HPLC enantioseparation of α,α-diphenyl-2-pyrrolidinemethanol and methylphenidate using a chiral fluorescent derivatization reagent and its application to the analysis of rat plasma

Journal of Separation Science

Volumn 33, Issue 20, 2010, Pages 3137-3143

  Inagaki, Shinsuke ^a   Taniguchi, Sayuri ^a   Hirashima, Haruo ^a   Higashi, Tatsuya ^a   Min, Jun Zhe ^a   Kikura Hanajiri, Ruri ^b   Goda, Yukihiro ^b   Toyo'oka, Toshimasa ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

, Diphenyl 2 pyrrolidinemethanol; Enantioseparation; Fluorescence detection; HPLC; Methylphenidate

Indexed keywords

DERIVATIZATION REAGENT; DETECTION LIMITS; ENANTIOSEPARATIONS; FLUORESCENCE DETECTION; HPLC; METHYLPHENIDATE; RAT PLASMA; RELIABLE DETECTION; RESOLUTION FACTORS; REVERSED-PHASE SYSTEMS; RITALIN;

PLASMA (HUMAN);

FLUORESCENCE;

4 (N,N DIMETHYLAMINOSULFONYL) 7 (3 ISOTHIOCYANATOPYRROLIDIN 1 YL) 2,1,3 BENZOXADIAZOLE; ALPHA, ALPHA DIPHENYL 2 PYRROLIDINEMETHANOL; METHYLPHENIDATE; REAGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORESCENT DYES; MALE; METHYLPHENIDATE; MOLECULAR STRUCTURE; PYRROLIDINES; RATS; RATS, WISTAR; STEREOISOMERISM;

RATTUS;

EID: 78349288509     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000479     Document Type: Article

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