Effectiveness and cost-effectiveness of vaccination against pandemic influenza (H1N1) 2009

Annals of Internal Medicine

Volumn 151, Issue 12, 2009, Pages 829-839

  Khazeni, Nayer ^a   Hutton, David W ^b   Garber, Alan M ^b   Hupert, Nathaniel ^c   Owens, Douglas K ^b  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ARTHRALGIA; ARTICLE; CLINICAL EFFECTIVENESS; COMPARTMENT MODEL; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; COST UTILITY ANALYSIS; DISEASE COURSE; EARLY INTERVENTION; ECCHYMOSIS; EPIDEMIC; FACE MASK; FATIGUE; FEVER; GUILLAIN BARRE SYNDROME; HAND WASHING; HEADACHE; HUMAN; INCUBATION TIME; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; INJECTION SITE ERYTHEMA; INJECTION SITE INDURATION; INJECTION SITE PAIN; INJECTION SITE SWELLING; MORTALITY; MYALGIA; PANDEMIC; PATIENT CARE; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; SEASONAL VARIATION; SENSITIVITY ANALYSIS; SHIVERING; SIDE EFFECT; SWEATING; UNITED STATES; VIRUS INFECTIVITY; VIRUS TRANSMISSION;

COST-BENEFIT ANALYSIS; DECISION SUPPORT TECHNIQUES; DISEASE OUTBREAKS; DISEASE PROGRESSION; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MARKOV CHAINS; MASS VACCINATION; QUALITY-ADJUSTED LIFE YEARS; SEASONS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; UNITED STATES;

EID: 72949083768     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0000605-200912150-00157     Document Type: Article

References (99)

1. World Health Organization. Pandemic (H1N1) 2009 - update 62. 13 August 2009. Accessed at www.who.int/csr/don/2009-08-19/en/index.html on 18 August 2009.
2. World Health Organization. World now at the start of the 2009 influenza pandemic. 11 June 2009. Accessed at www.who.int/mediacentre/news/statements/ 2009/h1n1-pandemic-phase6-20090611/en/index.html on 28 July 2009.
3. Centers for Disease Control and Prevention (CDC). Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep. 2009;58:521-524 [PMID: 19478718]
4. World Health Organization. Pandemic influenza vaccine manufacturing process and timeline. 6 August 2009. Accessed at www.who.int/csr/disease/ swineflu/notes/h1n1-vaccine-20090806/en/index.html on 6 August 2009.
5. DeNoon DJ. Swine flu vaccine timeline: key decisions, key milestones. 20 July 2009. Accessed at www.webmd.com/cold-and-flu/news/20090720/swine-flu- vaccine-when on 28 July 2009.
6. Anderson RM, May RM. Immunisation and herd immunity. Lancet. 1990;335:641-645 [PMID: 1969023]
7. McKay B. Pregnant women, kids, to get vaccine first. 30 July 2009. Accessed at http://online.wsj.com/article/SB124887563173290207.html on 30 July 2009.
8. Roos R. HHS advisors urge full speed on H1N1 vaccine production. 17 July 2009. Accessed at www.cidrap.umn.edu/cidrap/content/influenza/swineflu/news /jul1709board.html on 1 August 2009.
9. Galli G, Hancock K, Hoschler K, DeVos J, Praus M, Bardelli M, et al. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc Natl Acad Sci U S A. 2009;106:7962-7967 [PMID: 19416838]
10. Weinstein MC, Siegel JE, Gold MR, Kamlet MS, Russell LB. Recommendations of the Panel on Cost-effectiveness in Health and Medicine. JAMA. 1996;276:1253-1258 [PMID: 8849754]
11. Bureau of Vital Statistics. New York City Department of Health and Mental Hygiene. Summary of Vital Statistics 2007: The City of New York. 2007. Accessed at www.nyc.gov/html/doh/downloads/pdf/vs/2007sum.pdf on 17 July 2009.
12. New York City Department of Health and Mental Hygiene. Health Alert 22: Pandemic (H1N1) 2009 Influenza Update. Revised reporting requirements and testing procedures. 12 June 2009. Accessed at www.nyc.gov/html/doh/downloads/ pdf/cd/2009/09md22.pdf on 29 July 2009.
13. Centers for Disease Control and Prevention. 2008-2009 influenza season week 21 ending May 30, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008 -2009/weekly21.htm on 29 July 2009.
14. Centers for Disease Control and Prevention. 2008-2009 influenza season week 19 ending May 16, 2009. Accessed at www.cdc.gov/flu/weekly/pdf/External- F0919.pdf on 29 July 2009.
