Impaired free water excretion in child C cirrhosis and ascites: Relations to distal tubular function and the vasopressin system

Liver International

Volumn 30, Issue 9, 2010, Pages 1364-1370

  Krag, Aleksander ^a   Møller, Søren ^a   Pedersen, Erling B ^b   Henriksen, Jens H ^a   Holstein Rathlou, Niels Henrik ^c   Bendtsen, Flemming ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b HOLSTEBRO HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aquaporin 2; Ascites; Vasopressin

Indexed keywords

AQUAPORIN 2; LITHIUM CARBONATE; VASOPRESSIN;

ADULT; AGED; ARTICLE; ASCITES; CONTROLLED STUDY; DIURESIS; FEMALE; FLUID INTAKE; FREE WATER CLEARANCE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; URINE FLOW RATE; VASOPRESSIN BLOOD LEVEL; WATER LOADING; WATER RETENTION;

ASCITES; BODY WATER; DIURESIS; FEMALE; HUMANS; KIDNEY TUBULES, DISTAL; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; VASOPRESSINS; WATER-ELECTROLYTE IMBALANCE;

EID: 78349268311     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02319.x     Document Type: Article

References (45)

1. D'Amico G, Morabito A, Pagliaro L, Marubini E. Survival and prognostic indicators in compensated and decompensated cirrhosis. Dig Dis Sci 1986; 31: 468-75.
2. Gines P, Quintero E, Arroyo V, et al. Compensated cirrhosis: natural history and prognostic factors. Hepatology 1987; 7: 122-8.
3. Salerno F, Camma C, Enea M, et al. Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data. Gastroenterology 2007; 133: 825-34.
4. Schrier RW, Arroyo V, Bernardi M, et al. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 8: 1151-7.
5. Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology 2006; 43: S121-31.
6. Gines P, Cardenas A, Arroyo V, Rodes J. Management of Cirrhosis and Ascites. N Engl J Med 2004; 350: 1646-54.
7. Schrier RW. Decreased effective blood volume in edematous disorders: what does this mean? J Am Soc Nephrol 2007; 18: 2028-31.
8. Arroyo V, Colmenero J. Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management. J Hepatol 2003; 38: S69-89.
9. Fenton RA, Knepper MA. Mouse models and the urinary concentrating mechanism in the new millennium. Physiol Rev 2007; 87: 1083-112.
10. Treschan TA, Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology 2006; 105: 599-612.
11. Nielsen S, Frokiaer J, Marples D, et al. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 2002; 82: 205-44.
12. Gines P, Wong F, Watson H, et al. Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial. Hepatology 2008; 48: 204-13.
13. Wong F, Bernardi M, Horsmans Y, et al. Effects of satavaptan, an oral vasopressin V2 receptor antagonist, on management of ascites and morbidity in liver cirrhosis in a long-term, placebo-controlled study. J Hepatol 2009; 50: 42.
14. Arroyo V, Gines P, Gerbes AL, et al. Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club. Hepatology 1996; 23: 164-76.
15. Krag A, Møller S, Henriksen JH, et al. Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome. Hepatology 2007; 46: 1863-71.
16. Flynn FV. Assessment of renal function: selected developments. Clin Biochem 1990; 23: 49-54.
17. Sambataro M, Thomaseth K, Pacini G, et al. Plasma clearance rate of 51Cr-EDTA provides a precise and convenient technique for measurement of glomerular filtration rate in diabetic humans. J Am Soc Nephrol 1996; 7: 118-27.
18. Gaspari F, Perico N, Remuzzi G. Measurement of glomerular filtration rate. Kidney Int 1997; 63: S151-4.
19. Hutchings M, Hesse B, Gronvall J, Olsen NV. Renal 131I-hippuran extraction in man: effects of dopamine. Br J Clin Pharmacol 2002; 54: 675-7.
20. Schlegel JU, Smith BG, O'dell RM. Estimation of effective renal plasma flow using I-131-labeled hippuran. J Appl Physiol 1962; 17: 80-2.
21. Pedersen RS, Bentzen H, Bech JN, Pedersen EB. Effect of water deprivation and hypertonic saline infusion on urinary AQP2 excretion in healthy humans. Am J Physiol Renal Physiol 2001; 280: F860-7.
