Anti-inflammatory and enzyme inhibitory activities of a crude extract and a pterocarpan isolated from the aerial parts of Vitex agnus-castus

Biotechnology Journal

Volumn 5, Issue 11, 2010, Pages 1207-1215

  Ahmad, Bashir ^a   Azam, Sadiq ^a   Bashir, Shumaila ^a   Khan, Ibrar ^a   Adhikari, Achyut ^b   Choudhary, Muhammad Iqbal ^b  

^a UNIVERSITY OF PESHAWAR   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Anti inflammatory; Antibacterial; Enzyme inhibition; Hemagglutination; Vitex agnus castus

Indexed keywords

AERIAL PARTS; ANTI-BACTERIAL ACTIVITY; ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY ACTIVITY; ANTIBACTERIAL; AQUEOUS FRACTIONS; CRUDE EXTRACT; ETHYL ACETATES; HEMAGGLUTINATION; HUMAN ERYTHROCYTES; IN-VITRO; INHIBITORY ACTIVITY; KLEBSIELLA PNEUMONIA; LEMNA MINOR L; METHANOLIC EXTRACTS; N-HEXANE; PHYTOTOXIC ACTIVITY; SALMONELLA TYPHI; SPECTROSCOPIC TECHNIQUE; VITEX AGNUS-CASTUS;

BACTERIOLOGY; ENZYMES; ESTERS; HEXANE; PULMONARY DISEASES;

ENZYME INHIBITION;

ACETIC ACID ETHYL ESTER; CHYMOTRYPSIN; COAL TAR; PTEROCARPAN DERIVATIVE; UREASE; VITEX AGNUS CASTUS EXTRACT;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG ISOLATION; ENTEROBACTER AEROGENES; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; ESCHERICHIA COLI; FRACTIONATION; HEMAGGLUTINATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NEUTROPHIL; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHYTOTOXICITY; PLANT; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS EPIDERMIDIS; VITEX AGNUS CASTUS;

ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BACILLUS; CHYMOTRYPSIN; COMPLEX MIXTURES; ENZYME ACTIVATION; ENZYME INHIBITORS; HEMAGGLUTINATION; HUMANS; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PTEROCARPANS; SALMONELLA TYPHI; UREASE; VITEX;

KLEBSIELLA PNEUMONIAE; LEMNA MINOR; SALMONELLA TYPHI; VITEX AGNUS-CASTUS;

EID: 78349291196     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201000020     Document Type: Article

References (51)