15. Centers for Disease Control and Prevention. 2008-2009 influenza season week 20 ending May 23, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly20.htm on 29 July 2009.
16. Centers for Disease Control and Prevention. Briefing on public health investigation of human cases of H1N1 flu (swine flu). Accessed at www.cdc.gov/media/transcripts/2009/t090501.htm on 17 June 2009.
17. Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, et al; WHO Rapid pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A (H1N1): early findings. Science. 2009;324:1557-1561 [PMID: 19433588]
18. Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers LA, Skowronski DM, et al. Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza Other Respi Viruses. 2009;3:215-222 [PMID: 19702583]
19. New York City Department of Health and Mental Hygiene. Health Alert #27: Pandemic (H1N1) 2009 influenza update, revised reporting requirements and testing procedures, July 8, 2009. Accessed at www.nyc.gov/html/doh/downloads/ pdf/cd/2009/09md27.pdf on 29 July 2009.
20. New York City Department of Health and Mental Hygiene. Health Alert #19: Pandemic (H1N1) 2009 influenza update, revised reporting requirements and testing procedures, May 21, 2009. Accessed at www.nyc.gov/html/doh/downloads/ pdf/cd/2009/09md19.pdf on 29 July 2009.
21. New York City Department of Health and Mental Hygiene. Health Alert #17: Pandemic (H1N1) 2009 influenza update, revised reporting requirements and testing procedures, 12 May 2009. Accessed at www.nyc.gov/html/doh/downloads/pdf/ cd/2009/09md17.pdf on 29 July 2009.
22. New York City Department of Health and Mental Hygiene. Health Alert #21: Pandemic (H1N1) 2009 influenza update, revised reporting requirements and testing procedures, 2 June 2009. Accessed at www.nyc.gov/html/doh/downloads/pdf/ cd/2009/09md21.pdf on 29 July 2009.
23. NY1 News. New York confirms six more H1N1-related deaths. 1 July 2009. Accessed at www.nypolitics.com/2009/07/01/new-york-city-confirms-six-more-h1n1- related-deaths/ on 29 July 2009.
24. Katz JM, Lim W, Bridges CB, Rowe T, Hu-Primmer J, Lu X, et al. Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts. J Infect Dis. 1999;180:1763-1770 [PMID: 10558929]
25. Vong S, Coghlan B, Mardy S, Holl D, Seng H, Ly S, et al. Low frequency of poultry-to-human H5NI virus transmission, southern Cambodia, 2005. Emerg Infect Dis. 2006;12:1542-1547 [PMID: 17176569]
26. Buxton Bridges C, Katz JM, Seto WH, Chan PK, Tsang D, Ho W, et al. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J Infect Dis. 2000;181:344-348 [PMID: 10608786] (Pubitemid 30049068)
27. Apisarnthanarak A, Erb S, Stephenson I, Katz JM, Chittaganpitch M, Sangkitporn S, et al. Seroprevalence of anti-H5 antibody among Thai health care workers after exposure to avian influenza (H5N1) in a tertiary care center. Clin Infect Dis. 2005;40:e16-8. [PMID: 15655735]
28. Liem NT, Lim W; World Health Organization International Avian Influenza Investigation Team, Vietnam. Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004. Emerg Infect Dis. 2005;11:210-215 [PMID: 15752437]
29. Bridges CB, Lim W, Hu-Primmer J, Sims L, Fukuda K, Mak KH, et al. Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998. J Infect Dis. 2002;185:1005-1010 [PMID: 11930308]
30. Wang M, Di B, Zhou DH, Zheng BJ, Jing H, Lin YP, et al. Food markets with live birds as source of avian influenza. Emerg Infect Dis. 2006;12:1773-1775 [PMID: 17283635] (Pubitemid 44679694)
31. Dinh PN, Long HT, Tien NT, Hien NT, Mai le TO, Phong le H, et al; World Health Organization/Global Outbreak Alert and Response Network Avian Influenza Investigation Team in Vietnam. Risk factors for human infection with avian influenza A H5N1, Vietnam, 2004. Emerg Infect Dis. 2006;12: 1841-1847 [PMID: 17326934]
32. Ferguson NM, Cummings DA, Fraser C, Cajka JC, Cooley PC, Burke DS. Strategies for mitigating an influenza pandemic. Nature. 2006;442:448-452 [PMID: 16642006]
33. Longini IM Jr, Nizam A, Xu S, Ungchusak K, Hanshaoworakul W, Cummings DA, et al. Containing pandemic influenza at the source. Science. 2005;309:1083-1087 [PMID: 16079251]
34. Thorson A, Petzold M, Nguyen TK, Ekdahl K. Is exposure to sick or dead poultry associated with flulike illness?: a population-based study from a rural area in Vietnam with outbreaks of highly pathogenic avian influenza. Arch Intern Med. 2006;166:119-123 [PMID: 16401820]
35. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605-2615 [PMID: 19423869]
36. Centers for Disease Control and Prevention. Seasonal influenza (flu): the disease. Accessed at www.cdc.gov/flu/about/disease.htm on 17 June 2009.