22. Pedersen EB, Danielsen H, Spencer ES. Effect of indapamide on renal plasma flow, glomerular filtration rate and arginine vasopressin in plasma in essential hypertension. Eur J Clin Pharmacol 1984; 26: 543-7.
23. Angeli P, De BE, Dalla PM, et al. Effects of amiloride on renal lithium handling in nonazotemic ascitic cirrhotic patients with avid sodium retention. Hepatology 1992; 15: 651-4.
24. Koomans HA, Boer WH, Dorhout Mees EJ. Evaluation of lithium clearance as a marker of proximal tubule sodium handling. Kidney Int 1989; 36: 2-12.
25. Thomsen K. Lithium clearance: a new method for determining proximal and distal tubular reabsorption of sodium and water. Nephron 1984; 37: 217-23.
26. Bichet DG, Van PV, Schrier RW. Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis. N Engl J Med 1982; 307: 1552-7.
27. Bichet D, Szatalowicz V, Chaimovitz C, Schrier RW. Role of vasopressin in abnormal water excretion in cirrhotic patients. Ann Intern Med 1982; 96: 413-7.
28. Hadrup N, Petersen JS, Windfeld S, et al. Differential down-regulation of aquaporin-2 in rat kidney zones by peripheral nociceptin/orphanin FQ receptor agonism and vasopressin type-2 receptor antagonism. J Pharmacol Exp Ther 2007; 323: 516-24.
29. Hadrup N, Petersen JS, Praetorius J, et al. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Am J Physiol Renal Physiol 2004; 287: F160-8.
30. Brond L, Hadrup N, Salling N, et al. Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis. Am J Physiol Renal Physiol 2004; 287: F806-15.
31. De SS, Nielsen J, Olesen ET, et al. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. Am J Physiol Renal Physiol 2007; 293: F87-99.
32. Kwon TH, Nielsen J, Knepper MA, et al. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Am J Physiol Renal Physiol 2005; 288: F673-84.
33. Wong NL, Tsui JK. Angiotensin II upregulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. Metabolism 2003; 52: 290-5.
34. Lee YJ, Song IK, Jang KJ, et al. Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor. Am J Physiol Renal Physiol 2007; 292: F340-50.
35. Murase T, Ecelbarger CA, Baker EA, et al. Kidney aquaporin-2 expression during escape from antidiuresis is not related to plasma or tissue osmolality. J Am Soc Nephrol 1999; 10: 2067-75.
36. Jonassen TE, Nielsen S, Christensen S, Petersen JS. Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis. Am J Physiol 1998; 275: F216-25.
37. Jonassen TE, Christensen S, Kwon TH, et al. Renal water handling in rats with decompensated liver cirrhosis. Am J Physiol Renal Physiol 2000; 279: F1101-9.
38. Bouley R, Hawthorn G, Russo LM, et al. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell 2006; 98: 215-32.
39. Oakley RH, Laporte SA, Holt JA, et al. Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem 1999; 274: 32248-57.
40. Holmes CL, Landry DW, Granton JT. Science review: vasopressin and the cardiovascular system part 1-receptor physiology. Crit Care 2003; 7: 427-34.
41. Berstein SH, Weston RE, Ross G, et al. Studies on intravenous water diuresis and nicotine and pitressin antiduresis in normal subjects and patients with liver disease. J Clin Invest 1953; 32: 422-7.
42. Nelson WP, Welt LG. The effects of pitressin on the metabolism and excretion of water and electrolytes in normal subjects and patients with cirrhosis and ascites. J Clin Invest 1952; 31: 392-400.
43. Esteva-Font C, Baccaro ME, Fernandez-Llama P, et al. Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: relationship with ascites and hepatorenal syndrome. Hepatology 2006; 44: 1555-63.
44. Jonassen TE, Promeneur D, Christensen S, et al. Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade. Am J Physiol Renal Physiol 2000; 278: F246-56.
45. Marples D, Christensen BM, Frokiaer J, et al. Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats. Am J Physiol 1998; 275: F400-9.