Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda

Planta Medica

Volumn 76, Issue 16, 2010, Pages 1870-1873

  Sebisubi, Fred Musoke ^a,c,d   Odyek, Olwa ^b   Anokbonggo, William Wilberforce ^b   Ogwal Okeng, Jasper ^b   Carcache Blanco, Esperanza J ^c,e   Ma, Cuiying ^c,f   Orjala, Jimmy ^c   Tan, Ghee T ^a,c  

^a UNIVERSITY OF HAWAII AT HILO   (United States)

^b MAKERERE UNIVERSITY   (Uganda)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d MINISTRY OF HEALTH   (Uganda)

^e OHIO STATE UNIVERSITY   (United States)

^f UNITED STATES PHARMACOPEIA   (United States)

Author keywords

Aspilia pruliseta; Asteraceae; diterpenes; ent 15 senecioyloxy16,17epoxykauran18oic acid; malaria; Plasmodium falciparum

Indexed keywords

15 (2Z) [(2 METHYL 1 OXO 2 BUTENYL)OXY] 4ALPHA, 15BETA KAUR 16 EN 18 OIC ACID; 15 [(2 METHYL 1 OXO 2 BUTENYL)OXY] 4ALPHA,15BETA(E) KAUR 16 EN 18 OIC ACID; 16,17 EPOXY 15 [(2 METHYL 1 OXO 2 BUTENYL)OXY] 4ALPHA,15BETA(Z) KAURAN 18 OIC ACID; 16,17 EPOXY 15 [(2 METHYL 1 OXO 2 BUTENYL)OXY]4ALPHA,15BETA(E) KAURAN 18 OIC ACID; ASPILIA PRULISETA EXTRACT; CHLOROQUINE; DITERPENE; ENT 15BETA SENECIOYLOXY 16,17 EPOXY KAURAN 18 OIC ACID; ENT 15BETA SENECIOYLOXY KAUR 16 EN 19 OIC ACID; ENT 16 KAUREN 19 OL; KAURENIC ACID; PLANT EXTRACT; UNCLASSIFIED DRUG; VINBLASTINE SULFATE;

ANTIMALARIAL ACTIVITY; ARTICLE; ASPILIA PRULISETA; ASTERACEAE; CLONE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; PLASMODIUM FALCIPARUM; TRADITIONAL MEDICINE; UGANDA;

ANTIMALARIALS; ASTERACEAE; CHLOROQUINE; DITERPENES; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MEDICINE, AFRICAN TRADITIONAL; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; UGANDA;

ASPILIA; ASTERACEAE; PLASMODIUM FALCIPARUM;

EID: 78349250609     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250028     Document Type: Article

References (25)