37. Hayden FG, Fritz R, Lobo MC, Alvord W, Strober W, Straus SE. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J Clin Invest. 1998;101:643-649 [PMID: 9449698] (Pubitemid 28084248)
38. Leekha S, Zitterkopf NL, Espy MJ, Smith TF, Thompson RL, Sampath-kumar P. Duration of influenza A virus shedding in hospitalized patients and implications for infection control. Infect Control Hosp Epidemiol. 2007;28:1071-1076 [PMID: 17932829] (Pubitemid 47345268)
39. FluSurge, version 2.0. Atlanta: Centers for Disease Control and Prevention; 2006.
40. Sonoguchi T, Sakoh M, Kunita N, Satsuta K, Noriki H, Fukumi H. Reinfection with influenza A (H2N2, H3N2, and H1N1) viruses in soldiers and students in Japan. J Infect Dis. 1986;153:33-40. [PMID: 3941288] (Pubitemid 16212450)
41. Monto AS, Davenport FM, Napier JA, Francis T Jr. Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren. J Infect Dis. 1970;122:16-25. [PMID: 5433709]
42. Davies JR, Grilli EA, Smith AJ. Influenza A: infection and reinfection. J Hyg (Lond). 1984;92:125-127 [PMID: 6693762]
43. Smith CB, Cox NJ, Subbarao K, Taber LH, Glezen WP. Molecular epidemiology of influenza A(H3N2) virus reinfections. J Infect Dis. 2002;185:980-985 [PMID: 11920323] (Pubitemid 34274442)
44. Centers for Disease Control and Prevention. 2008-2009 influenza season week 18 ending May 9, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly18.htm on 29 July 2009.
45. Centers for Disease Control and Prevention. 2008-2009 influenza season week 22 ending June 6, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008 -2009/weekly22.htm on 29 July 2009.
46. Centers for Disease Control and Prevention. 2008-2009 influenza season week 23 ending June 13, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly23.htm on 29 July 2009.
47. Centers for Disease Control and Prevention. 2008-2009 influenza season week 24 ending June 20, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly24.htm on 29 July 2009.
48. Centers for Disease Control and Prevention. 2008-2009 influenza season week 25 ending June 27, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008 -2009/weekly25.htm on 29 July 2009.
49. Centers for Disease Control and Prevention. 2008-2009 influenza season week 26 ending July 4, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly26.htm on 29 July 2009.
50. Centers for Disease Control and Prevention. 2008-2009 influenza season week 27 ending July 11, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008 -2009/weekly27.htm on 29 July 2009.
51. Centers for Disease Control and Prevention. 2008-2009 influenza season week 28 ending July 18, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly28.htm on 29 July 2009.
52. Centers for Disease Control and Prevention. 2008-2009 influenza season week 29 ending July 25, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008 -2009/weekly29.htm on 29 July 2009.
53. Centers for Disease Control and Prevention. 2008-2009 influenza season week 17 ending May 2, 2009. Accessed at www.cdc.gov/flu/weekly/ weeklyarchives2008-2009/weekly17.htm on 29 July 2009.
54. New York City Department of Health and Mental Hygeine. Prevent influenza. Get vaccinated! Accessed at www.nyc.gov/html/doh/html/home/home.shtml on 6 May 2009
55. Centers for Disease Control and Prevention. 2009 H1N1 flu (swine flu). Accessed at www.cdc.gov/swineflu/ on 22 June 2009.
56. Centers for Disease Control and Prevention. Questions and answers: monitoring influenza activity, including 2009 H1N1. Accessed at www.cdc.gov/h1n1flu/reportingqa.htm on 31 July 2009.
57. Ghani AC, Donnelly CA, Cox DR, Griffin JT, Fraser C, Lam TH, et al. Methods for estimating the case fatality ratio for a novel, emerging infectious disease. Am J Epidemiol. 2005;162:479-486 [PMID: 16076827] (Pubitemid 41191434)
58. World Health Organization. Global Alert and Response (GAR). Pandemic (H1N1) 2009. Accessed at www.who.int/csr/disease/swineflu/en/index.html on 22 June 2009.
