Impact of microbial tolerance in persistent secondary Klebsiella pneumoniae peritonitis

Cytokine

Volumn 53, Issue 1, 2011, Pages 84-93

  Lenz, Andreas M ^a   Qadan, Motaz ^b   Gardner, Sarah A ^a,b   Cheadle, William G ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Cytokine; Pathogen associated molecular patterns; Peritonitis; Tolerance; Toll like receptors

Indexed keywords

BACTERIAL PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; LIPOPROTEIN; NITRIC OXIDE; PATTERN RECOGNITION RECEPTOR; PHOSPHATE BUFFERED SALINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL METABOLISM; BACTERIAL PERITONITIS; BLOOD ANALYSIS; C57BL 6 MOUSE; CELL COUNT; CELL STIMULATION; COLONY FORMING UNIT C; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE INFECTION; LIVER PARENCHYMA; MACROPHAGE ACTIVATION; MALE; MICROBIAL ACTIVITY; MICROBIAL ATTENUATION; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERSISTENT INFECTION; PRIORITY JOURNAL; SECONDARY INFECTION; SURVIVAL RATE; WEIGHT REDUCTION;

ANIMALS; BACTERIAL LOAD; BUFFERS; CELL COUNT; CYTOKINES; IMMUNE TOLERANCE; KLEBSIELLA PNEUMONIAE; LIGANDS; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; PERITONEAL CAVITY; PERITONITIS; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTORS; WEIGHT LOSS;

ANIMALIA; BACTERIA (MICROORGANISMS); KLEBSIELLA; KLEBSIELLA PNEUMONIAE; MURINAE; MUS;

EID: 78349306890     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2010.08.012     Document Type: Article

References (49)

