Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients

Clinical Cancer Research

Volumn 16, Issue 22, 2010, Pages 5522-5528

  Pataer, Abujiang ^a   Raso, Maria Gabriela ^a   Correa, Arlene M ^a   Behrens, Carmen ^a   Tsuta, Koji ^a   Solis, Luisa ^a   Fang, Bingliang ^a   Roth, Jack A ^a   Wistuba, Ignacio I ^a   Swisher, Stephen G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE R;

ARTICLE; BRONCHUS MUCOSA; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER SURVIVAL; CELL DEATH; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE COURSE; EVALUATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; SCORING SYSTEM; TISSUE MICROARRAY; VALIDATION STUDY;

BRONCHI; CARCINOMA, NON-SMALL-CELL LUNG; EIF-2 KINASE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; PROGNOSIS; TISSUE ARRAY ANALYSIS;

EID: 78349252338     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0753     Document Type: Article

References (30)

1. Barber GN. Host defense, viruses and apoptosis. Cell Death Differ 2001;8:113-26.
2. Williams BRG. Signal integration via PKR. Sci STKE 2001;89:RE2.
3. Katze MG. The war against the interferon-induced dsRNA-activated protein kinase: can viruses win? J Interferon Res 1992;12:241-8.
4. Jagus R, Joshi B, Barber GN. PKR, apoptosis and cancer. Int J Biochem Cell Biol 1999;31:123-38.
5. Gil J, Esteban M. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis 2000;5: 107-14.
6. Terada T, Maeta H, Endo K, Ohta T. Protein expression of double-stranded RNA activated protein kinase in thyroid carcinomas: correlations with histologic types, pathologic parameters, and Ki-67 labeling. Hum Pathol 2000;31:817-21.
7. Kim SH, Gunnery S, Choe JK, Mathews MB. Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR. Oncogene 2002;21:8741-8.
8. Roh MS, Kwak JY, Kim SJ, et al. Expression of double-stranded RNA-activated protein kinase in small-size peripheral adenocarcinoma of the lung. Pathol Int 2005;55:688-93.
9. Haines GK III, Becker S, Ghadge G, Kies M, Pelzer H, Radosevich JA. Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region. Arch Otolaryngol Head Neck Surg 1993;119:1142-7.
10. Singh C, Haines GK, Talamonti MS, Radosevich JA. Expression of p68 in human colon cancer. Tumour Biol 1995;16:281-9.
11. Haines GK, Ghadge G, Thimmappaya B, Radosevich JA. Expression of the protein kinase p-68 recognized by the monoclonal antibody TJ4C4 in human lung neoplasms. Virchows Arch B Cell Pathol Incl Mol Pathol 1992;62:151-8.
12. Haines GK, Ghadge GD, Becker S, et al. Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol 1993;63:289-95.
13. Haines GK, Cajulis R, Hayden R, Duda R, Talamonti M, Radosevich JA. Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues. Tumour Biol 1996;17:5-12.
14. Haines GK, Panos RJ, Bak PM, et al. Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma. Tumor Biol 1998;19:52-9.
15. Shimada A, Shiota G, Miyata H, et al. Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. Cancer Res 1998;58:4434-8.
16. Terada T, Ueyama J, Ukita Y, Ohta T. Protein expression of double-stranded RNA-activated protein kinase (PKR) in intrahepatic bile ducts in normal adult livers, fetal livers, primary biliary cirrhosis, hepatolithiasis and intrahepatic cholangiocarcinoma. Liver 2000;20: 450-7.
17. Beretta L, Gabbay M, Berger R, Hanash SM, Sonenberg N. Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias. Oncogene 1996;12:1593-6.
18. Hii SI, Hardy L, Crough T, et al. Loss of PKR activity in chronic lymphocytic leukemia. Int J Cancer 2004;109:329-35.
19. Murad JM, Tone LG, de Souza LR, De Lucca FL. A point mutation in the RNA-binding domain I results in decrease of PKR activation in acute lymphoblastic leukemia. Blood Cells Mol Dis 2005;34:1-5.
20. Pataer A, Vorburger SA, Barber GN, et al. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 2002;62:2239-43.
21. Vorburger SA, Pataer A, Yoshida K, et al. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene 2002;21:6278-88.
22. Holzen UV, Bocangel D, Pataer A, et al. Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-α gene therapy in esophageal cancer. Surgery 2005;138:261-8.
23. Pataer A, Vorburger SA, Chada S, et al. Melanoma differentiation- associated gene-7 protein physically associates with the doublestranded RNA-activated protein kinase PKR. Mol Ther 2005;11: 717-23.
24. von Holzen U, Pataer A, Raju U, et al. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor κB and Akt activation. Clin Cancer Res 2007;13:6032-9.
25. Hu W, Hofstetter W, Guo W, et al. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of doublestranded RNA-dependent protein kinase. Cancer Gene Ther 2008; 15:616-24.
26. Prudkin L, Behrens C, Liu DD, et al. Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. Clin Cancer Res 2008;14:41-7.
27. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, International Agency for Research on Cancer (IARC). Pathology and genetics: tumours of the lung, pleura and heart, editors. Lyon: IARC; 2004.
28. Der SD, Yang YL, Weissmann C, Williams BR. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A 1997;94: 3279-83.
29. Balachandran S, Kim CN, Yeh WC, Mak TW, Bhalla K, Barber GN. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J 1998;17: 6888-902.
30. Ishikawa S, Nakagawa T, Miyahara R, et al. Expression of MDA-7/IL-24 and its clinical significance in resected non-small cell lung cancer. Clin Cancer Res 2005;11:1198-202.