59. Centers for Disease Control and Prevention. Interim CDC guidance for nonpharmaceutical community mitigation in response to human infections with swine influenza (H1N1) virus. 26 April 2009. Accessed at www.iaam.org/CVMS/Non- Pharmaceutical.pdf on 17 June 2009.
60. Davey VJ, Glass RJ, Min HJ, Beyeler WE, Glass LM. Effective, robust design of community mitigation for pandemic influenza: a systematic examination of proposed US guidance. PLoS One. 2008;3:e2606. [PMID: 18596963]
61. Cowling BJ, Chan KH, Fang VJ, Cheng CK, Fung RO, Wai W, et al. Facemasks and hand hygiene to prevent influenza transmission in households: a randomized trial. Ann Intern Med. 2009;151:437-536 [PMID: 19652172]
62. Treanor JJ, Campbell JD, Zangwill KM, Rowe T, Wolff M. Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N Engl J Med. 2006;354:1343-1351 [PMID: 16571878]
63. Leroux-Roels I, Borkowski A, Vanwolleghem T, Dramé M, Clement F, Hons E, et al. Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial. Lancet. 2007;370:580-589 [PMID: 17707753] (Pubitemid 47247854)
64. Baras B, Stittelaar KJ, Simon JH, Thoolen RJ, Mossman SP, Pistoor FH, et al. Cross-protection against lethal H5N1 challenge in ferrets with an adjuvanted pandemic influenza vaccine. PLoS One. 2008;3:e1401. [PMID: 18167560] (Pubitemid 351194015)
65. Leroux-Roels I, Bernhard R, Gérard P, Dramé M, Hanon E, Leroux-Roels G. Broad Clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine. PLoS One. 2008;3:e1665. [PMID: 18301743] (Pubitemid 351865662)
66. World Health Organization. Summary of WHO virtual consultation on the safety of adjuvanted influenza vaccines. 3 June 2009. Accessed at www.who.int/vaccine-research/documents/Report-on-consultation-on-adjuvant- safety-2.pdf on 17 June 2009.
67. Greenberg ME, Lai MH, Hartel GF, Wichems CH, Gittleson C, Bennet J, et al. Response after one dose of a monovalent influenza A (H1N1) 2009 vaccine - preliminary report. N Engl J Med. 2009. [Epub ahead of print]. [PMID: 19745216]
68. Clark TW, Pareek M, Hoschler K, Dillon H, Nicholson KG, Groth N, et al. Trial of influenza A (H1N1) 2009 monovalent mf59 - adjuvanted vaccine - preliminary report. N Engl J Med. 2009. [Epub ahead of print]. [PMID: 19745215]
69. Schnirring L. Officials lower expectations for size of first novel flu vaccine deliveries. Center for Infectious Disease Research and Policy; 14 August 2009. Accessed at www.cidrap.umn.edu/cidrap/content/influenza/swineflu/news/ aug1409vaccine.html on 14 August 2009.
70. Thorpe LE, Mostashari F, Karpati AM, Schwartz SP, Manning SE, Marx MA, et al. Mass smallpox vaccination and cardiac deaths, New York City, 1947. Emerg Infect Dis. 2004;10:917-920 [PMID: 15200831]
71. Pine AE. Vaccination ventures: explanation and outcomes of a mass smallpox vaccination clinic exercise held 17 June 2003. San Francisco: San Francisco Department of Public Health Communicable Disease Prevention Unit; 2005.
72. Centers for Disease Control and Prevention. Smallpox vaccination clinic guide. 2002. Accessed at www.bt.cdc.gov/agent/smallpox/vaccination/pdf/smallpox- vax-clinic-guide.pdf on 17 June 2009.
73. Neustadt RE, Fineberg HV. The Swine Flu Affair: Decision Making on a Slippery Disease. Washington, DC: National Academies Press Online; 1978.
74. Atkinson MP, Wein LM. Quantifying the routes of transmission for pandemic influenza. Bull Math Biol. 2008;70:820-867 [PMID: 18278533]
75. Longini IM Jr, Halloran ME, Nizam A, Yang Y. Containing pandemic influenza with antiviral agents. Am J Epidemiol. 2004;159:623-633 [PMID: 15033640] (Pubitemid 38405377)
76. U.S. Department of Health and Human Services. Pandemic influenza plan. Accessed at www.hhs.gov/pandemicflu/plan/ on 17 June 2009.
