Association between interleukin-4R and TGF-β1 gene polymorphisms and the risk of colorectal cancer in a Korean population

Colorectal Disease

Volumn 12, Issue 12, 2010, Pages 1208-1212

  Lee, Y S ^a   Choi, H B ^a   Lee, I K ^a   Kim, T G ^a   Oh, S T ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Colorectal cancer; Interleukin 4R; Polymorphisms; Transforming growth factor 1

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECTUM CANCER; RISK;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-2; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, INTERLEUKIN-4; TRANSFORMING GROWTH FACTOR BETA1;

EID: 78349267167     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2009.02080.x     Document Type: Article

References (26)

1. Hill MJ, Morson BC, Bussey HJ. Etiology of adenoma-carcinoma sequence in large bowel. Lancet 1977; 1: 245-7.
2. Fijneman RJ. Genetic predisposition to sporadic cancer: how to handle major effects of minor genes? Cell Oncol 2005; 27: 281-92.
3. Berghella AM, Pellegrini P, Del Beato T, Marini M, Tomei E, Adorno D, Casciani CU. The significance of an increase in soluble interleukin-2 receptor in colorectal cancer and its biological regulating role in the physiological switching of the immune response cytokine network from TH1 to TH2 and back. Cancer Immunol Immunother 1998; 45: 241-9.
4. Shibata M, Nezu T, Takekawa M, Takizawa H, Ando K, Miyake H, Amano S, Kurosu Y. Serum levels of interleukin-10 and interleukin-12 in patients with colorectal cancer. Ann N Y Acad Sci 1996; 795: 410-2.
5. Tsushima H, Kawata S, Tamura S et al. High levels of transforming growth factor 1 in patients with colorectal cancer: association with disease progression. Gastroenterology 1996; 110: 375-82.
6. Atreya R, Neurath MF. Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol 2005; 28: 187-96.
7. Csiszar A, Szentes T, Haraszti B, Balazs A, Petranyi GG, Pocsik E. The pattern of cytokine gene expression in human colorectal carcinoma. Pathol Oncol Res 2004; 2: 109-16.
8. Morse HR, Olomolaiye OO, Wood NA, Keen LJ, Bidwell JL. Induced heteroduplex genotyping of TNF-alpha, IL-1beta, IL-6 and IL-10 polymorphisms associated with transcriptional regulation. Cytokine 1999; 11: 789-95.
9. Pyo CH, Hur SS, Kim YK, Choi HB, Hong YS, Kim DW, Kim CC, Kim HK, Kim TG. Polymorphisms of IL-1B, IL-1RN, IL-2, IL-4, IL-6, IL-10, and IFN-gamma genes in the Korean population. Hum Immunol 2003; 64: 979-89.
10. Laundy GJ, Bidwell JL. Human cytokine gene nucleotide sequence alignments: interleukin 4 receptor alpha chain (IL4RA), IL5RA, IL8, IL8RB and IL13. Eur J Immunogenet 2003; 30: 13-87.
11. Pitts SA, Olomolaiye OO, Elson CJ, Westacott CI, Bidwell JL. An MspA1 I polymorphism in exon 1 of the human TNF receptor type I (p55) gene. Eur J Immunogenet 1998; 25: 271-2.
12. Kaklamanis L, Gatter KG, Mortensen N, Harris AL. Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer. Br J Cancer 1992; 66: 712-6.
13. Li BH, Yang XZ, Li PD, Yuan Q, Liu XH, Yuan J, Zhang WJ. IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. Biochem Biophys Res Commun 2008; 369: 554-60.
14. Todaro M, Alea MP, Scopelliti A, Medema JP, Stassi G. IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle 2008; 7: 309-13.
15. Puthothu B, Krueger M, Forster J, Heinzmann A. Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J Infect Dis 2006; 193: 438-41.
16. Suppiah V, Goris A, Alloza I Heqqarty S et al. Polymorphisms in the interleukin-4 and IL-4 receptor genes and multiple sclerosis: a study in Spanish-Basque, Northern Irish and Belgian populations. Int J Immnogenet 2005; 32: 383-8.
17. Wu MC, Huang CM, Tsai JJ, Chen HY, Tsai FJ. Polymorphisms of the interleukin-4 gene in Chinese patients with systemic lupus erythematosus in Taiwan. Lupus 2003; 12: 21-5.
18. Landi S, Bottari F, Gemignani F, Gioia-Patricola L, Guino E, Osorio A, Oca J, Cappella G, Canzia F, Moreno V. Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk. Eur J Cancer 2007; 43: 762-8.
19. Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev 2006; 15: 1126-31.
20. Xu Y, Pasche B. TGF-β signaling alteration and susceptibility to colorectal cancer. Hum Mol Genet 2007; 16: R14-20.
21. Kretzschmar M. Transforming growth factor-beta and breast cancer: transforming growth factor-β/SMAD signaling defects and cancer. Breast Cancer Res 2000; 2: 107-15.
22. Massague J, Blain SW, Lo RS. TGFß signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
23. Kulkarni AB, Hug CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn AB, Ward KM, Karisson S. Transforming growth factor ß 1 null mutation in mice excessive inflammatory response and early death. Proc Matl Acad Sci USA 1993; 90: 770-4.
24. Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev 2005; 14: 1613-8.
25. Sparks R, Bigler J, Sibert JG, Potter JD, Yasui Y, Ulrich CM. TGF β1 polymorphisms (L10P) and risk colorectal adenomatous and hyperplastic polyps. Int J Epidemiol 2004; 33: 955-61.
26. Chung SJ, Kim JS, Jung HC, Song IS. Transforming growth factor-b1-509T reduces risk of colorectal cancer, but not adenoma in Koreans. Cancer Sci 2007; 98: 401-4.