1. Liu, M. T., Lin, S., Wang, Y. H., He, W. Y. et al., Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis. Org. Lett. 2007, 9, 129-132.
2. Morita, H., Eda, M., Iizuka, T., Hirasawa, Y. et al., Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis. Bioorg. Med. Chem. Lett. 2006, 16, 4458-4461.
3. Pepeljnjak, S., Kalogjera, Z., Zovko, M., Antimicrobial activity of flavonoids from Pelargonium radula (Cav). Acta Pharm. 2005, 55, 431-435.
4. Nasir, E., Ali, S. I., Flora of West Pakistan; Verbenaceae, No. 77 complied by S. M. H. Jafri, Abdul Ghafoor, 1974, p. 01.
5. Sastri, B. N., The Wealth of India, A Dictionary of Raw Material and Industrial Products. Publication and information directorate CSIR New Delhi, 1950 5, 285-293.
6. Hartung, T., Growing 101 Herbs That Heal. Storey Books, North Adams, MA 2000.
7. Chevallier, A., Encyclopedia of Herbal Medicine. Dorling Kindersley, New York 2000.
8. Okuyama, E., Fujmori, S., Yamazaki, M., Deyama, T., Pharmacologically active components of Viticis Fructus (Vitex rotundifolia) II. The components having analgesic effects. Chem. Pharm. Bull. 1998, 46, 655-662.
9. You, K. M. J., Kim, H. P., Inhibition of cyclooxygenase/lipoxygenase from human platlets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch. Pharm. Res. 1999, 22, 18-24.
10. Ko, W. G. K., Lee, T. H., Kim, N. Y., Sohn, D. H., Lee, B. H., Polymethoxy flavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem. Toxcol. 2000, 38, 861-865.
11. Ono, M. I. Y., Nohara, T., A labdan diterpene glycoside from fruits of Vitex rotundifolia. Phytochemistry 1998, 48, 207-209.
12. Tereza, C. D. S., Franco, D. M., Suzana, G. L., Ecdysteroids from two Brazilian Vitex species. Fitoterapia 2001, 48, 215-222.
13. Werawattanametin, K., Podimuang, V., Suksamrarn, A. J., Ecdysteroids from Vitex glabrata. Nat. Prod. 1986, 49, 365-366.
14. Ono, M., Yamasaki, T., Konoshita, M., Ikeda, T. et al., Five new diterpenoids, viteagnusins A-E, from the fruit of Vitex agnus castus. Chem. Pharm. Bull. 2008, 48, 1084-108.
15. Zhang, M., Stout, M., Kubo, I., Ecdysteroids from Vitex glabrata. Phytochemistry 1991, 72, 215-220.
16. Saden-Krehula, M., Kustrak, D., Blazevic, N., β-4-3-Ketosteroids in flowers and leaves of Vitex agnus castus. Planta Med. 1990, 56, 547-549.
17. Suksamrarn, A., Promrangsan, N., Jintasirikulb, A., Highly oxygenated ecdysteroids from Vitex canescens root bark. Phytochemistry 2000, 53, 921-923.
18. Ibrahim, N. A., Shalaby, A. S., Farag, R. S., Elbaroty, G. S. et al., Phytochemical investigation and hormonal activity of Vitex agnus castus fruits growing in Egypt. J. Arab Soc. Med. Res. 2006, 1, 63-74.
19. Hoberg, E., Orjala, J., Meie, B., Sticher, O., An analytical high performance liquid chromatographic method for the determination of agnuside and ρ-hydroxybenzoic acid contents in Agni casti Fructus. Phytochemistry 1999, 52, 1555-1558.
20. Zhang, L. S., Qui, H., Niu, S., Santarsiero, X. et al., Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus castus. Tetrahydron Lett. 2002, 43, 5131-5134.
21. Suksamrarn, A., Sommechai, C., Charulpong, P., Chitkul, B., Ecdysteroids from Vitex canescens. Phytochemistry 1995, 38, 473-476.
22. Mehlhorn, H., Schmahl, G., Schmidt, J., Extract of the seeds of the plant Vitex agnus castus proven to be highly efficacious as a repellent against ticks, fleas, mosquitoes and biting flies. Parasitol. Res. 2005, 95, 363-365.
23. Schertz, K. F., Boyd, K. F., Jurgelsky, W., Cabanillas, E., Seed extracts with agglutinating activity for human blood. J. Econ. Bot. 1960, 14, 232-240.
24. Kobaisy, M., Tellez, M. R., Dayan, F. E., Duke, S. O., Phytotoxicity and volatile constituents from leaves of Callicarpa japonica Thunb. Phytochemistry 2002, 61, 37-40.
25. Shaukat, M., Huma, S., Umbreen, F., Arfa, K., Antifungal activities of Vitex negundo Linn. Pak. J. Bot. 2009, 41, 1941-1943.
26. Amann, W., Acne vulgaris, Agrus castus (agnolyt). Z. Allg. Med. 1975, 35, 1645-1647.
27. Bhargava, S. K., Antiandrogenic effect of flavanoids rich fraction of Vitex negundo seeds: A histological and biochemical study in dog. J. Ethnopharmacol. 1989, 27, 327-339.