1. Marshall J.C. Intra-abdominal infections. Microbes Infect 2004, 6:1015-1025.
2. Calandra T., Cohen J. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 2005, 33:1538-1548.
3. Evans H.L., Raymond D.P., Pelletier S.J., Crabtree T.D., Pruett T.L., Sawyer R.G. Diagnosis of intra-abdominal infection in the critically ill patient. Curr Opin Crit Care 2001, 7:117-121.
4. Lamme B., Boermeester M.A., Belt E.J., van Till J.W., Gouma D.J., Obertop H. Mortality and morbidity of planned relaparotomy versus relaparotomy on demand for secondary peritonitis. Br J Surg 2004, 91:1046-1054.
5. Koperna T., Schulz F. Prognosis and treatment of peritonitis. Do we need new scoring systems?. Arch Surg 1996, 131:180-186.
6. Nathens A.B., Rotstein O.D., Marshall J.C. Tertiary peritonitis: clinical features of a complex nosocomial infection. World J Surg 1998, 22:158-163.
7. Majetschak M., Krehmeier U., Bardenheuer M., Denz C., Quintel M., Voggenreiter G., et al. Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness. Blood 2003, 101:1882-1890.
8. Docke W.D., Randow F., Syrbe U., Krausch D., Asadullah K., Reinke P., et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997, 3:678-681.
9. Flach R., Majetschak M., Heukamp T., Jennissen V., Flohe S., Borgermann J., et al. Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis. Cytokine 1999, 11:173-178.
10. Munoz C., Carlet J., Fitting C., Misset B., Bleriot J.P., Cavaillon J.M. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991, 88:1747-1754.
11. Schinkel C., Sendtner R., Zimmer S., Faist E. Functional analysis of monocyte subsets in surgical sepsis. J Trauma 1998, 44:743-748.
12. Hall M.W., Gavrilin M.A., Knatz N.L., Duncan M.D., Fernandez S.A., Wewers M.D. Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res 2007, 62:597-603.
13. Ploder M., Pelinka L., Schmuckenschlager C., Wessner B., Ankersmit H.J., Fuerst W., et al. Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients. Shock 2006, 25:129-134.
14. Volk H.D., Reinke P., Krausch D., Zuckermann H., Asadullah K., Muller J.M., et al. Monocyte deactivation-rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996, 22(Suppl 4):S474-S481.
15. Schroder M., Meisel C., Buhl K., Profanter N., Sievert N., Volk H.D., et al. Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN-gamma production: consequences for reversal of lipopolysaccharide desensitization. J Immunol 2003, 170:5260-5267.
16. Grutz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol 2005, 77:3-15.
17. Greisman S.E., Hornick R.B. The nature of endotoxin tolerance. Trans Am Clin Climatol Assoc 1975, 86:43-50.
18. Beeson P.B. Tolerance to bacterial pyrogens. I. Factors influencing its development. J Exp Med 1947, 86(29).
19. Cavaillon J.M., Adib-Conquy M. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit Care 2006, 10:233.
20. Greisman S.E., Young E.J., Woodward W.E. Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin. J Exp Med 1966, 124:983-1000.
21. Mengozzi M., Ghezzi P. Cytokine down-regulation in endotoxin tolerance. Eur Cytokine Netw 1993, 4:89-98.
22. Gordon S. Pattern recognition receptors: doubling up for the innate immune response. Cell 2002, 111:927-930.
23. Chen K., Huang J., Gong W., Iribarren P., Dunlop N.M., Wang J.M. Toll-like receptors in inflammation, infection and cancer. Int Immunopharmacol 2007, 7:1271-1285.
24. Medvedev A.E., Sabroe I., Hasday J.D., Vogel S.N. Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res 2006, 12:133-150.
25. Dobrovolskaia M.A., Medvedev A.E., Thomas K.E., Cuesta N., Toshchakov V., Ren T., et al. Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR " homotolerance" versus " heterotolerance" on NF-kappa B signaling pathway components. J Immunol 2003, 170:508-519.
26. Woods D.R., Peyton J.C., Franklin G.A., Turina M., Cheadle W.G. Decreased neutrophil response in a model of chronic intraperitoneal Klebsiella infection. Surg Infect (Larchmt) 2007, 8:367-376.
27. Lenz A.M., Franklin G.A., Fairweather M., McClintock M.L., Jala V.R., Peyton J.C., et al. Endogenous IL-10 leads to impaired bacterial clearance and reduced survival in a murine model of chronic peritonitis. Cytokine 2007, 40:207-215.
28. Lenz A.M., Turina M., Alard P., Gardner S.A., Cheadle W.G. Microbial tolerance in secondary peritonitis is dose dependent. Cell Immunol 2009, 258:98-106.
29. Schurr J.R., Young E., Byrne P., Steele C., Shellito J.E., Kolls J.K. Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 2005, 73:532-545.
30. Wu J.H., Hong L.C., Tsai Y.Y., Chen H.W., Chen W.X., Wu T.S. Mitogen-activated protein kinase (MAPK) signalling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae. Cell Microbiol 2006, 8:1467-1474.
31. Cailhier J.F., Partolina M., Vuthoori S., Wu S., Ko K., Watson S., et al. Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J Immunol 2005, 174:2336-2342.
32. Freudenberg M.A., Galanos C. Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect Immun 1988, 56:1352-1357.
33. Madonna G.S., Vogel S.N. Induction of early-phase endotoxin tolerance in athymic (nude) mice, B-cell-deficient (xid) mice, and splenectomized mice. Infect Immun 1986, 53:707-710.
34. Fang F.C. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2004, 2:820-832.
35. Tsai W.C., Strieter R.M., Zisman D.A., Wilkowski J.M., Bucknell K.A., Chen G.H., et al. Nitric oxide is required for effective innate immunity against Klebsiella pneumoniae. Infect Immun 1997, 65:1870-1875.
36. Dias M.B., Almeida M.C., Carnio E.C., Branco L.G. Role of nitric oxide in tolerance to lipopolysaccharide in mice. J Appl Physiol 2005, 98:1322-1327.
37. Fitting C., Dhawan S., Cavaillon J.M. Compartmentalization of tolerance to endotoxin. J Infect Dis 2004, 189:1295-1303.
38. Wysocka M., Robertson S., Riemann H., Caamano J., Hunter C., Mackiewicz A., et al. IL-12 suppression during experimental endotoxin tolerance. dendritic cell loss and macrophage hyporesponsiveness. J Immunol 2001, 166:7504-7513.
39. Murphey E.D., Fang G., Sherwood E.R. Endotoxin pretreatment improves bacterial clearance and decreases mortality in mice challenged with Staphylococcus aureus. Shock 2008, 29:512-518.
40. O'Brien G.C., Wang J.H., Redmond H.P. Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance. J Immunol 2005, 174:1020-1026.
41. Wheeler D.S., Lahni P.M., Denenberg A.G., Poynter S.E., Wong H.R., Cook J.A., et al. Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis. Shock 2008, 30:267-273.
42. Broug-Holub E., Toews G.B., van Iwaarden J.F., Strieter R.M., Kunkel S.L., Paine R., et al. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun 1997, 65:1139-1146.
43. Hirche T.O., Gaut J.P., Heinecke J.W., Belaaouaj A. Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. J Immunol 2005, 174:1557-1565.
44. Fahmi H., Charon D., Mondange M., Chaby R. Endotoxin-induced desensitization of mouse macrophages is mediated in part by nitric oxide production. Infect Immun 1995, 63:1863-1869.
45. Murphey E.D., Sherwood E.R. Bacterial clearance and mortality are not improved by a combination of IL-10 neutralization and IFN-gamma administration in a murine model of post-CLP immunosuppression. Shock 2006, 26:417-424.
46. Feterowski C., Novotny A., Kaiser-Moore S., Muhlradt P.F., Rossmann-Bloeck T., Rump M., et al. Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation. Int Immunol 2005, 17:1035-1046.
47. van Heeckeren A.M., Schluchter M.D., Xue W., Davis P.B. Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice. Am J Respir Crit Care Med 2006, 173:288-296.
48. Buyne O.R., Bleichrodt R.P., Verweij P.E., Groenewoud H.M., van Goor H., Hendriks T. A peritonitis model with low mortality and persisting intra-abdominal abscesses. Int J Exp Pathol 2006, 87:361-368.
49. Foster S.L., Hargreaves D.C., Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007, 447:972-978.