77. Centers for Disease Control and Prevention (CDC). Hospitalized patients with novel influenza A (H1N1) virus infection - California, April-May, 2009. MMWR Morb Mortal Wkly Rep. 2009;58:536-541 [PMID: 19478723]
78. Chio A, Cocito D, Leone M, Giordana MT, Mora G, Mutani R; Piemonte and Valle d'Aosta Register for Guillain-Barré Syndrome. Guillain-Barré syndrome: a prospective, population-based incidence and outcome survey. Neurology. 2003;60:1146-1150 [PMID: 12682322]
79. Mendell JR, Kissel JT, Cornblath DR. Guillain-Barré syndrome. In: Diagnosis and Management of Peripheral Nerve Disorders. New York: Oxford Univ Pr; 2001:145-172
80. Centers for Disease Control and Prevention. Seasonal influenza (flu): key facts about flu vaccination. Accessed at www.cdc.gov/flu/protect/keyfacts.htm on 25 June 2009.
81. Fryback DG, Dasbach EJ, Klein R, Klein BE, Dorn N, Peterson K, et al. The Beaver Dam Health Outcomes Study: initial catalog of health-state quality factors. Med Decis Making. 1993;13:89-102. [PMID: 8483408] (Pubitemid 23113445)
82. Turner DA, Wailoo AJ, Cooper NJ, Sutton AJ, Abrams KR, Nicholson KG. The cost-effectiveness of influenza vaccination of healthy adults 50-64 years of age. Vaccine. 2006;24:1035-1043 [PMID: 16183177]
83. U.S. Department of Health and Human Services. HHS buys additional vaccine for potential use in an influenza pandemic [press release]. 20 November 2006. Accessed at www.hhs.gov/news/press/2006pres/20061120.html on 26 July 2009.
84. County of Santa Clara. Santa Clara County Employee Earnings. San Jose Mercury News. 17 June 2007.
85. U.S. Department of Labor. Bureau of Labor Statistics. Accessed at www.bls.gov on 26 June 2009.
86. Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med. 2005; 33:1266-1271 [PMID: 15942342]
87. Talbird SE, Brogan AJ, Winiarski AP, Sander B. Cost-effectiveness of treating influenzalike illness with oseltamivir in the United States. Am J Health Syst Pharm. 2009;66:469-480 [PMID: 19233995]
88. MetLife Survey of Nursing Homes and Home Care Costs and MetLife Market Survey of Assisted Living Costs. What does long term care cost in your state? September 2006 and October 2006. Accessed at www.aarp.org/families/caregiving/ state-ltc-costs.html on 17 June 2009.
89. U.S. Census Bureau. Statistical Abstract of the United States, 2009. Accessed at www.census.gov/compendia/statab/2009edition.html on 17 June 2009.
90. Schnirring L. FDA clears CSL's vaccine-finishing facility in US. 18 August 2009. Accessed at www.cidrap.umn.edu/cidrap/content/influenza/swineflu/ news/aug1809fill-br.html on 18 August 2009.
91. Roos R. More results point to 1-dose regimen for H1N1 vaccines. 11 September 2009. Accessed at www.cidrap.umn.edu/cidrap/content/influenza/ swineflu/news/sep1109vaccine.html on 11 September 2009.
92. Yang Y, Sugimoto JD, Halloran ME, Basta NE, Chao DL, Matrajt L, et al. The transmissibility and control of pandemic influenza A (H1N1) virus. Science. 2009. [PMID: 19745114]
93. Landau E. CDC: U.S. may need 600 million swine flu vaccine doses. 1 July 2009. Accessed at www.cnn.com/2009/HEALTH/07/01/swine.flu.h1n1.vaccine/index. html on 29 July 2008.
94. World Health Organization. Safety of pandemic vaccines. 6 August 2009. Accessed at www.who.int/csr/disease/swineflu/notes/h1n1-safety-vaccines- 20090805/en/index.html on 6 August 2009.
95. Glass RJ, Glass LM, Beyeler WE, Min HJ. Targeted social distancing design for pandemic influenza. Emerg Infect Dis. 2006;12:1671-1681 [PMID: 17283616]
96. Larson RC. Simple models of influenza progression within a heterogeneous population. Operations Research. 2007;55:399-412.
97. Arino J, Brauer F, van den Driessche P, Watmough J, Wu J. Simple models for containment of a pandemic. J R Soc Interface. 2006;3:453-457 [PMID: 16849273]
98. McKibbin WJ, Sidorenko A. Global macroeconomic consequences of pandemic influenza. 1 February 2006. Accessed at www.brookings.edu/papers/2006/ 02development-mckibbin.aspx on 17 June 2009.
99. U.S. Congress. Supplemental Appropriations Act. Accessed at www.govtrack.us/congress/bill.xpd?bill=h111-2346 on 28 July 2009.