med 45: 1-22.
15. Casewell NR, Harrison RA, Wüster W, Wagstaff SC (2009) Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts. BMC Genomics 10: 564.
16. Pook CE, Joger U, Stümpel N, Wüster W (2009) When continents collide: phylogeny, historical biogeography and systematics of the medically important viper genus Echis (Squamata: Serpentes: Viperidae). Mol Phylogenet Evol 53: 792-807.
17. WHO (2010) Guidelines for the Production, Control and Regulation of Snake Antivenom Immnoglobulins. Geneva: World Health Organisation. Available: http://www.who.int/bloodproducts/snake_antivenoms/snakeantivenomguide/en/. Accessed 2010 August 3.
18. Cook DAN, Owen T, Wagstaff SW, Kinne J, Wernery U, Harrison RA (2010) Analysis of camelid antibodies for antivenom development: Neutralisation of venom-induced pathology. Toxicon 56: 373-380.
19. Finney DJ (1971) Probit analysis. London: Cambridge University Press: Third Edition.
20. Segura A, Villalta M, Herrera M, León G, Harrison R (2010) Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa. Toxicon 55: 369-374.
21. Cook DAN, Owen T, Wagstaff SC, Kinne J, Wernery U, Harrison RA (2010) Analysis of camelid IgG for antivenom developments: Serological responses of venom-immunised camels to prepare either monospecific or polyspecific antivenoms for West Africa. Toxicon 56: 363-372.
22. Pugh RN, Theakston RD, Reid HA (1980) Malumfashi endemic diseases research project, XIII. Epidemiology of human encounters with the spitting cobra, Naja nigricollis, in the Malumfashi area of northern Nigeria. Ann Trop Med Parasitol 74(5): 523-530.
23. Nasidi A (2007) Snakebite a serious public health problem for Nigeria and Africa. Available: http://www.who.int/bloodproducts/animal_sera/A.Nasidi.pdf.
24. Warrell DA, Davidson NM, Greenwood BM, Ormerod LD, Pope HM, et al. (1977) Poisoning by bites of the saw-scaled or carpet viper (Echis carinatus) in Nigeria. Q J Med 46: 33-62.
25. Sano-Martins IS, Fan HW, Castro SCB, Tomy SC, Franca FOS, et al. (1994) Reliability of the simple 20 minute whole blood clotting test (WBST20) as an indicator of low plasma fibrinogen concentration in patients envenomed by Bothrops snakes. Toxicon 32(9): 1045-1050.
26. Kaboré J, Revault P (1996) Treatment of envenomation after Echis ocellatus bites in Burkina Faso. Toxicon 34(2): 164.
27. Drame B, Diani N, Togo MM, Maiga M, Diallo D, et al. (2005) Envenomation accidents caused by snakebites in the surgical emergency unit of Gabriel-Toure Hospital, Bamako, Mali (1998-1999). Bulletin De La Societe De Pathologie Exotique 98: 287-289.
28. Chippaux JP (2002) Epidemiology of snakebites in Cote d'Ivoire. Bulletin De La Societe De Pathologie Exotique 95: 167-171.
29. Swiecick AW (1965) Snakes and snake bite in Western Region Ghana. Journal of Tropical Medicine and Hygiene 68: 300.
30. Massougbodji A, Chobli M, Assouto P, Lokossou T, Sanoussi H, et al. (2002) Geoclimatology and severity of snakebite envenomations in Benin. Bulletin De La Societe De Pathologie Exotique 95: 175-177.
31. Chippaux JP, Kambewasso A (2002) Snake bites and availability of antivenom in the urban Community of Niamey. Bulletin De La Societe De Pathologie Exotique 95: 181-183.
32. Einterz EM, Bates ME (2003) Snakebite in northern Cameroon: 134 victims of bites by the saw-scaled or carpet viper, Echis ocellatus. Trans R Soc Trop Med Hyg 97: 693-696.
33. Kochar DK, Tanwar PD, Norris RL, Sabir M, Nayak KC, et al. (2007) Rediscovery of severe saw-scaled viper (Echis sochureki) envenoming in the Thar Desert region of Rajasthan, India. Wilderness Enviro Med 18: 75-85.
34. Visser LE, Kyei-Faried S, Belcher DW, Geelhoed DW, Schagen van Leeuwen J, et al. (2008) Failure of a new antivenom to treat Echis ocellatus snake bite in rural Ghana: the importance of quality surveillance. Trans R Soc Trop Med Hyg 102: 445-450.
35. WHO (2010) Venomous snake distribution database. Available: http://apps.who.int/bloodproducts/snakeantivenoms/database/. Accessed 2010 August 3.