Cortisol response to individualised graded insulin infusions: A reproducible biomarker for CNS compounds inhibiting HPA activation

British Journal of Clinical Pharmacology

Volumn 70, Issue 6, 2010, Pages 886-894

  Chen, Christopher L H ^a   Willis, Brian A ^b   Mooney, Louise ^c   Ong, Guan Koon ^d   Lim, Chay Ngee ^d   Lowe, Stephen L ^d   Tauscher Wisniewski, Sitra ^b   Cutler Jr, Gordon B ^b   Wiss, Stephen D ^d  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b ELI LILLY AND COMPANY   (United States)

^c MerLion Pharmaceuticals GmbH   (Germany)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cortisol; Hypoglycaemia; Hypothalamic pituitary adrenocortical axis; Insulin infusion; Insulin tolerance test

Indexed keywords

GLUCOSE; HYDROCORTISONE; INSULIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DIZZINESS; DROWSINESS; DRUG EFFECT; DRUG INFUSION; DRUG RESPONSE; DRUG SAFETY; FATIGUE; GLUCOSE BLOOD LEVEL; HUMAN; HUNGER; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN HYPOGLYCEMIA; MALE; PRIORITY JOURNAL; SIDE EFFECT; SWEATING;

ADULT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; MALE; MIDDLE AGED; PILOT PROJECTS; PITUITARY-ADRENAL SYSTEM; STRESS, PHYSIOLOGICAL; YOUNG ADULT;

EID: 78349300263     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03781.x     Document Type: Article

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