1. Kokwaro J O. Medicinal plants of East Africa. Kampala, Nairobi, Dar es Salaam East African Literature Bureau 1976
2. Adjanohoun J E., Ahyi M R. A., Aké Assi L, Alia A M., Amai C A., Gbile Z O., Johnson C L. A., Kakooko Z O., Lutakome H K., Morakinyo O, Mubiru N K., Ogwal-Okeng J W., Sofowora E A. Traditional medicine and pharmacopoeia contribution to ethnobotanical and floristic studies in Uganda. Scientific, Technical and Research Commission of the Organization of the African Unity (OAU/STRC) 1993
3. Lind E M., Tallantire A C. Some common flowering plants of Uganda. Nairobi Oxford University Press 1971 171
4. Watt J M., Breyer-Branndwijk M G. The medicinal and poisonous plants of southern and eastern Africa. Edinburgh E. & S. Livingston Ltd. 1962
5. Ayensu E S. Medicinal plants of West Africa. Michigan Reference Public Press 1979
6. Huffman M A., Seifu M. Observations on the illness and consumption of a possibly medicinal plant Vernonia amygdalina (DEL.), by a wild chimpanzee in the Mahale Mountains National Park, Tanzania. Primates 1989 30 51-63
7. Wrangham R, Nishida T. Aspilia spp. leaves: a puzzle in the feeding behavior of wild chimpanzees. Primates 1983 24 276-282
8. Cos P, Hermans N, Van Poel B, De Bruyne T, Apers S, Sindambiwe J B., Vanden Berghe D, Pieters L, Vlietinck A J. Complement modulating activity of Rwandan medicinal plants. Phytomedicine 2002 9 56-61
9. Cos P, Hermans N, De Bruyne T, Apers S, Sindambiwe J B., Witvrouw M, De Clercq E, Vanden Berghe D, Pieters L, Vlietinck A J. Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1). Phytomedicine 2002 9 62-68
10. Lwande W C., Okecj M, Macfoy F, Delle M, Marino Bettolo G B. Research on African medicinal plants. Part VIII. Kaurenoic acids from Aspilia pluriseta. Fitoterapia 1985 56 126-128
11. Rodriguez E, Aregullin M, Nishida T, Uehara S, Wrangham R, Abramowski Z, Finlayson A, Towers G H. N. Thiarubrine A, a bioactive constituent of Aspilia (Asteraceae) consumed by the wild chimpanzee. Experientia 1985 41 419-420
12. Bohlmann F, Jakupovic J, Ates N, Schuster A, Pickardt J, King R M., Robinson H. Steiractinolides, a new group of sesquiterpene lactones. Liebigs Ann Chem 1983 6 962-973
13. Bohlmann F, Zdero C. Eine neue diterpensäure aus Perymenium ecuadoricum. Phytochemistry 1977 16 786-787
14. Bohlmann F, Ziesche J, King R M., Robinson H. Neue Melampolide aus Smallanthus fruticocus. Phytochemistry 1980 19 973-974
15. Bohlmann F, Zdero C, King R M., Robinson H. Eudesmanolides and kaurene derivatives from Wedelia hookeriana. Phytochemistry 1982 21 2329-2333
16. Bohmann F, Ziesche J, King R M., Robinson H. Eudesmanolides and diterpenes from Wedelia trilobata and an ent -kaurenic acid derivative from Aspilia parvifolia. Phytochemistry 1981 20 751-756
17. Gao F, Wang H, Marbry J T. Diterpenoids and a sesquiterpene from Viguiera ladibracte. Phytochemistry 1987 26 779-781
18. Herz W, Sosa E V. 10 -methyl-eudesman-8 H,12-olides and other constituents from Wedelia pinetorium. Phytochemistry 1986 25 1481-1483
19. Trager W, Jensen J B. Human malaria parasites in continuous culture. Science 1976 193 673-675
20. Desjardins R E., Canfield C J., Haynes J D., Chulay J D. Quantitative assessment of antimalarial activity in vitro by a semi-automated microdilution technique. Antimicrob Agents Chemother 1979 16 710-718
21. Ma C Y., Zhang H J., Tan G T., Hung N V., Cuong N M., Soejarto D D., Fong H H. S. Antimalarial compounds from Grewia bilamellata. J Nat Prod 2006 69 346-350
22. Zhang H J., Tamez P A., Aydogmus Z, Tan G T., Saikawa Y, Hashimoto K, Nakata M, Hung N V., Xuan L T., Cuong N M., Soejarto D D., Pezzuto J M., Fong H H. S. Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. Planta Med 2002 68 1088-1091 (Pubitemid 36140313)
23. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren J T., Boskesch H, Kenney S, Boyd M R. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990 82 1107-1112
24. Rubinstein L V., Shoemaker R H., Paull K D., Simon R M., Tosini S, Skehan P, Scudiero D A., Monks A, Boyd M R. Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 1990 82 1113-1118
25. Zhang H J., Tamez P A., Hoang V D., Tan G T., Hung N V., Xuan L T., Huong L M., Cuong N M., Thao D T., Soejarto D D., Fong H H. S., Pezzuto J M. Antimalarial compounds from Rhaphidophora decursiva. J Nat Prod 2001 64 772-777