Understanding cost-effectiveness

Clinical Microbiology and Infection

Volumn 16, Issue 12, 2010, Pages 1707-1712

  Zilberberg, M D ^a,b   Shorr, A F ^c,d  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EviMed Research Group LLC   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

Cost effectiveness; Health economics; Healthcare associated infections; Outcomes; Review

Indexed keywords

FLUCONAZOLE; LINEZOLID; MICAFUNGIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; COST EFFECTIVENESS ANALYSIS; HEALTH CARE COST; HEALTH CARE DELIVERY; HEALTH CARE SYSTEM; HOSPITAL COST; HUMAN; LIFE EXPECTANCY; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; REVIEW;

EID: 78349288817     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2010.03331.x     Document Type: Review

References (21)

1. Institute of Medicine. To err is human: building a safer health system. Washington: National Academies Press, 1999.
2. McGlynn EA, Asch SM, Adams J et al. The quality of health care delivered to adults in the United States. N Engl J Med 2003; 348: 2635-2645.
3. Klevens RM, Edwards JR, Richards CL Jr et al. Estimating health care-associated infections and deaths in US hospitals, 2002. Public Health Rep 2007; 122: 160-166.
4. Scott RD. The direct medical costs of healthcare-associated infections in US hospitals and the benefits of prevention. Centers for Disease Control and Prevention report, March 2009. Available at: (last accessed 21 June 2010).
5. Schwartz K, Vilquin JT. Building the translational highway: toward new partnerships between academia and the private sector. Nat Med 2003; 9: 493-495.
6. Weinstein MC, Siegel JE, Gold MR et al. Recommendations of the panel on cost-effectiveness in health and medicine. JAMA 1996; 276: 1253-1258.
7. Angus DC, Linde-Zwirble WT, Clermont G et al. Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med 2003; 31: 1-11.
8. Khazeni N, Hutton DW, Garber AM et al. Effectiveness and cost-effectiveness of vaccination against pandemic influenza (H1N1) 2009. Ann Intern Med 2009; 151: 829-839.
9. Dan YY, Tambyah PA, Sim J et al. Cost-effectiveness analysis of hospital infection control response to an epidemic respiratory virus threat. Emerg Infect Dis 2009; 15: 1909-1916.
10. Weinstein MC, Skinner JA. Comparative effectiveness and healthcare spending-implications for reform. N Engl J med 2010; 362: 1845-1846.
11. Shorr AF, Susla GM, Kollef MH. Linezolid for the treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med 2004; 32: 137-143.
12. Shorr AF, Zilberberg MD, Kollef MH. Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 2009; 30: 759-763.
13. Zilberberg MD, Kothari S, Shorr AF. Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation. Crit Care 2009; 13: R94.
14. Price KF. Pricing Medicare's diagnosis-related groups: charges versus estimated costs. Health Care Financing Review, Fall 1989. Available at: (last accessed 18 September 2009).
15. Kahn JM, Rubenfeld GD, Rohrbach J, Fuchs BD. Cost savings attributable to reductions in intensive care unit length of stay for mechanically ventilated patients. Med Care 2008; 46: 1226-1233.
16. Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 2005; 33: 1266-1271.
17. Huang DT, Clermont G, Dremsizov TT, Angus DC, ProCESS Investigators. Implementation of early goal-directed therapy for severe sepsis and septic shock: a decision analysis. Crit Care Med 2007; 35: 2090-2100.
18. Pronovost PJ, Needham DM, Waters H et al. Intensive care unit physician staffing: financial modeling of the Leapfrog standard. Crit Care Med 2004; 32: 1247-1253.
19. Kahn JM, Kramer AA, Rubenfeld GD. Transferring critically ill patients out of hospital improves the standardized mortality ratio: a simulation study. Chest 2007; 131: 68-75.
20. Institute for Healthcare Improvement. Available at: (last accessed 21 June 2010).
21. Zilberberg MD, Shorr AF, Kollef MH. Implementing quality improvements in the intensive care unit: ventilator bundle as an example. Crit Care Med 2009; 37: 305-309.