Enhanced lipolysis in normal mice expressing liver-derived human lipoprotein lipase after adenoviral gene transfer

Clinical and Investigative Medicine

Volumn 21, Issue 4-5, 1998, Pages 172-185

  Liu, Guoqing ^a   Ashbourne Excoffon, Katherine J D ^a   Wilson, Janet E ^a   McManus, Bruce M ^a   Miao, Li ^a   Benoit, Patrick ^b   Duverger, Nicolas ^b   Branellec, Didier ^b   Denefle, Patrice ^b   Hayden, Michael R ^a   Lewis, M E Suzanne ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SANOFI   (France)

^c Brit Columbia's Children's W   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHYLOMICRON; LIPOPROTEIN; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FAT INTAKE; GENE EXPRESSION; GENE TRANSFER; GENOTYPE; IN SITU HYBRIDIZATION; LIPOLYSIS; LIPOPROTEIN METABOLISM; LIQUID CHROMATOGRAPHY; LIVER; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TIME; VIRUS PARTICLE;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; CHYLOMICRONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; HUMANS; IN SITU HYBRIDIZATION; LIPOLYSIS; LIPOPROTEIN LIPASE; LIPOPROTEINS; LIVER; MALE; MICE; MICE, INBRED STRAINS; TRIGLYCERIDES;

EID: 7844227671     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Havel RJ. Postprandial hyperlipidemia and remnant lipoproteins. Curr Opin Lipidol 1994;5:102-9.
2. Hodis HN, Mack WJ. Triglyceride-rich lipoproteins and the progression of coronary artery disease. Curr Opin Lipidol 1995;6:209-14.
3. Zilversmit DB. Atherogenic nature of triglycerides, post-prandial lipemia and triglyceride-rich remnant lipoproteins. Clin Chem 1995;41:153-8.
4. Enerback S, Gimble JM. Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. Biochim Biophys Acta 1993;1169:107-25.
5. Murthy V, Julien P, Gagne C. Molecular pathobiology of the human lipoprotein lipase gene. Pharmacol Ther 1996;70:101-35.
6. Shepherd J. Fibrates and statins in the treatment of hyperlipidemia: an appraisal of their efficacy and safety. Eur Heart J 1995;16:5-13.
7. Liu MS, Jirik FR, LeBoeuf RC, Henderson H, Castellani LW, Lusis AJ, et al. Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase. J Biol Chem 1994;269:11417-24.
8. Zsigmond E, Scheffler E, Forte TM, Potenz R, Wu W, Chan L. Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. J Biol Chem 1994;269:18757-66.
9. Shimada M, Shimano H, Gotoda T, Yamamoto K, Kawamura M, Inaba T, et al. Overexpression of human lipoprotein lipase in transgenic mice. J Biol Chem 1993;268:17924-9.
10. Tsutsumi K, Inoue Y, Shima A, Iwasaki K, Kawamura M, Murase T. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high-density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. J Clin Invest 1993;92:411-7.
11. Tsutsumi K, Inoue Y, Shima A, Murase T. Correction of hypertriglyceridemia with low high-density lipoprotein cholesterol by the novel compound NO-1886, a lipoprotein lipase-promoting agent, in STZ-induced diabetic rats. Diabetes 1995;44:414-7.
12. Shimada M, Ishibashi S, Inaba T, Yagyu H, Harada K, Osuga J, et al. Suppression of diet-induced atherosclerosis in low-density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci USA 1996;93:7242-6.
13. Li Q, Kay MA, Finegold M, Stratford-Perricaudet LD, Woo SL. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther 1993;4:403-9.
14. Barr D, Tubb J, Ferguson D, Scaria A, Lieber A, Wilson C, et al. Strain related variations in adenovirally mediated transgene expression from mouse epatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther 1995;2:151-5.
15. Huard J, Lochmüler H, Acsadi G, Jani A, Massie B, Karpati G, et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther 1995;2:107-15.
16. Chan L. Use of somatic gene transfer to study lipoprotein metabolism in experimental animals in vivo. Curr Opin Lipidol 1995;6:335-40.
17. Gerard RD, Chan L. Adenovirus-mediated gene transfer: strategies and applications in lipoprotein research. Curr Opin Lipidol 1996;7:105-11.
18. Auwerx J, Schoonjans K, Staels B. Regulation of liver lipoprotein lipase gene expression. In: Woodward FP, Davignon J, Sniderman A, editors. Atherosclerosis X. Amsterdam: Elsevier Science; 1995. p. 241-5.
19. Bengtsson-Olivecrona G, Olivecrona T, Hultin M, Liu G, Vilaro S. Uptake of lipoprotein lipase in the liver: mechanism and physiological relevance. In: Winkler E, editor. Hepatic endocytosis of lipids and proteins. W. Zuckswerdt Verlag; 1992. p. 292-8.
20. Ashbourne Excoffon KJD, Liu G, Miao L, Wilson JE, McManus BM, Semenkovich CF, et al. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arterioscler Thromb Vasc Biol 1997;17:2532-9.
21. Kobayashi J, Applebaum-Bowden D, Dugi KA, Brown DR, Kashyap VS, Parrott C, et al. Analysis of protein structure-function in vivo; adenovirus-mediated transfer of lipase lid mutants in hepatic lipase-deficient mice. J Biol Chem 1996;271:26296-301.
22. Zsigmond E, Kobayashi K, Tzung K-W, Li L, Fuke Y, Chan L. Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice. Hum Gene Ther 1997;8:1921-33.
23. Liu G, Ashbourne Excoffon KJD, Benoit P, Ginzinger D, Miao L, Ehrenborg E, et al. Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells. Hum Gene Ther 1997;8:205-14.
24. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992;90:626-30.
25. Peterson J, Fujimoto WY, Brunzell JD. Human lipoprotein lipase: relationship of activity, heparin affinity and conformation as studied with monoclonal antibodies. J Lipid Res 1992;33:1165-70.
26. Nilsson-Ehle P, Schotz MC. A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J Lipid Res 1976;17:536-41.
27. Brunzell JD. Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrome. In: Scriver CR, Beaudet AL, Sly WL, Valle D, editors. Metabolic basis of inherited disease. 7th ed. New York: McGraw-Hill Book Co.; 1995. p. 1913-32.
28. Homanics GE, de Silva HV, Osada J, Zhang SH, Wong H, Borensztajn J, et al. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J Biol Chem 1995;270(7):2974-80.
29. Beisiegel U, Weber W, Bengtsson-Olivecrona G. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci USA 1991;88:8342-6.
30. Skottova N, Savonen R, Lookene A, Hultin M, Olivecrona G. Lipoprotein lipase enhances removal of chylomicrons and chylomicron remnants by the perfused rat liver. J Lipid Res 1995;36:1334-44.
31. Kass-Eisler A, Falck-Pedersen E, Elfenbein DH, Alvira M, Buttrick PM, Leinwand LA. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther 1994;1:395-402.
32. Kirchgessner TG, Svenson KL, Lusis AL, Schotz MC. The sequence of cDNA encoding lipoprotein lipase; a member of a lipase gene family. J Biol Chem 1987;262:8463-6.