28. Cannell, R. J. P., Kellam, S. J., Owsianka, A. M., Walker, J. M., Results of a large scale screen of microalgae for the production of protease inhibitors. Planta Med. 1988, 54, 10-14.
29. Akhtar, T., Hameed, S., Khan, K. M., Chaudhary, M. I., Syntheses, urease inhibition and antimicrobial studies of some chiral 3-substituted-4-amino-5-thioxo-1H, 4H-1, 2, 4-triazoles. Med. Chem. 2008, 4, 539-54.
30. Siddiqui, R. A., English, D., Cui, Y., Phorbal ester induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophils cytoplasts. J. Leukoc. Biol. 1995, 58, 189-195.
31. Tan, A. S., Berridge, V. M., Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: A simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents, J. Immunol. Methods 2000, 238, 50-68.
32. Naqvi, S. B., Shaikh, D., Usmanghani, K., Shameel, M., Shaikh, R., Screening of marine algae of Karachi for haemagglutinin activity. Pak. J. Pharm. Sci. 1992, 5, 129-13.
33. Ahmad, B., Ali, N., Bashir, S., Choudhary, M. I. et al., Parasiticidal, antifungal and antibacterial activities of Onosma griffithii Vatke. Afr. J. Biotechnol. 2009, 8, 5084-5087.
34. Banso, A., Phytochemical and antibacterial investigation of bark extracts of Acacia nilotica. J. Med. Plants Res. 2009, 3, 082-085.
35. Ahmad, B., Ali, N., Bashir, S., Choudhary, M. I., Biological activities of aerial parts of Tylophora hirsuta Wall. Afr. J. Biotechnol. 2009, 8, 4627-4631.
36. Mizuno, M., Tanaka, T., katsuragawa, M., Saito, H., Iinuma, M., A new pterocarpan from the heartwood of cladrastis platycarpa. J. Nat. Prod. 1990, 33, 2, 498-499.
37. Trong, T. D., Phi, H. N., Phuong, T. T., Keon, W. K. et al., Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina Hutch. Phytochemistry 2009, 70, 2053-2057.
38. Chaudhuri, S. K., Huang, L., Fekadu, F., Brown, D. M. et al., Isolation and structure identification of an active DNA strand-scission agent, (+)-3, 4-dihydroxy-8, 9-methylenedioxypterocarpan. J. Nat. Prod. 1995, 58, 1966-1969.
39. Lorand, K., Tibor, K., Sandor, A., Attila, B., Chiroptical properties and synthesis of enantiopure cis and trans pterocarpan skeleton. Chirality 2003, 15, 558-563.
40. Jiménez-González, L., Álvarez-Corral, M., Muñoz-Dorado, M., Rodríguez-García, I., A concise and diastereoselective total synthesis of cis and trans-pterocarpans. Chem. Commun. 2005, 2689-2691.
41. Amtul, Z., Rehman, A. U., Siddiqui, R. A., Choudhary, M. I., Chemistry and mechanism of urease inhibition. Curr. Medi. Chem. 2002, 9, 1323-1348.
42. Radau, G., Cyanopeptides: A new and nearly inexhaustible natural resource for the design and structure activity relationship studies of the new inhibitors of trypsin-like serine proteases. Curr. Enzyme Inhib. 2005, 1, 295-307.
43. Lodhi, A., Choudhary, M. I., Malik, A., Ahmad, S., Alpha-chymotrypsin inhibition studies on the lignans from Vitex negundo Linn. J. Enzyme Inhib. Med. Chem. 2008, 30, 400-405.
44. 3 in interleukin 1-beta generation. Clin. Exp. Immunol. 2007, 147, 227-235.
45. Pusztai, A., Biological effects of dietary lectins, in: Huisman, J., van der Poel, A. F. B. (Eds.), Recent Advances of Research in Anti-nutritional Factors in Legume Seeds, Pudoc, Wageningen 1989, pp. 17-29.
46. Aswar, P. B., Khadabadi, S. S., Kuchekar, B. S., Rajurkar, R. M. et al., In vitro evaluation of anti-bacterial and anti-fungal activity of Vitex nigundo (Verbenaceae). Ethnobot. Leaflets 2009, 13, 962-967.
47. Freeman, C. D., Antimicrobial resistance; implications for the clinician. J. Crit. Care Nurs. 1997, 20, 21-35.
48. Danso, A. A., Sake Vlas, T. D. C., Interpretation of low praziquantel cure rates of Schistosoma mansoni. Trends Parasitol. 2002, 18, 95-143.
49. Kilani, A. M., Antibacterial assessment of whole stem bark of Vitex doniana against some enterobactriaceae. Afr. J. Biotechnol. 2006, 5, 958-959.
50. Nyiligira, E., Viljoen, A. M., Heerden, F. R. V., Zyl, R. L. V. et al., Phytochemistry and in vitro pharmacological activities of South African Vitex (Verbenaceae) species. J. Ethnopharmacol. 2008, 119, 680-685.
51. Rehman, A. U., Studies in Natural Product Chemistry, vol. 9. Elsevier Science, Amsterdam 1991, pp. 383-409.